Peter Krenn
@petkrenn.bsky.social
Fascinated by Nature. Scientist at the University of Salzburg. Dedicated to understanding and targeting leukemic stem cell interactions to advance cancer therapy, specializing in spatial biology and adhesion molecules.
Reposted by Peter Krenn
🚀 Prophet v3 is out!
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
November 4, 2025 at 5:40 PM
🚀 Prophet v3 is out!
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
Reposted by Peter Krenn
Less than a week left to apply!
Join the spaXio Doctoral Network, where we’re decoding the biology of metastasis through spatial omics, organoid models, and computational biology.
Don’t miss your chance to be part of this cutting-edge research community.
Apply now: www.spaXio.eu
Join the spaXio Doctoral Network, where we’re decoding the biology of metastasis through spatial omics, organoid models, and computational biology.
Don’t miss your chance to be part of this cutting-edge research community.
Apply now: www.spaXio.eu
Join spaXio, an EU-funded MSCA Doctoral Network exploring how cancer spreads & interacts with its surroundings using spatial multi-omics, 3D tumoroids, advanced imaging & AI.
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
November 4, 2025 at 11:15 AM
Less than a week left to apply!
Join the spaXio Doctoral Network, where we’re decoding the biology of metastasis through spatial omics, organoid models, and computational biology.
Don’t miss your chance to be part of this cutting-edge research community.
Apply now: www.spaXio.eu
Join the spaXio Doctoral Network, where we’re decoding the biology of metastasis through spatial omics, organoid models, and computational biology.
Don’t miss your chance to be part of this cutting-edge research community.
Apply now: www.spaXio.eu
Reposted by Peter Krenn
Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪
Better understanding of laboratory animal genetics will improve reproducibility
Incomplete characterization and inconsistent reporting of laboratory animal genetics undermine study quality and limit research reproducibility. This Perspective highlights the LAG-R guidelines and…
plos.io
October 31, 2025 at 1:58 PM
Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪
Reposted by Peter Krenn
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Peter Krenn
Join spaXio, an EU-funded MSCA Doctoral Network exploring how cancer spreads & interacts with its surroundings using spatial multi-omics, 3D tumoroids, advanced imaging & AI.
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
October 17, 2025 at 8:05 AM
Join spaXio, an EU-funded MSCA Doctoral Network exploring how cancer spreads & interacts with its surroundings using spatial multi-omics, 3D tumoroids, advanced imaging & AI.
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
🎓 14 fully funded PhD positions across Europe!
🌐 www.spaXio.eu
📝 Apply: civis.smapply.io/prog/spaxio_...
Reposted by Peter Krenn
ICYMI: New Online! SLAM passes the haematopoietic stem cell identity test
SLAM passes the haematopoietic stem cell identity test
Nature Reviews Molecular Cell Biology, Published online: 02 October 2025; doi:10.1038/s41580-025-00906-4Christina Termini highlights the importance of the identification of haematopoietic stem cell markers.
bit.ly
October 5, 2025 at 12:07 PM
ICYMI: New Online! SLAM passes the haematopoietic stem cell identity test
Reposted by Peter Krenn
🚨 New preprint alert! 🚨
We just posted our latest manuscript on patient-derived xenograft (PDX) models in acute myeloid leukemia (AML):
📝 "A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist"
www.biorxiv.org/content/10.1...
Why this matters ⬇️
We just posted our latest manuscript on patient-derived xenograft (PDX) models in acute myeloid leukemia (AML):
📝 "A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist"
www.biorxiv.org/content/10.1...
Why this matters ⬇️
A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist
Preclinical cancer research requires robust model systems, especially for poor prognosis entities like acute myeloid leukemia (AML), a highly aggressive blood cancer. Here, primary tumor cells from 13...
www.biorxiv.org
September 29, 2025 at 9:44 AM
🚨 New preprint alert! 🚨
We just posted our latest manuscript on patient-derived xenograft (PDX) models in acute myeloid leukemia (AML):
📝 "A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist"
www.biorxiv.org/content/10.1...
Why this matters ⬇️
We just posted our latest manuscript on patient-derived xenograft (PDX) models in acute myeloid leukemia (AML):
📝 "A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist"
www.biorxiv.org/content/10.1...
Why this matters ⬇️
Reposted by Peter Krenn
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 12:01 PM
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Reposted by Peter Krenn
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
September 28, 2025 at 5:50 PM
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by Peter Krenn
“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in @jcellsci.bsky.social, worth a read!
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
The integrin odyssey – a journey full of fundamental discoveries
Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.
journals.biologists.com
September 25, 2025 at 11:02 PM
“The integrin odyssey – a journey full of fundamental discoveries” by Fässler and Sonnenberg in @jcellsci.bsky.social, worth a read!
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Peter Krenn
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 7:36 PM
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
What a step forward for spatial biology! Combining RNA profiling with DNA methylation detection while maintaining tissue context is pure awesomeness! A must read 🔍 www.nature.com/articles/s41...
Spatial joint profiling of DNA methylome and transcriptome in tissues - Nature
DNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription interact to shape ...
www.nature.com
September 3, 2025 at 7:43 PM
What a step forward for spatial biology! Combining RNA profiling with DNA methylation detection while maintaining tissue context is pure awesomeness! A must read 🔍 www.nature.com/articles/s41...
Reposted by Peter Krenn
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Peter Krenn
spaXio members were proud to take part in the Summer School "Immuno-Oncology in the Spatial Omics Era", hosted by the Institut Cancer et Immunologie (ICI) Marseille and CIVIS. It was a fantastic week filled with cutting-edge scientific talks, hands-on workshops, and inspiring student presentations.
July 12, 2025 at 10:43 AM
spaXio members were proud to take part in the Summer School "Immuno-Oncology in the Spatial Omics Era", hosted by the Institut Cancer et Immunologie (ICI) Marseille and CIVIS. It was a fantastic week filled with cutting-edge scientific talks, hands-on workshops, and inspiring student presentations.
Reposted by Peter Krenn
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
www.nature.com
May 26, 2025 at 12:16 PM
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Reposted by Peter Krenn
Big news from Uni Salzburg! The Xenium spatial transcriptomics platform is up and running. Supported by FFG-backed CellComm initiative, Centre for Tumour Biology and Immunology and Dept of Biosciences and Med.Biology, this tech brings next-level spatial resolution to our cancer research efforts!
April 30, 2025 at 4:25 PM
Big news from Uni Salzburg! The Xenium spatial transcriptomics platform is up and running. Supported by FFG-backed CellComm initiative, Centre for Tumour Biology and Immunology and Dept of Biosciences and Med.Biology, this tech brings next-level spatial resolution to our cancer research efforts!
What a day! First our granted MSCA doctoral network spaXio @spaxio.bsky.social, now my first last authorship! Perfect timing as we will need to do some serious organoid manipulations to achieve our spaXio goals!
Check out our protocol: pubmed.ncbi.nlm.nih.gov/40163310
Check out our protocol: pubmed.ncbi.nlm.nih.gov/40163310
April 2, 2025 at 8:16 PM
What a day! First our granted MSCA doctoral network spaXio @spaxio.bsky.social, now my first last authorship! Perfect timing as we will need to do some serious organoid manipulations to achieve our spaXio goals!
Check out our protocol: pubmed.ncbi.nlm.nih.gov/40163310
Check out our protocol: pubmed.ncbi.nlm.nih.gov/40163310
Reposted by Peter Krenn
Thrilled to announce our doctoral network for spatial oncology as been funded by Marie Skłodowska-Curie Actions! This combines some of the best immuno-oncology and computational labs across Europe to create a multi-disciplinary PhD program for spatial-omics cancer research. More details soon!
April 2, 2025 at 12:20 PM
Thrilled to announce our doctoral network for spatial oncology as been funded by Marie Skłodowska-Curie Actions! This combines some of the best immuno-oncology and computational labs across Europe to create a multi-disciplinary PhD program for spatial-omics cancer research. More details soon!
Exciting computational workflow and a step towards understanding the ACTUAL composition of celltype specific niches. www.nature.com/articles/s41...
Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution - Nature Communications
Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, the authors develop scNiche, a computational framework to identify and characterise cel...
www.nature.com
February 20, 2025 at 9:38 PM
Exciting computational workflow and a step towards understanding the ACTUAL composition of celltype specific niches. www.nature.com/articles/s41...