Roberto Amadio
@ramadio.bsky.social
PostDoc @uniVerona. Hooked by cell biology | innate immunity | DNA sensing | genomics. Aspiring good scientist. Dabbling in education, music & #scicomm
Pinned
Roberto Amadio
@ramadio.bsky.social
· Feb 11
WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope
Mutations in the immune-specific actin regulator WASp induce a proinflammatory state in myeloid cells, whose underlying causes remain poorly defined. Here, we applied microfabricated tools that mimic ...
doi.org
Reposted by Roberto Amadio
The physics behind the immune response: focus on viscoelasticity
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
Matrix viscoelasticity regulates dendritic cell migration and immune priming - preLights
The physics behind the immune response: focus on viscoelasticity
prelights.biologists.com
November 5, 2025 at 2:52 PM
The physics behind the immune response: focus on viscoelasticity
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
@ramadio.bsky.social covers a #mooneylab #preprint
"In this work, the authors devise a system capable of tuning viscoelasticity of collagen I independently of stiffness..."
#preLight ⬇️
prelights.biologists.com/highlights/m...
Reposted by Roberto Amadio
#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction
Necroptosis drives inflammation through membrane rupture-mediated DAMPs release. Independently
of membrane damage, Ding et al. revealed phosphorylated MLKL permeabilizes mitochondrial
membranes and in...
www.cell.com
July 19, 2025 at 4:56 PM
#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...
Reposted by Roberto Amadio
Macrophages sense and adapt.
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer - preLights
Macrophages sense and adapt. Immuno-mechanics meets cancer research
prelights.biologists.com
May 21, 2025 at 1:31 PM
Macrophages sense and adapt.
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
@ramadio.bsky.social highlights work from Xie & colleagues.
Roberto: “The huge amount of data presented in this preprint is of high value not only to cancer biologists, but also to cell biologists and clinicians”
#preLight ⬇️
prelights.biologists.com/highlights/a...
Reposted by Roberto Amadio
Targeting the root of NLRP3 inflammation 🎯
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action - preLights
Targeting the root of NLRP3 inflammation
prelights.biologists.com
February 14, 2025 at 9:51 AM
Targeting the root of NLRP3 inflammation 🎯
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds.”
#preLight by Roberto Amadio
prelights.biologists.com/highlights/d...
Reposted by Roberto Amadio
#MysterySolved! The Joshi lab &co show @science.org that KLF2 enables CD8 T cells to remain effector cells, proving that differentiation toward the exhaustion lineage is actively suppressed, with consequences for #tumor responses! #ScienceSavesLives www.science.org/doi/10.1126/...
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress d...
www.science.org
February 14, 2025 at 7:15 AM
#MysterySolved! The Joshi lab &co show @science.org that KLF2 enables CD8 T cells to remain effector cells, proving that differentiation toward the exhaustion lineage is actively suppressed, with consequences for #tumor responses! #ScienceSavesLives www.science.org/doi/10.1126/...
Reposted by Roberto Amadio
Hello everyone on Bluesky! 🧪
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
February 12, 2025 at 12:56 PM
Hello everyone on Bluesky! 🧪
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...
We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond.
Read more: www.embo.org/about-embo/m...