Overjoyed to finally have our isopeptide bond paper out! If you're interested in the types of proteins and organisms that use a cool intramolecular covalent bond, check it out:

bit.ly/4od3ux8

Plenty of future SynBio/EngBio applications planned! Thanks to all involved (character limits suck).

⚠️⚠️⚠️Preprint alert⚠️⚠️⚠️
We mapped intramolecular isopeptide bonds across the AlphaFold database and found that they are widely distributed in microbial surface proteins, such as fibrillar adhesins or pilins, suggesting new targets for broad-spectrum antimicrobial strategies.

📢 Just published! Introducing Isopeptor: a computational tool for detecting intramolecular isopeptide bonds in protein structures with high precision and recall.
academic.oup.com/bioinformati...

Check out this article about my research at @embl.org where I focus on protein modelling and on the study of fibrillar adhesins. Recently, we developed a method to detect isopeptide bonds, a key stabilizing feature in bacterial proteins. Thanks @oanastroe.bsky.social for putting this together!👇 👇 👇

Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬

But things get more challenging for protein families.

A new method helps improve low confidence predictions within protein families.

academic.oup.com/bioinformati...

Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @pfamdb.bsky.social
domains. doi.org/10.1093/bioa... 1/7