Roberto Amadio
@ramadio.bsky.social
PostDoc @uniVerona. Hooked by cell biology | innate immunity | DNA sensing | genomics. Aspiring good scientist. Dabbling in education, music & #scicomm
Pinned
Roberto Amadio
@ramadio.bsky.social
· Feb 11
WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope
Mutations in the immune-specific actin regulator WASp induce a proinflammatory state in myeloid cells, whose underlying causes remain poorly defined. Here, we applied microfabricated tools that mimic ...
doi.org
Reposted by Roberto Amadio
Xun Cao, Yiming Peng, Mengyuan Yang, Daisuke Takao and colleagues (Huazhong Agricultural University) present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. rupress.org/jcb/article/...
November 21, 2025 at 8:15 PM
Xun Cao, Yiming Peng, Mengyuan Yang, Daisuke Takao and colleagues (Huazhong Agricultural University) present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. rupress.org/jcb/article/...
Reposted by Roberto Amadio
The physics behind the immune response: focus on viscoelasticity
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
Matrix viscoelasticity regulates dendritic cell migration and immune priming - preLights
The physics behind the immune response: focus on viscoelasticity
prelights.biologists.com
November 5, 2025 at 2:52 PM
The physics behind the immune response: focus on viscoelasticity
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
Reposted by Roberto Amadio
#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction
Necroptosis drives inflammation through membrane rupture-mediated DAMPs release. Independently
of membrane damage, Ding et al. revealed phosphorylated MLKL permeabilizes mitochondrial
membranes and in...
www.cell.com
July 19, 2025 at 4:56 PM
#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...
Reposted by Roberto Amadio
Macrophages sense and adapt.
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer - preLights
Macrophages sense and adapt. Immuno-mechanics meets cancer research
prelights.biologists.com
May 21, 2025 at 1:31 PM
Macrophages sense and adapt.
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
Reposted by Roberto Amadio
Targeting the root of NLRP3 inflammation 🎯
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action - preLights
Targeting the root of NLRP3 inflammation
prelights.biologists.com
February 14, 2025 at 9:51 AM
Targeting the root of NLRP3 inflammation 🎯
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
Reposted by Roberto Amadio
#MysterySolved! The Joshi lab &co show @science.org that KLF2 enables CD8 T cells to remain effector cells, proving that differentiation toward the exhaustion lineage is actively suppressed, with consequences for #tumor responses! #ScienceSavesLives www.science.org/doi/10.1126/...
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress d...
www.science.org
February 14, 2025 at 7:15 AM
#MysterySolved! The Joshi lab &co show @science.org that KLF2 enables CD8 T cells to remain effector cells, proving that differentiation toward the exhaustion lineage is actively suppressed, with consequences for #tumor responses! #ScienceSavesLives www.science.org/doi/10.1126/...
Reposted by Roberto Amadio
Hello everyone on Bluesky! 🧪
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
February 12, 2025 at 12:56 PM
Hello everyone on Bluesky! 🧪
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...