Paul A. Welling, MD
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pawellingmd.bsky.social
Paul A. Welling, MD
@pawellingmd.bsky.social
1.2K followers 570 following 59 posts
MD-Scientist Professor, Physiologist exploring molecular mechanisms of sodium-potassium balance, hypertension & kidney disease. Hobbies: Travel, Golf, Food, Wine & Spirits, Biking, O's fan

Johns Hopkins School of Medicine
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pawellingmd.bsky.social
Paul A. Welling, MD @pawellingmd.bsky.social · Dec 31
The Aldosterone Paradox: A Skeetutorial:
a man stands in front of a blackboard with the words it 's paradoxical and yet it works
ALT: a man stands in front of a blackboard with the words it 's paradoxical and yet it works
media.tenor.com
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
ICYMI, last week we launched "Physiology: The Science Life Depends On," a campaign to champion the discipline and protect the science behind every breakthrough. Our goal: to reintroduce physiology to the world. Learn more and join the #FightForPhysiology: fightforphysiology.org 🧪
Portrait of an elderly person outdoors with text promoting progress in physiology science. The text reads The Science Life Depends On. Let's drive physiology forward.
November 10, 2025 at 2:01 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
Today, APS is launching Physiology: The Science Life Depends On, a campaign to champion #physiology and protect the science behind every breakthrough. It's time to reintroduce physiology to the world, together. Join the #FightForPhysiology at fightforphysiology.org 🧪
A young child with brown hair looks off to the side with a thoughtful expression against a soft gray background. Above her, bold text reads: “The science life depends on. Let’s drive physiology forward.” The word “life” is written in colorful script, and “physiology” is underlined in pink.
November 6, 2025 at 3:30 PM
Reposted by Paul A. Welling, MD
hswapnil.medsky.social
Is it not really TGF - and something else in the tubules?

Fascinating Biomarker study in @ajkd.bsky.social from the EMPA-KIDNEY group

www.ajkd.org/article/S027...

cc @pranavgarimella.bsky.social

#NephSky #RevengeOfTheTubules
Figure 1 Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.
October 31, 2025 at 10:36 PM
Reposted by Paul A. Welling, MD
asnpublications.bsky.social
This #ASNCJASN original research identified ten plasma proteins associated with dietary potassium and CKD risk in a US adult population, highlighting mechanisms involving iron deposition, mitochondrial function, inflammation, and fibrosis. Read more: kidney.pub/CJASN0864

@pawellingmd.bsky.social
October 28, 2025 at 6:00 PM
Reposted by Paul A. Welling, MD
asnpublications.bsky.social
A randomized controlled trial in #ASNJASN finds that adjuvant thiazide improved diuretic response more than loop dose increased in patients with acute heart failure and diuretic resistance. Read more: kidney.pub/JASN0887

@pawellingmd.bsky.social

October 16, 2025 at 7:00 PM
Reposted by Paul A. Welling, MD
nejm.org
BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ
A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.
October 15, 2025 at 7:02 PM
Reposted by Paul A. Welling, MD
nejm.org
In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 across the overall cohort and in various subgroups. Full study results: nej.md/47anKdz

#MedSky #IDSky
A graph showing the Covid-19–associated composite outcome over 180 days in the 2024–2025 vaccination season
October 8, 2025 at 9:10 PM
Reposted by Paul A. Welling, MD
hswapnil.medsky.social
The unregulated and unscrupulous medical hydration spa industry

www.medscape.com/viewarticle/... with @fperrywilson.bsky.social
What ‘Secret Shoppers’ Discovered About IV Hydration Spas
Researchers posed as potential clients to examine the practices and regulation of the burgeoning intravenous hydration spa industry.
www.medscape.com
October 7, 2025 at 12:53 AM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
It's time! The #APS2026 abstract portal is open! Submit your best work through 12/3 and we'll see you in Minneapolis in April: https://ow.ly/EjFJ50X4p89 #WeArePhysiology 🧪
Logo for the American Physiology Summit with event dates April 23-26, 2026, held in Minneapolis.
October 1, 2025 at 1:01 PM
Reposted by Paul A. Welling, MD
vscooper.micropopbio.org
Our Pitt Microbiology and Molecular Genetics department in the School of Medicine is recruiting..

Microbiologists! 🧫🦠🔬🧪

Please apply to join our faculty and enjoy these views 👀 while doing great science

cfopitt.taleo.net/careersectio...
August 21, 2025 at 3:19 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
#BornThis Day in 1896, Gerty Cori was the first American woman to receive the 1947 #NobelPrize in #Physiology or Medicine (with scientist-husband Carl). Their work: How the body metabolizes sugar. More from @jwaonline.bsky.social: ow.ly/7YBR50WFiWz #ISpyPhysiology 🧪
A woman in a lab coat holds up a test tube for examination while a man in a lab coat stands beside her. They are surrounded by glassware, beakers, and scientific equipment in a laboratory setting.
August 15, 2025 at 7:00 PM
pawellingmd.bsky.social
The George M. O’Brien Kidney Resource Alliance announces its 3rd Opportunity Pool Program, supporting pilot grants (up to a maximum of $50,000 total costs) that address scientific and technological gaps in kidney research and promote new collaborations. www.uab.edu/okra/funding...
OKRA Opportunity Pool Program - George M. O’Brien Kidney Resource Alliance
www.uab.edu
August 14, 2025 at 4:15 PM
Reposted by Paul A. Welling, MD
peiferlabunc.bsky.social
NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at:
osp.od.nih.gov/comment-form....
Dear SDB Members, NIH is planning to cap APC (Article Processing Charges) from grant funds for publications, starting in January 2026. https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-138.html Proposed Policy Options for Keeping Publication Costs Reasonable: Option 1: Disallow all publication costs. Option 2: Set a $2,000 limit on allowable costs per publication. Option 3: Set a $2,000 limit on allowable costs per publication and allow up to $3,000 when peer reviewers are compensated. Option 4: Set an 0.8% limit on the total amount of an award that can be spent on publication costs, up to $20,000. For example, $250,000 direct cost grant = $2,000 per year for publications. Option 5: Set a $6,000 limit on both the per publication cost and the total amount of an award (0.8% up to $20k) that can be spent on publications. The NIH is requesting comments by Sept 15. It is also possible to contribute comments that are not about any of the 5 options. Comments should be submitted electronically to the following webpage: https://osp.od.nih.gov/comment-form-maximizing-research-funds-by-limiting-allowable-publishing-costs/. Responses are voluntary and may be submitted anonymously. The SDB encourages you to submit your opinions on this important issue. Best, Richard Behringer President, SDB
August 11, 2025 at 11:30 PM
Reposted by Paul A. Welling, MD
edgarvlermamd.bsky.social
Urine sodium (Urine Na) levels post-saline infusion in differentiating non-edematous hyponatremia ca. 2025
#Nephpearls #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/40775013/
August 10, 2025 at 6:45 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
Coming up at APS:

• NCAR Lifetime Achievement Lecture: The Extended Autonomic System 9/4
• W/ @aurorascientific.bsky.social: Redox Regulation of Skeletal Muscle 9/9
• W/ @scireq.bsky.social: Critical Role of Pericytes in Pulmonary Circulation 9/16

Learn more: ow.ly/WEWs50WuRYU 🧪
Webinar written in date book next to coffee mug and tablet
August 11, 2025 at 1:00 PM
Reposted by Paul A. Welling, MD
jowolff.bsky.social
I don’t know why people are so confused by the idea of 1500% price decrease. If a drug originally cost $100 you’ll now get in free in a packet also containing $1400. Even I would vote for that.
August 4, 2025 at 7:10 AM
Reposted by Paul A. Welling, MD
atrupar.com
Larry Summers: "This is way beyond anything Nixon ever did ... this is the stuff of democracies giving way to authoritarianism. Firing statisticians goes with threatening the heads of newspapers, launching assaults on universities, launching assaults on law firms. This is really scary stuff."
August 3, 2025 at 3:16 PM
Reposted by Paul A. Welling, MD
statnews.com
Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com/2025/08/04/b...
Gates Foundation pledges $2.5 billion to women’s health initiatives
Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com
August 4, 2025 at 2:09 PM
Reposted by Paul A. Welling, MD
atrupar.com
TAPPER: 14 Republicans say you're risking undermining critical research by holding up NIH funding

VOUGHT: If they were a company, their stock price would in shambles. They in some respects caused the pandemic. You have an entire institute that does nothing more than DEI research at the NIH.
July 27, 2025 at 1:37 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
"We assert that these cuts and restructuring plans, developed without Congressional or stakeholder expertise, will essentially dismantle NIH as we know it."

APS and 100+ more associations urge Congress: Exercise oversight for National Institutes of Health: ow.ly/mMpe50WmmnA #advocacy 🧪
National Institutes of Health building against a blue sky.
July 16, 2025 at 1:00 PM
Reposted by Paul A. Welling, MD
drkwilkinson.bsky.social
Find some great language for your comment about the need for community input, need for rigorous validation of NAMs & importance of animal research at @faseborg.bsky.social ‘s statement : www.faseb.org/getmedia/9ee... 🧪
July 12, 2025 at 3:09 AM
Reposted by Paul A. Welling, MD
thebalelab.bsky.social
The House Appropriations Subcommittee for HHS markup is scheduled for July 21 and full comm July 24. Not much time. Make those calls ☎️ to your congressional leaders NOW 🚨! Make sure they hear the devastation that will happen to research 🔬, training 👩🏽‍🔬 and health 🩺 if the proposed cuts go forward.
July 3, 2025 at 5:55 PM
Reposted by Paul A. Welling, MD
apspublications.bsky.social
📢TIME IS RUNNING OUT! Submissions for the Physiology Essay Contest are due by Tuesday, July 15.

✍️What big open question in the field of physiology are you most excited about and why?

Submit today! ow.ly/KR7X50VR4e6
July 1, 2025 at 7:00 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
READ: From @forbes.com, "How To Stay Focused At Work When Everything Feels Uncertain": ow.ly/N0cX50WgNZn #ProfDev 🧪
A woman sits at a desk with a laptop and coffee cup, gazing thoughtfully out a window with a distant expression.
July 1, 2025 at 1:00 PM
Reposted by Paul A. Welling, MD
apsphysiology.bsky.social
If you're concerned about #biomedical research funding, it's time to raise your voice and take action. Sign up for APS Action Alerts to help elevate the collective voice and impact of the #physiology community: ow.ly/7gIr50WfGmX #SciPol #advocacy #FundScience 🧪
A photo of the U,S, Capitol building.
June 25, 2025 at 1:00 PM