Rebecca Lester
@rlester.bsky.social
Infectious Diseases specialist doctor (Royal Free London) and academic (UCL). Research focuses on preventing antimicrobial resistance and some fun stuff like phages 🦠
Reposted by Rebecca Lester
Great paper out by Ben Chan, Jon Koff and co at Yale highlighting compassionate use of phage therapy in nine patients with CF with multi-drug resistant strains of Pseudomonas aeruginosa
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis - Nature Medicine
A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacteria...
www.nature.com
May 1, 2025 at 2:29 PM
Great paper out by Ben Chan, Jon Koff and co at Yale highlighting compassionate use of phage therapy in nine patients with CF with multi-drug resistant strains of Pseudomonas aeruginosa
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rebecca Lester
Beginning to scratch the surface of the microbiome resistome, and what it means for risk of infections and #AMR
#IDSky #ClinMicro
CC @rlester.bsky.social
academic.oup.com/jid/advance-...
#IDSky #ClinMicro
CC @rlester.bsky.social
academic.oup.com/jid/advance-...
The gut microbiome and its resistome as predictors of clinical infections and phenotypic antibiotic resistance in hematopoietic stem cell transplant recipients
metagenomics to enhance the understanding of infectious sources and to
identify patients at risk of clinical infection with antibiotic-resistant bacterial strains.
academic.oup.com
June 27, 2025 at 10:18 PM
Beginning to scratch the surface of the microbiome resistome, and what it means for risk of infections and #AMR
#IDSky #ClinMicro
CC @rlester.bsky.social
academic.oup.com/jid/advance-...
#IDSky #ClinMicro
CC @rlester.bsky.social
academic.oup.com/jid/advance-...
Reposted by Rebecca Lester
#NatMicroPicks
Tracking the gut microbiome evolution 🦠
A big data analysis of gut microbiome of kids from infancy to 8 years of age.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
Tracking the gut microbiome evolution 🦠
A big data analysis of gut microbiome of kids from infancy to 8 years of age.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
Gut microbiome evolution from infancy to 8 years of age - Nature Medicine
In a unique cohort of twins followed from birth to 8 years of age, shotgun sequencing of stool samples reveals that the transmission, persistence and evolutionary adaptation of bacterial strains are s...
www.nature.com
June 26, 2025 at 3:32 PM
#NatMicroPicks
Tracking the gut microbiome evolution 🦠
A big data analysis of gut microbiome of kids from infancy to 8 years of age.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
Tracking the gut microbiome evolution 🦠
A big data analysis of gut microbiome of kids from infancy to 8 years of age.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
Reposted by Rebecca Lester
Just made a custom feed that pulls in a wide array of hashtags being used at ESCMID Global 2025
May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025
Feel free to pin it to your timelines. Hope it's helpful #IDSky
bsky.app/profile/did:...
May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025
Feel free to pin it to your timelines. Hope it's helpful #IDSky
bsky.app/profile/did:...
April 12, 2025 at 1:51 PM
Just made a custom feed that pulls in a wide array of hashtags being used at ESCMID Global 2025
May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025
Feel free to pin it to your timelines. Hope it's helpful #IDSky
bsky.app/profile/did:...
May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025
Feel free to pin it to your timelines. Hope it's helpful #IDSky
bsky.app/profile/did:...
Absolutely. Epi and surveillance the first step towards improving therapy @gpollara.bsky.social
The lack of sentinel surveillance for resistance in uncomplicated UTI has come up as a question several times now in the sessions I've attended today at #ESCMIDGlobal
If we don't have a true handle on the epi & resistance, how can we really think about doing better? 🤔
#UTISky
#IDSky
If we don't have a true handle on the epi & resistance, how can we really think about doing better? 🤔
#UTISky
#IDSky
April 12, 2025 at 12:22 PM
Absolutely. Epi and surveillance the first step towards improving therapy @gpollara.bsky.social
We've been looking at using antibiotic spectrum scores to guide our antimicrobial stewardship practice.
Come and listen to Ben Moshy present our findings so far, work led by @rlester.bsky.social & I.
#ESCMIDGlobal #ESCMID2025 #IDSky #ClinMicro #AMR #AMS
Come and listen to Ben Moshy present our findings so far, work led by @rlester.bsky.social & I.
#ESCMIDGlobal #ESCMID2025 #IDSky #ClinMicro #AMR #AMS
April 12, 2025 at 8:28 AM
Reposted by Rebecca Lester
Yeah personally we should drop the word de-escalation. What are we going up or down on anwyay?
The issue is breadth of antimicrobial coverage, measured bluntly by the number of species that you catch within your antibacterial net!
@rlester.bsky.social & I working on this area. Watch this space...
The issue is breadth of antimicrobial coverage, measured bluntly by the number of species that you catch within your antibacterial net!
@rlester.bsky.social & I working on this area. Watch this space...
December 16, 2024 at 10:55 PM
Yeah personally we should drop the word de-escalation. What are we going up or down on anwyay?
The issue is breadth of antimicrobial coverage, measured bluntly by the number of species that you catch within your antibacterial net!
@rlester.bsky.social & I working on this area. Watch this space...
The issue is breadth of antimicrobial coverage, measured bluntly by the number of species that you catch within your antibacterial net!
@rlester.bsky.social & I working on this area. Watch this space...
Reposted by Rebecca Lester
I’ll handle this, @gpollara.bsky.social.
Dr Lester, in my experience it goes Start Smart; Focus; escalated overnight by F1 for a temp of 37.3; de-escalate again; back on IV because AMT 9/10; on orals after 10d IV to finish off; but it’s high dose Cipro obviously and the patient just died of C.diff
Dr Lester, in my experience it goes Start Smart; Focus; escalated overnight by F1 for a temp of 37.3; de-escalate again; back on IV because AMT 9/10; on orals after 10d IV to finish off; but it’s high dose Cipro obviously and the patient just died of C.diff
December 7, 2024 at 11:24 AM
I’ll handle this, @gpollara.bsky.social.
Dr Lester, in my experience it goes Start Smart; Focus; escalated overnight by F1 for a temp of 37.3; de-escalate again; back on IV because AMT 9/10; on orals after 10d IV to finish off; but it’s high dose Cipro obviously and the patient just died of C.diff
Dr Lester, in my experience it goes Start Smart; Focus; escalated overnight by F1 for a temp of 37.3; de-escalate again; back on IV because AMT 9/10; on orals after 10d IV to finish off; but it’s high dose Cipro obviously and the patient just died of C.diff
Brilliant to have outcomes @gpollara.bsky.social
Start smart, then focus, then what?
#AMS #AMR #IDSky #ClinMicro
Start smart, then focus, then what?
#AMS #AMR #IDSky #ClinMicro
Start smart, then focus
The UK slogan as applicable now as when first coined, in the world of antimicrobial stewardship
#AMS #AMR #IDSky #ClinMicro @rlester.bsky.social
academic.oup.com/cid/advance-...
The UK slogan as applicable now as when first coined, in the world of antimicrobial stewardship
#AMS #AMR #IDSky #ClinMicro @rlester.bsky.social
academic.oup.com/cid/advance-...
Epidemiology and Outcomes of Antibiotic De-escalation in Patients with Suspected Sepsis in US Hospitals
Across 236 US hospitals, de-escalation of anti-MRSA and anti-pseudomonal antibiotics in suspected sepsis was infrequent and variable across hospitals. De-e
academic.oup.com
December 7, 2024 at 10:00 AM
Brilliant to have outcomes @gpollara.bsky.social
Start smart, then focus, then what?
#AMS #AMR #IDSky #ClinMicro
Start smart, then focus, then what?
#AMS #AMR #IDSky #ClinMicro
Excellent from BSAC
Noted the social links at the bottom of BSAC (@bsacandjac.bsky.social) newsletter
A new 🦋 and no ✖️ #IDSky
A new 🦋 and no ✖️ #IDSky
December 5, 2024 at 7:19 AM
Excellent from BSAC
This is very cool phage work. Studies of phage-antibiotic co-administration crucial for understanding impact on AMR.
Time to overcome barriers to phage administration so more work like this can be done 💪 #IDSky
www.sciencedirect.com/science/arti...
Time to overcome barriers to phage administration so more work like this can be done 💪 #IDSky
www.sciencedirect.com/science/arti...
Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised...
The rate of antibiotic resistance continues to grow, outpacing small-molecule-drug development efforts. Novel therapies are needed to combat this grow…
www.sciencedirect.com
November 28, 2024 at 1:23 PM
This is very cool phage work. Studies of phage-antibiotic co-administration crucial for understanding impact on AMR.
Time to overcome barriers to phage administration so more work like this can be done 💪 #IDSky
www.sciencedirect.com/science/arti...
Time to overcome barriers to phage administration so more work like this can be done 💪 #IDSky
www.sciencedirect.com/science/arti...
Reposted by Rebecca Lester
Beautiful explainer on the simplicity and stability of Microbiology taxonomy.... 😅
#MicroSky #clinmicro #IDSky 🧪
#MicroSky #clinmicro #IDSky 🧪
Enterobacteriaceae? Enterobacterales?
What Should We Call Enteric Gram-Negative Bacilli? A Micro-Comic Strip #idsky #medsky #microsky
journals.asm.org/doi/10.1128/...
What Should We Call Enteric Gram-Negative Bacilli? A Micro-Comic Strip #idsky #medsky #microsky
journals.asm.org/doi/10.1128/...
November 28, 2024 at 10:06 AM
Beautiful explainer on the simplicity and stability of Microbiology taxonomy.... 😅
#MicroSky #clinmicro #IDSky 🧪
#MicroSky #clinmicro #IDSky 🧪
Reposted by Rebecca Lester
PhD studentship available.
The project is VERY interdisciplinary, combing social science, biophysics and microbiology to understand inequalities of UTIs treatment and replicate them in vitro to help choose the correct antibiotic.
Pls share, home students only #AMR #MicroSky
tinyurl.com/45d8h54u
The project is VERY interdisciplinary, combing social science, biophysics and microbiology to understand inequalities of UTIs treatment and replicate them in vitro to help choose the correct antibiotic.
Pls share, home students only #AMR #MicroSky
tinyurl.com/45d8h54u
Health inequalities which impact the treatment of urinary tract infections
Find out about this studentship opportunity on Health inequalities which impact the treatment of urinary tract infections.
tinyurl.com
November 19, 2024 at 2:05 PM
PhD studentship available.
The project is VERY interdisciplinary, combing social science, biophysics and microbiology to understand inequalities of UTIs treatment and replicate them in vitro to help choose the correct antibiotic.
Pls share, home students only #AMR #MicroSky
tinyurl.com/45d8h54u
The project is VERY interdisciplinary, combing social science, biophysics and microbiology to understand inequalities of UTIs treatment and replicate them in vitro to help choose the correct antibiotic.
Pls share, home students only #AMR #MicroSky
tinyurl.com/45d8h54u
Reposted by Rebecca Lester
🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure
High-risk ST131 E. coli strains, particularly C2/H30Rx subclades, adapt to initial carbapenem exposure by IS-mediated ESBL gene amplification. This gene am
academic.oup.com
November 28, 2024 at 6:46 AM
🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
Reposted by Rebecca Lester
Relax people - we have an extra 48hr to submit abstract to @escmid.bsky.social global! #IDSky #ESCMIDGlobal
#Icantgo 😢
#Icantgo 😢
Deadline extended for #ESCMIDGlobal 2025 abstract submission!
The new deadline is Friday, 29 Nov at 12:00 noon CET.
This extension applies to all abstract categories for the regular call and includes abstract-related grant and award applications.
ow.ly/YTu050UfLst
#IDsky #Clinmicro
The new deadline is Friday, 29 Nov at 12:00 noon CET.
This extension applies to all abstract categories for the regular call and includes abstract-related grant and award applications.
ow.ly/YTu050UfLst
#IDsky #Clinmicro
November 27, 2024 at 2:20 PM
Relax people - we have an extra 48hr to submit abstract to @escmid.bsky.social global! #IDSky #ESCMIDGlobal
#Icantgo 😢
#Icantgo 😢