Yeehaw!

It was hot, humid, then rainy; it was a lot. I wanted to go farther in the 4h but it wasn't in the cards today. But what a fun concept and a fun race!

It must be really frustrating for those who were on search committees that had their searches cancelled to see this. It's a lot of work!

So check it out! And many thanks to the whole crew that worked on this! @westernubrainscan.bsky.social @timbussey.bsky.social @lisasaksida.bsky.social @maximoprado.bsky.social @touchscreencog.bsky.social @tcnlab.bsky.social

We also present some interesting data regarding a knock-in model often used as a control for this amyloidopathy model since they do not develop plaques. We found that despite this lack of plaque development, they show more profound decreases in cognitive flexibility across age compared to wildtypes.

We show herein that a mouse model of aggressive amyloidopathy can learn to discriminate visual cues, but, following learning, are deficit in reversing what they've learned (cognitive flexibility) and show perseverative responding.

Amazing work as always, Lewis!