Paul Sheppard 🧠
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paulsheppard.bsky.social
Paul Sheppard 🧠
@paulsheppard.bsky.social
Behavioural neuroscience, poems, running, weird noises — ALLERGIC TO FUN
Reposted by Paul Sheppard 🧠
Don't miss @paulsheppard.bsky.social's visually innovative poem "a n y w a y (s)" in Issue 32! Excerpting doesn't do it justice; just click through to the poem:

www.thetemzreview.com/sheppard-32....
September 16, 2025 at 3:12 AM
Reposted by Paul Sheppard 🧠
September 10, 2025 at 8:00 PM
It's tragic, but I forgot to post this Good Meme when the touchscreen cognitive judgement bias paper came out.
(paper link for context: www.nature.com/articles/s41...)
July 16, 2025 at 2:53 PM
I ran my first ultra distance race today, an intense and technical 56km @limberlosttrailrun.bsky.social . It was HOT and I learned a lot of things that I'll do differently next time, but it was some great Type 2 Fun!
July 6, 2025 at 1:04 AM
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July 1, 2025 at 7:00 AM
Today I ran just shy of a marathon during a race called The Farthest put on by Persistence Racing. Everyone started from the same point and ran in whatever direction they wanted to get the farthest as the crow flies within 2, 4, or 8h. I did the 4h "Half-Farthest".
June 21, 2025 at 8:12 PM
From canceled faculty hiring searches to this in <6 months... 👀
Simon Fraser University invites applications from world-renowned researchers for the Canada Excellence Research Chairs (CERC) 2026 competition, offering up to $8M over eight years to support innovative and impactful research. Learn more and apply by June 30: www.sfu.ca/vpacademic/a...
Canada Excellence Research Chairs (CERC) 2026 Competition
www.sfu.ca
June 6, 2025 at 10:32 PM
In case you were wondering (you 100% weren't): the mouse in the graphical abstract is "greyer mouse" because "grey mouse" just wasn't grey enough for certain co-authors who will go unnamed...
June 4, 2025 at 3:28 PM
Reposted by Paul Sheppard 🧠
Happy to share the current version of our latest story, currently under peer review. Cool collab with @dablab.bsky.social @manickam-lab.bsky.social and others. We are not only understanding endothelial deficits in an #autism model, but now also capable of rescuing them! #16p11.2 #treatment #P2Y2
Purinergic receptor activation rectifies autism-associated endothelial dysfunction
Early cerebrovascular alterations affect brain maturation by impacting trophic support and energy supply. Recent evidence in a 16p11.2 deletion mouse model of autism spectrum disorder (ASD) revealed b...
www.biorxiv.org
June 3, 2025 at 8:33 AM
🚨 NEW PAPER ALERT 🚨
🚨 KLAXON KLAXON 🚨

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy

onlinelibrary.wiley.com/doi/10.1111/...
Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy
The amyloid precursor protein knock-in mouse model of amyloidopathy (AppNL-G-F/NL-G-F) was assessed on touchscreen-based learning and cognitive flexibility tasks in comparison with both AppNL/NL and ....
onlinelibrary.wiley.com
June 2, 2025 at 5:38 PM
Reposted by Paul Sheppard 🧠
Well done to all of our affiliated presenters at this year's @canacn.bsky.social Meeting! Great work!
May 27, 2025 at 3:58 PM
Reposted by Paul Sheppard 🧠
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
Norepinephrine signals through astrocytes to modulate synapses
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...
www.science.org
May 16, 2025 at 4:34 AM
Reposted by Paul Sheppard 🧠
Dr. Adebiyi kicking off our second session with an exciting talk about demyelination and repair! #KeepSmyelin
May 20, 2025 at 7:28 PM
Reposted by Paul Sheppard 🧠
We are back for our 2nd CANGlia meeting in beautiful Toronto for a day of exciting Glial science! #CANGlia2025
May 20, 2025 at 1:24 PM
Reposted by Paul Sheppard 🧠
Come and work with the Translational Cognitive Neuroscience Lab! We are looking for a #labmanager who wants to understand the circuits and mechanisms underlying cognition. Search ID 39142 at: recruit.uwo.ca
May 15, 2025 at 4:08 PM
Reposted by Paul Sheppard 🧠
May 16, 2025 at 1:00 AM
Reposted by Paul Sheppard 🧠
Very nice series of papers showing the effects of noradrenaline on brain circuits and behaviour require astrocytes. Congrats to the three labs on this fantastic work!

www.science.org/doi/10.1126/...
Astrocytes, hidden puppet masters of the brain
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
www.science.org
May 15, 2025 at 8:27 PM
FINALLY a mnemonic that is legitimately helpful for this!
The difference between a tornado WATCH and a tornado WARNING is that a WARNING means it's imminent 🚨 but if it's a WATCH you've got time ⌚

(yes I've seen the taco/sandwich/whatever memes but this is the only one I can remember because it has the watch-time word association)
May 15, 2025 at 9:35 PM
My poem "I Fix the Door Open with My Bones" appears in the premiere issue of Diceroll.

Go show them some love!

diceroll.press
diceroll press
diceroll.press
May 10, 2025 at 4:24 PM
Many thanks to The Trinity Review for publishing my poem "Before the Grassfires Flew" in issue 137.1.

You can check it, and others, out here: www.thetrinityreview.com/download
May 8, 2025 at 11:56 AM
Today I ran my first marathon ❤️
May 4, 2025 at 8:01 PM
Stayed up late last night to register for my fall goal race! Running the 50km at The Bad Thing trail race 🤘🏻
May 1, 2025 at 12:30 PM
Reposted by Paul Sheppard 🧠
April 27, 2025 at 2:00 AM