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PfamDB
@pfamdb.bsky.social
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The Pfam database is a large collection of protein families, domains and repeats. https://www.ebi.ac.uk/interpro/entry/pfam/#table
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pfamdb.bsky.social
PfamDB @pfamdb.bsky.social · Jun 20
🚀 HUGE NEWS: Pfam 37.4 is LIVE!
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
Pfam 37.4 318 new families 4 new clans Content Over 24,736 entries describing protein families, domains and repeats.
Reposted by PfamDB
europepmc.org
Open licenses power discovery!

Melissa Harrison shares a @pfamdb.bsky.social use case:

Pfam uses AI to extract information about known protein domains

This helps predict protein function & identify potential drug targets! 💊

#ChooseOpenWebinar for live updates 💡
#MedLib #PhDsky #OpenAccess
July 9, 2025 at 4:11 PM
Reposted by PfamDB
interprodb.bsky.social
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
🎤 Multiple talks & 📊 posters on protein analysis & classification
💻🧪
Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI InterProScan 6: a modern large-scale protein function annotation pipeline Matthias Blum 21/07/2025 14:20 Room 03A Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation Emma Hobbs Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI Accelerating protein family classification in InterPro with AI innovations Matthias Blum 22/07/2025 16:40 Room 12 Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
July 18, 2025 at 2:11 PM
Reposted by PfamDB
interprodb.bsky.social
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
Join us July 20-24 at the world's largest #bioinformatics conference!
#ISMBECCB2025 #ProteinAnalysis #ComputationalBiology
💻🧪
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
July 18, 2025 at 2:09 PM
pfamdb.bsky.social
Come chat to us at @jobim2025.bsky.social!
interprodb.bsky.social InterPro @interprodb.bsky.social · Jul 7
🧬✨ Excited to present at @jobim2025.bsky.social this week in Bordeaux!
🎤 Talk 08/07 16:50, amphi E: Pfam: embracing AI/ML by @typhainepl.bsky.social
📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum.bsky.social
💻🧪
JOBIM 2025 logo 8 to 11th July 2025 Bordeaux
July 7, 2025 at 8:24 AM
Reposted by PfamDB
europepmc.org
Can AI train on my openly licensed research? Do I retain copyright if I choose a CC BY license? Why can’t I reuse a figure from my own paper?

Get the answers in a webinar with Creative Commons, #EuropePMC & EMBL

🗓️ 9 Jul
⏰ 15:00 UTC
🔗 embl-org.zoom.us/webinar/regi...

#OpenScience #AcademicSky 🧪
Promotional slide for a webinar titled "What happens when you choose closed? What Creative Commons licenses mean for research and AI." The slide features photos and names of five speakers: Melissa Harrison (Europe PMC / EMBL-EBI), Katherine Hughes (EMBL), Taylor Campbell (Creative Commons), Monica Granados (Creative Commons), and Kat Walsh (Creative Commons). Logos for Europe PMC, Creative Commons, and EMBL are shown at the bottom. The background is green with white text.
June 23, 2025 at 9:02 AM
pfamdb.bsky.social
🚀 HUGE NEWS: Pfam 37.4 is LIVE!
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
Pfam 37.4 318 new families 4 new clans Content Over 24,736 entries describing protein families, domains and repeats.
June 20, 2025 at 8:47 AM
Reposted by PfamDB
interprodb.bsky.social
🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
InterPro 106.0 19th June 2025 Databases updates: Pfam 37.4 New entries: 683 new entries with: 613 Pfam 78 NCBIfam 30 CDD 4 PANTHER ...
June 20, 2025 at 8:23 AM
Reposted by PfamDB
pdbeurope.bsky.social
What’s new in the redesigned PDBe entry pages?

🧪 Cleaner layout
🧪 Interactive 3D viewers
🧪 Contextual annotations
🧪 Easier navigation

See for yourself:
wwwdev.ebi.ac.uk/pdbe/entry/p...

#PDBeBeta #Bioinformatics #Biochemistry #Science
June 16, 2025 at 3:40 PM
Reposted by PfamDB
interprodb.bsky.social
🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro!
1.8 billion AI-driven protein annotations developed with Google DeepMind are now live.
✨ Look for the sparkles icon to identify them
📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked
💻🧪
May 15, 2025 at 5:08 PM
Reposted by PfamDB
interprodb.bsky.social
🔍 NEW: TED domains in InterPro 105.0!

For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪

Explore now: www.ebi.ac.uk/interpro/pro...
TED domains alongside InterPro annotations for UniProt P05067
May 8, 2025 at 2:55 PM
Reposted by PfamDB
interprodb.bsky.social
📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0!
Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...
InterPro 105.0: AI for protein classification InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe
May 1, 2025 at 4:35 PM
pfamdb.bsky.social
🔥 Pfam 37.3 just dropped! 🚀
353 incredible new protein families + 7 new clans! 🧬✨
Revolutionise your research NOW via @interprodb.bsky.social website, API & Pfam FTP!
April 25, 2025 at 8:24 AM
Reposted by PfamDB
interprodb.bsky.social
📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
InterPro 105.0 24th April 2025 Databases updates Pfam 37.3 PROSITE patterns 2025_01 PROSITE profiles 2025_01 HAMAP 2025_01 New entries 342 new entries with: 318 Pfam 40 NCBIfam 12 Prosite profiles 6 PANTHER 5 CDD New features InterPro-N annotations BFVD structure predictions Simplified structure pages
April 24, 2025 at 4:07 PM
Reposted by PfamDB
interprodb.bsky.social
Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪
training.ebi.embl.org EMBL-EBI Training @training.ebi.embl.org · Mar 25
Would you like to learn how to use @ebi.embl.org resources for #protein characterisation? This one-day workshop will show you how to retrieve protein sequences, identify homologs, annotate functional domains, and explore structural information using REST APIs: ebi.ac.uk/training/eve...

🧶🧬🖥️🧪
Course at EMBL-EBI From sequences to structures Protein characterisation using EMBL-EBI APIs 5 June 2025 Virtual
April 2, 2025 at 9:36 AM
Reposted by PfamDB
interprodb.bsky.social
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
InterPro 104.0 6th February 2025 Databases udpates: Pfam 37.2, NCBIfam 17.0, CDD 3.21 661 new entries, containing: 663 Pfam 5 NCBIfam 5 PANTHER 9 CDD New features: Redesigned protein viewer for sequence searches Wikipedia articles for Pfam clans Addition of PTM from the PRIDE database
February 6, 2025 at 2:19 PM
pfamdb.bsky.social
Pfam 37.2 is out 🎉It contains 302 new families and 18 new clans You can have a look at them in InterPro: ebi.ac.uk/interpro/ent... or download the release from the Pfam ftp: ftp.ebi.ac.uk/pub/database...
Pfam 37.2: 302 new families and 18 new clans
February 6, 2025 at 2:46 PM
pfamdb.bsky.social
🔍 Lost in Pfam data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪
InterPro website (home of Pfam) Help page
January 24, 2025 at 11:04 AM
Reposted by PfamDB
ebi.embl.org
Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬

But things get more challenging for protein families.

A new method helps improve low confidence predictions within protein families.

academic.oup.com/bioinformati...
Protein structure prediction from the AlphaFold Database
December 16, 2024 at 9:28 AM
Reposted by PfamDB
interprodb.bsky.social
🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility.
1) Curation data are now in Overview
2) HMM information and logo are now in Profile HMM
Have a look: www.ebi.ac.uk/interpro/ent...
Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo
January 16, 2025 at 11:39 AM
Reposted by PfamDB
training.ebi.embl.org
Welcome to 2025 🎉 We are running a number of exciting courses this year, so join us to boost your #bioinformatics, #datascience and #omics skills!

These courses are currently open for applications - find out more: www.ebi.ac.uk/training/liv...

💻🧬💻🧪
Cancer genomics and transcriptomics. Virtual. Closes 9 February. Introduction to metabolomics analysis. Hinxton. Closes 2 Feburary. Data science for life scientists. Hinxton. Closes 2 March. Data visualisation for biology. Hinxton. Closes 9 March. Systems biology: from large datasets to biological insight. Hinxton. Closes 16 March.
January 6, 2025 at 11:28 AM
Reposted by PfamDB
atsocf.bsky.social
Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @pfamdb.bsky.social
domains. doi.org/10.1093/bioa... 1/7
Keeping it in the family: using protein family templates to rescue low confidence AlphaFold2 models
AbstractMotivation. High confidence structure prediction models have become available for nearly all protein sequences. More than 200 million AlphaFold2 mo
doi.org
December 9, 2024 at 1:57 PM
pfamdb.bsky.social
🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...
Pfam 37.1 release
Pfam 37.1 release is now out and accessible through the InterPro website and Pfam ftp.  More frequent Pfam updates Historically, Pfam releases occurred approximately once per year. With the de…
xfam.wordpress.com
December 9, 2024 at 9:58 AM
pfamdb.bsky.social
For the latest Pfam updates, have a look at our recently published paper: The Pfam protein families database: embracing AI/ML
t.co/8auCxw3mdj
NAR graphical abstract: Pfam coverage Using AlphaFold to build new Pfam domains Use of deep learning to Increase coverage of UniProtKB Improved coverage of repeated domains
November 29, 2024 at 9:59 AM
Reposted by PfamDB
interprodb.bsky.social
InterPro release 103.0 is live! 💻🧪
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
InterPro release 103.0: 28th November 2024 Database updates: Pfam 37.1 1029 new entries containing: 1008 Pfam 2 NCBIfam 1 PIRSF 1 PANTHER 7 CDD New features: Redesigned protein viewer Improved dataset browsing Streamlined website navigation Member database entry page updates
November 29, 2024 at 8:29 AM
pfamdb.bsky.social
We’re delighted to have joined BlueSky to engage with the scientific community about protein families, protein domains and related data. The Pfam database is a large collection of protein families, domains and repeats.
Pfam: collection of protein families and domains Content: Over 21,000 entries describing protein families, domains and repeats. Training available on the EMBL-EBI training platform
November 20, 2024 at 10:10 AM