Toni Petan
@petanlab.bsky.social
Scientist interested in lipids, membranes and cell biology working at Jožef Stefan Institute in Ljubljana, Slovenia; Assoc. Prof. at Jozef Stefan Postgraduate School; Lipid droplets, membranes, cell biology, ferroptosis, autophagy, cancer.
Reposted by Toni Petan
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
www.nature.com
November 17, 2025 at 10:57 PM
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toni Petan
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting
of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor
Ldo16. They uncover a molecular l...
www.cell.com
November 7, 2025 at 2:06 PM
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
Reposted by Toni Petan
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
www.nature.com
November 5, 2025 at 4:11 PM
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toni Petan
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning
Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...
portlandpress.com
October 31, 2025 at 9:53 AM
Curious how proteins find their way to #LipidDroplets?
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Our bipartite review traces their journey from ER insertion to LD partitioning:
👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning
#Organelles
#EndoplasmicReticulum
#ER_Literature
Reposted by Toni Petan
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Toni Petan
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis - Nature Chemistry
Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.
www.nature.com
September 26, 2025 at 4:39 PM
very interesting study from Gonzalo Cosa's lab adding to the discussion of ferroptosis initiations and propagation www.nature.com/articles/s41...
will there be a consensus? does it really matter? more studies definitely needed to settle this
will there be a consensus? does it really matter? more studies definitely needed to settle this
Reposted by Toni Petan
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
lnkd.in/dgsW4c3
Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026
October 9, 2025 at 6:42 AM
This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!
Reposted by Toni Petan
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Toni Petan
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Toni Petan
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...
www.biorxiv.org
August 6, 2025 at 3:21 PM
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Toni Petan
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
www.biorxiv.org
August 6, 2025 at 8:38 AM
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Reposted by Toni Petan
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1
August 6, 2025 at 8:30 AM
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1
Reposted by Toni Petan
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1
August 6, 2025 at 8:30 AM
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1
Reposted by Toni Petan
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
A checklist for designing and improving the visualization of scientific data
Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...
rdcu.be
June 18, 2025 at 8:33 AM
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
Reposted by Toni Petan
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Reposted by Toni Petan
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
May 13, 2025 at 8:40 AM
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
Reposted by Toni Petan
Abstracts are being accepted for #FOLSCR, a brand-new conference exploring a new form of cell death. With @ginadenicola.bsky.social and @brentstockwell.bsky.social, this may be one of FASEB's biggest new conferences. Submit your research by June 1 and save your space: buff.ly/HB3PDmS
May 10, 2025 at 9:53 PM
Abstracts are being accepted for #FOLSCR, a brand-new conference exploring a new form of cell death. With @ginadenicola.bsky.social and @brentstockwell.bsky.social, this may be one of FASEB's biggest new conferences. Submit your research by June 1 and save your space: buff.ly/HB3PDmS
Reposted by Toni Petan
#FOLSCR is a new conference exploring all aspects of a form of cell death that results from iron accumulation and lipid peroxidation. Hear keynotes @ginadenicola.bsky.social and @brentstockwell.bsky.social with organizers Scott Dixon and @olzmannlab.bsky.social. Save your space: buff.ly/MmJsYQq
April 25, 2025 at 2:56 PM
#FOLSCR is a new conference exploring all aspects of a form of cell death that results from iron accumulation and lipid peroxidation. Hear keynotes @ginadenicola.bsky.social and @brentstockwell.bsky.social with organizers Scott Dixon and @olzmannlab.bsky.social. Save your space: buff.ly/MmJsYQq