Pooja Middha
@poojamiddha.bsky.social
Genetic and Cancer Epidemiologist | Scientist at @RegeneronDNA | Alum @UCSFCancer, @dkfz, @UniHeidelberg, @umichsph | Views are my own 🇮🇳🇩🇪🇺🇸
Come check out our poster tomorrow on whole-exome sequencing of colitis adverse events in patients treated with immune checkpoint inhibitors #AACR25
@ucsfcancer.bsky.social
@mskcancercenter.bsky.social
@ucsfcancer.bsky.social
@mskcancercenter.bsky.social
April 28, 2025 at 2:11 AM
Come check out our poster tomorrow on whole-exome sequencing of colitis adverse events in patients treated with immune checkpoint inhibitors #AACR25
@ucsfcancer.bsky.social
@mskcancercenter.bsky.social
@ucsfcancer.bsky.social
@mskcancercenter.bsky.social
Thrilled to share our work on investigating the role of a polygenic risk score for overall autoimmunity in cessation of immune checkpoint inhibitor therapy for toxicities. bit.ly/3E3NkoX
@adamjschoenfeld.bsky.social
@ucsfcancer.bsky.social
@ucsfmedicine.bsky.social
@mskcancercenter.bsky.social
@adamjschoenfeld.bsky.social
@ucsfcancer.bsky.social
@ucsfmedicine.bsky.social
@mskcancercenter.bsky.social
Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events
Introduction Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors, but they also commonly cause immune-related adverse events (irAEs). T...
bit.ly
April 3, 2025 at 8:18 PM
Thrilled to share our work on investigating the role of a polygenic risk score for overall autoimmunity in cessation of immune checkpoint inhibitor therapy for toxicities. bit.ly/3E3NkoX
@adamjschoenfeld.bsky.social
@ucsfcancer.bsky.social
@ucsfmedicine.bsky.social
@mskcancercenter.bsky.social
@adamjschoenfeld.bsky.social
@ucsfcancer.bsky.social
@ucsfmedicine.bsky.social
@mskcancercenter.bsky.social
Excited to share our latest work exploring the role of germline genetics in the development of multiple primary cancers
@lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social
@lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social
📣Online now!
📄Unraveling the genetic landscape of susceptibility to multiple primary #cancers
🧑🤝🧑@johnwitte.bsky.social @poojamiddha.bsky.social & co
👉https://bit.ly/3WPyzfG
📄Unraveling the genetic landscape of susceptibility to multiple primary #cancers
🧑🤝🧑@johnwitte.bsky.social @poojamiddha.bsky.social & co
👉https://bit.ly/3WPyzfG
February 6, 2025 at 6:30 PM
Excited to share our latest work exploring the role of germline genetics in the development of multiple primary cancers
@lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social
@lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social
Reposted by Pooja Middha
Work by PhD student @jayatirsharma.bsky.social on how grouping Hispanic/Latino participants into a single group can obfuscate substantial substructure, leading to false conclusions.
We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.
We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.
New preprint! Within the HCHS/SOL study, we looked at the roles of self-identified background and genetic ancestry in describing GxE interactions of a PGS and sociocultural variables in a Hispanic/Latino population. www.medrxiv.org/content/10.1...
Influence of Genetic Ancestry on Gene-Environment Interactions of Polygenic Risk and Sociocultural Factors: Results from the Hispanic Community Health Study/Study of Latinos
Background Many present analyses of Hispanic/Latino populations in epidemiologic research aggregate all members of this ethnic group, despite immense diversity in genetic backgrounds, environment, and...
www.medrxiv.org
December 2, 2024 at 7:09 PM
Work by PhD student @jayatirsharma.bsky.social on how grouping Hispanic/Latino participants into a single group can obfuscate substantial substructure, leading to false conclusions.
We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.
We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.
Reposted by Pooja Middha
This paper was a long time coming, happy to see it out today in @naturecomms.bsky.social: www.nature.com/articles/s41...
We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬
We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival - Nature Communications
Glioma is an aggressive brain tumor subtype with few known risk factors. Here, the authors utilise Mendelian Randomisation to investigate correlation of immune cell counts with subtype-specific risk a...
www.nature.com
January 14, 2025 at 7:25 PM
This paper was a long time coming, happy to see it out today in @naturecomms.bsky.social: www.nature.com/articles/s41...
We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬
We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬
Reposted by Pooja Middha
As incoming chair of the young investigator committee of the International Genetic Epidemiology Society (IGES), I'd like to share a great opportunity for 5 Early Career Researchers to join the different IGES committees, deadline 31st Dec, details here: www.geneticepi.org/yic_position...
YIC_position openings
www.geneticepi.org
December 5, 2024 at 3:06 PM
As incoming chair of the young investigator committee of the International Genetic Epidemiology Society (IGES), I'd like to share a great opportunity for 5 Early Career Researchers to join the different IGES committees, deadline 31st Dec, details here: www.geneticepi.org/yic_position...
Reposted by Pooja Middha
One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj
November 26, 2024 at 3:54 AM
One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj
Reposted by Pooja Middha
These people made it all possible: @supportingswog.bsky.social
One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj
November 26, 2024 at 4:24 AM
These people made it all possible: @supportingswog.bsky.social
Reposted by Pooja Middha
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Pooja Middha
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
November 22, 2024 at 4:45 PM
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
Thrilled to see our work on genetic prediction of immune checkpoint inhibitor-mediated colitis published
t.co/nsCV47ahwl
t.co/nsCV47ahwl
Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis - Nature Communications
Colitis is one of the most common immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors. Here the authors show that a polygenic risk score for ulcerative coli...
t.co
March 27, 2024 at 6:30 PM
Thrilled to see our work on genetic prediction of immune checkpoint inhibitor-mediated colitis published
t.co/nsCV47ahwl
t.co/nsCV47ahwl
Reposted by Pooja Middha
Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric d...
A multivariate framework for isoform-resolution transcriptome-wide association studies enables modeling of a greater number of genes, with the benefit of identifying isoform-specific associations with...
www.nature.com
November 30, 2023 at 4:19 PM
Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pooja Middha
I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/
October 31, 2023 at 5:45 PM
I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/
Reposted by Pooja Middha
We’re back with a bigger and better GWAS of PSA levels! 🤩 We substantially increased sample size in African ancestry (+58k) and Hispanic/Latino (+23k) men, which translates into meaningful improvements in PRS performance
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
October 31, 2023 at 5:59 PM
We’re back with a bigger and better GWAS of PSA levels! 🤩 We substantially increased sample size in African ancestry (+58k) and Hispanic/Latino (+23k) men, which translates into meaningful improvements in PRS performance
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Pooja Middha
Trying to be better with sharing work on here 😅
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1
Glioma is a highly fatal brain tumor comprised of molecular subtypes with distinct clinical trajecto
www.medrxiv.org
October 16, 2023 at 5:51 PM
Trying to be better with sharing work on here 😅
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠