Paul A. Welling, MD
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pawellingmd.bsky.social
Paul A. Welling, MD
@pawellingmd.bsky.social
1.2K followers 570 following 61 posts
MD-Scientist Professor, Physiologist exploring molecular mechanisms of sodium-potassium balance, hypertension & kidney disease. Hobbies: Travel, Golf, Food, Wine & Spirits, Biking, O's fan

Johns Hopkins School of Medicine
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Paul A. Welling, MD @pawellingmd.bsky.social · Dec 31
The Aldosterone Paradox: A Skeetutorial:
a man stands in front of a blackboard with the words it 's paradoxical and yet it works
ALT: a man stands in front of a blackboard with the words it 's paradoxical and yet it works
media.tenor.com
Reposted by Paul A. Welling, MD
apspublications.bsky.social
🌟 Call for Applications for Editor-in-Chief of AJP-Heart and Circ 🌟

We're looking for an engaging and dynamic Editor who will be actively involved in shaping the strategic direction of the journal. To submit your application ➡️ https://ow.ly/AkAp50XC57C

American Physiological Society
December 5, 2025 at 2:30 PM
Reposted by Paul A. Welling, MD
apspublications.bsky.social
🌟 Call for Applications for Editor-in-Chief of Physiological Reviews🌟

We're looking for an engaging & dynamic Editor to actively commission Reviews from high impact authors across all areas of #physiology. https://ow.ly/2oSy50XC4Nb

American Physiological Society
December 4, 2025 at 7:05 PM
Reposted by Paul A. Welling, MD
apspublications.bsky.social
Congrats to Diogo Manoel, et. al, for the #APSselect paper "Functional characterization and cAMP-mediated rescue of a novel truncating AVPR2 mutation causing nephrogenic diabetes insipidus" in @AJPEndoMetab
@saraivalmr @saraivalab @sidramedicine

https://ow.ly/c38u50XFNEc
December 8, 2025 at 4:40 PM
Reposted by Paul A. Welling, MD
asnpublications.bsky.social
This #ASNJASN research explored how two transcription factors, Dmrt2 and Hmx2, influence the differentiation of intercalated cells in the kidney, which are crucial for acid-base balance. Read more: kidney.pub/JASN0885 #BasicScience
December 4, 2025 at 3:00 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
Physiology provides the foundation every medical advancement depends on. Our Physiology: The Science Life Depends On campaign elevates awareness of physiology’s crucial role in science and advocates for sustained research funding. Learn more at fightforphysiology.org #FightForPhysiology🧪
Young child with brown hair looking sideways under text about the importance of physiology in science and life.
December 1, 2025 at 2:00 PM
Reposted by Paul A. Welling, MD
nature.com
Five years ago, researchers at Google DeepMind unveiled AlphaFold2

go.nature.com/3M1Tvxx
AlphaFold is five years old — these charts show how it revolutionized science
Nature - Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
go.nature.com
December 1, 2025 at 6:09 PM
pawellingmd.bsky.social
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | Amer...
We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule ...
journals.physiology.org
November 27, 2025 at 7:22 PM
pawellingmd.bsky.social
The clathrin adaptor ARH not only targets LDL for endocytosis but also mediates the internalization of the key kidney potassium excretory channels, ROMK and BK. Here, we show why people who lack functional ARH do not waste potassium in their urine. journals.physiology.org/doi/full/10....
The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK | American Journal of Physiology-Renal Physiology | American Physiological Society
Renal outer medullary K+ (ROMK) channels are essential for urinary potassium secretion, and their endocytosis prevents excessive K+ loss during dietary deficiency. The clathrin adaptor autosomal reces...
journals.physiology.org
November 18, 2025 at 8:12 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
ICYMI, last week we launched "Physiology: The Science Life Depends On," a campaign to champion the discipline and protect the science behind every breakthrough. Our goal: to reintroduce physiology to the world. Learn more and join the #FightForPhysiology: fightforphysiology.org 🧪
Portrait of an elderly person outdoors with text promoting progress in physiology science. The text reads The Science Life Depends On. Let's drive physiology forward.
November 10, 2025 at 2:01 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
Today, APS is launching Physiology: The Science Life Depends On, a campaign to champion #physiology and protect the science behind every breakthrough. It's time to reintroduce physiology to the world, together. Join the #FightForPhysiology at fightforphysiology.org 🧪
A young child with brown hair looks off to the side with a thoughtful expression against a soft gray background. Above her, bold text reads: “The science life depends on. Let’s drive physiology forward.” The word “life” is written in colorful script, and “physiology” is underlined in pink.
November 6, 2025 at 3:30 PM
Reposted by Paul A. Welling, MD
hswapnil.medsky.social
Is it not really TGF - and something else in the tubules?

Fascinating Biomarker study in @ajkd.bsky.social from the EMPA-KIDNEY group

www.ajkd.org/article/S027...

cc @pranavgarimella.bsky.social

#NephSky #RevengeOfTheTubules
Figure 1 Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.
October 31, 2025 at 10:36 PM
Reposted by Paul A. Welling, MD
asnpublications.bsky.social
This #ASNCJASN original research identified ten plasma proteins associated with dietary potassium and CKD risk in a US adult population, highlighting mechanisms involving iron deposition, mitochondrial function, inflammation, and fibrosis. Read more: kidney.pub/CJASN0864

@pawellingmd.bsky.social
October 28, 2025 at 6:00 PM
Reposted by Paul A. Welling, MD
asnpublications.bsky.social
A randomized controlled trial in #ASNJASN finds that adjuvant thiazide improved diuretic response more than loop dose increased in patients with acute heart failure and diuretic resistance. Read more: kidney.pub/JASN0887

@pawellingmd.bsky.social

October 16, 2025 at 7:00 PM
Reposted by Paul A. Welling, MD
nejm.org
BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ
A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.
October 15, 2025 at 7:02 PM
Reposted by Paul A. Welling, MD
nejm.org
In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 across the overall cohort and in various subgroups. Full study results: nej.md/47anKdz

#MedSky #IDSky
A graph showing the Covid-19–associated composite outcome over 180 days in the 2024–2025 vaccination season
October 8, 2025 at 9:10 PM
Reposted by Paul A. Welling, MD
hswapnil.medsky.social
The unregulated and unscrupulous medical hydration spa industry

www.medscape.com/viewarticle/... with @fperrywilson.bsky.social
What ‘Secret Shoppers’ Discovered About IV Hydration Spas
Researchers posed as potential clients to examine the practices and regulation of the burgeoning intravenous hydration spa industry.
www.medscape.com
October 7, 2025 at 12:53 AM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
It's time! The #APS2026 abstract portal is open! Submit your best work through 12/3 and we'll see you in Minneapolis in April: https://ow.ly/EjFJ50X4p89 #WeArePhysiology 🧪
Logo for the American Physiology Summit with event dates April 23-26, 2026, held in Minneapolis.
October 1, 2025 at 1:01 PM
Reposted by Paul A. Welling, MD
vscooper.micropopbio.org
Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting..

Microbiologists! 🧫🦠🔬🧪

Please apply to join our faculty and enjoy these views 👀 while doing great science

cfopitt.taleo.net/careersectio...
August 21, 2025 at 3:19 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
#BornThis Day in 1896, Gerty Cori was the first American woman to receive the 1947 #NobelPrize in #Physiology or Medicine (with scientist-husband Carl). Their work: How the body metabolizes sugar. More from @jwaonline.bsky.social: ow.ly/7YBR50WFiWz #ISpyPhysiology 🧪
A woman in a lab coat holds up a test tube for examination while a man in a lab coat stands beside her. They are surrounded by glassware, beakers, and scientific equipment in a laboratory setting.
August 15, 2025 at 7:00 PM
pawellingmd.bsky.social
The George M. O’Brien Kidney Resource Alliance announces its 3rd Opportunity Pool Program, supporting pilot grants (up to a maximum of $50,000 total costs) that address scientific and technological gaps in kidney research and promote new collaborations. www.uab.edu/okra/funding...
OKRA Opportunity Pool Program - George M. O’Brien Kidney Resource Alliance
www.uab.edu
August 14, 2025 at 4:15 PM
Reposted by Paul A. Welling, MD
peiferlabunc.bsky.social
NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at:
osp.od.nih.gov/comment-form....
Dear SDB Members, NIH is planning to cap APC (Article Processing Charges) from grant funds for publications, starting in January 2026. https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-138.html Proposed Policy Options for Keeping Publication Costs Reasonable: Option 1: Disallow all publication costs. Option 2: Set a $2,000 limit on allowable costs per publication. Option 3: Set a $2,000 limit on allowable costs per publication and allow up to $3,000 when peer reviewers are compensated. Option 4: Set an 0.8% limit on the total amount of an award that can be spent on publication costs, up to $20,000. For example, $250,000 direct cost grant = $2,000 per year for publications. Option 5: Set a $6,000 limit on both the per publication cost and the total amount of an award (0.8% up to $20k) that can be spent on publications. The NIH is requesting comments by Sept 15. It is also possible to contribute comments that are not about any of the 5 options. Comments should be submitted electronically to the following webpage: https://osp.od.nih.gov/comment-form-maximizing-research-funds-by-limiting-allowable-publishing-costs/. Responses are voluntary and may be submitted anonymously. The SDB encourages you to submit your opinions on this important issue. Best, Richard Behringer President, SDB
August 11, 2025 at 11:30 PM
Reposted by Paul A. Welling, MD
edgarvlermamd.bsky.social
Urine sodium (Urine Na) levels post-saline infusion in differentiating non-edematous hyponatremia ca. 2025
#Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/40775013/
August 10, 2025 at 6:45 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
Coming up at APS:

• NCAR Lifetime Achievement Lecture: The Extended Autonomic System 9/4
• W/ @aurorascientific.bsky.social: Redox Regulation of Skeletal Muscle 9/9
• W/ @scireq.bsky.social: Critical Role of Pericytes in Pulmonary Circulation 9/16

Learn more: ow.ly/WEWs50WuRYU 🧪
Webinar written in date book next to coffee mug and tablet
August 11, 2025 at 1:00 PM
Reposted by Paul A. Welling, MD
jowolff.bsky.social
I don’t know why people are so confused by the idea of 1500% price decrease. If a drug originally cost $100 you’ll now get in free in a packet also containing $1400. Even I would vote for that.
August 4, 2025 at 7:10 AM
Reposted by Paul A. Welling, MD
atrupar.com
Larry Summers: "This is way beyond anything Nixon ever did ... this is the stuff of democracies giving way to authoritarianism. Firing statisticians goes with threatening the heads of newspapers, launching assaults on universities, launching assaults on law firms. This is really scary stuff."
August 3, 2025 at 3:16 PM