Paul Ettel
@pettel.bsky.social
Immunologist - neutrophils, macrophages, immunometabolism
PhD student with Thomas Weichhart @ Medical University of Vienna | MD by training
PhD student with Thomas Weichhart @ Medical University of Vienna | MD by training
Pinned
Paul Ettel
@pettel.bsky.social
· Nov 19
Not just sugar: metabolic control of neutrophil development and effector functions
We discuss how neutrophilic metabolism adapts during development, which metabolic pathways fuel their functionality, and how these processes are reconfigur
academic.oup.com
My (little) take on how metabolism regulates neutrophil development and functions and why it should be studied more. Happy if it is helpful to anyone interested!
academic.oup.com/jleukbio/art...
academic.oup.com/jleukbio/art...
Reposted by Paul Ettel
Reposted by Paul Ettel
Not turbo cancer but turbo cancer-immunotherapy!
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
October 22, 2025 at 6:51 PM
Not turbo cancer but turbo cancer-immunotherapy!
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Paul Ettel
Niche-specific dermal macrophage loss promotes skin capillary ageing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 15, 2025 at 5:30 PM
Niche-specific dermal macrophage loss promotes skin capillary ageing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paul Ettel
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 11:28 AM
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paul Ettel
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Paul Ettel
Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!
July 14, 2025 at 8:42 PM
Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!
Very happy to finally share the news that I am among this year's Early Career Fellowship Grant recipients by the Foundation of Sarcoidosis Research.
www.globenewswire.com/news-release...
www.globenewswire.com/news-release...
The Foundation for Sarcoidosis Research Awards $450,000 to Support Early-Career Investigators Through the 2025 Fellowship Grant
FSR Early Career Fellowship Grant is designed to support early-career investigators in sarcoidosis....
www.globenewswire.com
July 14, 2025 at 6:34 PM
Very happy to finally share the news that I am among this year's Early Career Fellowship Grant recipients by the Foundation of Sarcoidosis Research.
www.globenewswire.com/news-release...
www.globenewswire.com/news-release...
Reposted by Paul Ettel
Amitava Sinha via the @preprintclub.bsky.social wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
www.nature.com
July 8, 2025 at 7:06 AM
Amitava Sinha via the @preprintclub.bsky.social wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Reposted by Paul Ettel
CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
May 15, 2025 at 5:04 PM
CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments.
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
What a great conference in Crete! Very happy to be among the travel award recipients! See you in two years :))
Congratulations to all the award recipients. Bravo! 6th Int’l Conference on #ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism. Crete, Greece
May 11, 2025 at 11:04 AM
What a great conference in Crete! Very happy to be among the travel award recipients! See you in two years :))
This is just great
Matrix-producing neutrophils ‘bandage’ wounds with bacteria-trapping goo @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
March 19, 2025 at 6:45 PM
This is just great
Reposted by Paul Ettel
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
February 24, 2025 at 6:38 AM
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance!
📖 shorturl.at/WkTgq
📖 shorturl.at/WkTgq
Good one!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cooperative nutrient scavenging is an evolutionary advantage in cancer - Nature
Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.
www.nature.com
February 19, 2025 at 5:48 PM
Good one!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Paul Ettel
With my first Bluesky post, I am very happy to share our latest study led by PhD student Federico De Ponti and postdoc Ania Bujko www.cell.com/immunity/ful...
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but
their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and
resident LAM-like KCs in multiple l...
www.cell.com
January 24, 2025 at 6:46 PM
With my first Bluesky post, I am very happy to share our latest study led by PhD student Federico De Ponti and postdoc Ania Bujko www.cell.com/immunity/ful...
Reposted by Paul Ettel
www.immunometabolism.at/job-openings...
great opportunity to discover new aspects of immunometabolism...
great opportunity to discover new aspects of immunometabolism...
CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
www.immunometabolism.at
January 10, 2025 at 11:29 AM
www.immunometabolism.at/job-openings...
great opportunity to discover new aspects of immunometabolism...
great opportunity to discover new aspects of immunometabolism...
SFB Immunometabolism Austria is looking for PhD students and postdocs. Highly recommended to join the team! Happy to answer any questions.
#immunometabolism #phd #postdoc
www.immunometabolism.at/job-openings/
#immunometabolism #phd #postdoc
www.immunometabolism.at/job-openings/
CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
www.immunometabolism.at
January 10, 2025 at 11:28 AM
SFB Immunometabolism Austria is looking for PhD students and postdocs. Highly recommended to join the team! Happy to answer any questions.
#immunometabolism #phd #postdoc
www.immunometabolism.at/job-openings/
#immunometabolism #phd #postdoc
www.immunometabolism.at/job-openings/
Reposted by Paul Ettel
1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".
Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:
arxiv.org/abs/2501.00536
Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:
arxiv.org/abs/2501.00536
January 4, 2025 at 9:34 AM
1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".
Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:
arxiv.org/abs/2501.00536
Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:
arxiv.org/abs/2501.00536
Reposted by Paul Ettel
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Great paper by @ejvillablanca.bsky.social on LXR gut repair and tumorigenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
www.nature.com
November 20, 2024 at 5:38 PM
Great paper by @ejvillablanca.bsky.social on LXR gut repair and tumorigenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
My (little) take on how metabolism regulates neutrophil development and functions and why it should be studied more. Happy if it is helpful to anyone interested!
academic.oup.com/jleukbio/art...
academic.oup.com/jleukbio/art...
Not just sugar: metabolic control of neutrophil development and effector functions
We discuss how neutrophilic metabolism adapts during development, which metabolic pathways fuel their functionality, and how these processes are reconfigur
academic.oup.com
November 19, 2024 at 4:45 PM
My (little) take on how metabolism regulates neutrophil development and functions and why it should be studied more. Happy if it is helpful to anyone interested!
academic.oup.com/jleukbio/art...
academic.oup.com/jleukbio/art...