Parker Singleton
@parkersingleton.bsky.social
Senior Scientist at Penn Lifespan Informatics and Neuroimaging Center (PennLINC) studying psychedelics and the brain.
sypres.io
sypres.io
Pinned
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Parker Singleton
Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA
10.1093/brain/awaf391
10.1093/brain/awaf391
October 27, 2025 at 3:33 AM
Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA
10.1093/brain/awaf391
10.1093/brain/awaf391
Hot off the press!
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 7:42 PM
Hot off the press!
Reposted by Parker Singleton
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
nature.com
October 15, 2025 at 8:18 PM
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
👇🧵
nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging
If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.
October 14, 2025 at 3:32 PM
If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.
Reposted by Parker Singleton
I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.
October 6, 2025 at 10:00 PM
I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.
Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
Funded by National Institute of Mental Health (NIMH)
September 24, 2025 at 12:58 PM
Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.
Reposted by Parker Singleton
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
September 7, 2025 at 2:59 PM
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
I'm near certain sLFOs are big for psychedelics.
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
www.medrxiv.org
August 26, 2025 at 5:14 PM
I'm near certain sLFOs are big for psychedelics.
Reposted by Parker Singleton
Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊
August 15, 2025 at 9:08 AM
Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity
We investigate the spatiotemporal organization of resting-state brain activity in individuals with and without major depressive disorder (MDD), identifying stable and recurring whole-brain functional ...
www.researchsquare.com
August 21, 2025 at 1:26 PM
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Reposted by Parker Singleton
✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky
#neuroskyence #devpsych #PsychSciSky
Timing and plasticity are critical to progress in research on stress and neurodevelopment
@ariellekeller.bsky.social
@jamapediatrics.com
@utdallas.bsky.social
jamanetwork.com/journals/jam...
@ariellekeller.bsky.social
@jamapediatrics.com
@utdallas.bsky.social
jamanetwork.com/journals/jam...
Neurodevelopmental Timing Links Stress and Psychopathology
This Viewpoint discusses the importance of contextualizing stressful experiences and the neurodevelopmental trajectory to predict the risk of psychopathology.
jamanetwork.com
August 19, 2025 at 5:56 PM
✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky
#neuroskyence #devpsych #PsychSciSky
Reposted by Parker Singleton
Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
On the left is a rabbit. On the right is an elephant. But guess what: They’re the *same image*, rotated 90°!
In @currentbiology.bsky.social, @chazfirestone.bsky.social & I show how these images—known as “visual anagrams”—can help solve a longstanding problem in cognitive science. bit.ly/45BVnCZ
In @currentbiology.bsky.social, @chazfirestone.bsky.social & I show how these images—known as “visual anagrams”—can help solve a longstanding problem in cognitive science. bit.ly/45BVnCZ
August 19, 2025 at 4:51 PM
Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
“No!”, you say.
Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social
🐇🐘
Reposted by Parker Singleton
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 2:37 PM
Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 1:17 PM
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
@audreycluo.bsky.social has had one of the most impressive graduate careers I've ever seen. Kudos!!!!
CONGRATS TO DOCTOR @audreycluo.bsky.social !!! Last week, Dr. Luo knocked our collective socks off with a thesis defense for the ages. Her presentation on "Axes of Hierarchical Brain Development" was magnificent -- beautiful science, presented in an incredibly accessible and engaging way. WOO!!!!
August 14, 2025 at 10:47 PM
@audreycluo.bsky.social has had one of the most impressive graduate careers I've ever seen. Kudos!!!!
Reposted by Parker Singleton
Somehow we got almost all the students and postdocs in one photo!!
Until next time #GRCPsychedelics 🫡
Until next time #GRCPsychedelics 🫡
July 18, 2025 at 6:51 PM
Somehow we got almost all the students and postdocs in one photo!!
Until next time #GRCPsychedelics 🫡
Until next time #GRCPsychedelics 🫡
Reposted by Parker Singleton
So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!
July 18, 2025 at 8:33 PM
So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!
Reposted by Parker Singleton
Great panel this morning on the human and clinical studies of psychedelics -
my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
July 17, 2025 at 4:20 PM
Great panel this morning on the human and clinical studies of psychedelics -
my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics
Reposted by Parker Singleton
#GRCPsychedelics 🔥🔥🔥🔥poster session and our first ever Honorary Best PI poster award to @zenbrainest.bsky.social 🤣🤣🤣
July 15, 2025 at 9:51 PM
#GRCPsychedelics 🔥🔥🔥🔥poster session and our first ever Honorary Best PI poster award to @zenbrainest.bsky.social 🤣🤣🤣
Reposted by Parker Singleton
Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
July 16, 2025 at 11:37 PM
Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
Reposted by Parker Singleton
Good morning! An excellent panel today on the evolving theory for explaining psychedelic drug action #GRCPsychedelics
July 14, 2025 at 4:34 PM
Good morning! An excellent panel today on the evolving theory for explaining psychedelic drug action #GRCPsychedelics
Reposted by Parker Singleton
We systematically reviewed 23 in vitro and 26 in vivo electrophysiological studies on psychedelic compounds, with an emphasis on layer 5 pyramidal neurons.
Our results challenge the simplified view that psychedelics uniformly increase cortical excitability
www.biorxiv.org/content/10.1...
Our results challenge the simplified view that psychedelics uniformly increase cortical excitability
www.biorxiv.org/content/10.1...
July 11, 2025 at 12:00 PM
We systematically reviewed 23 in vitro and 26 in vivo electrophysiological studies on psychedelic compounds, with an emphasis on layer 5 pyramidal neurons.
Our results challenge the simplified view that psychedelics uniformly increase cortical excitability
www.biorxiv.org/content/10.1...
Our results challenge the simplified view that psychedelics uniformly increase cortical excitability
www.biorxiv.org/content/10.1...
Amazing work by @valeriejsydnor.bsky.social !!!!
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
July 9, 2025 at 12:16 PM
Amazing work by @valeriejsydnor.bsky.social !!!!
yea, that random structure with a hypervalent nitrogen is definitely 5-meo-dmt
July 3, 2025 at 1:04 PM
yea, that random structure with a hypervalent nitrogen is definitely 5-meo-dmt
I'm both glad and jealous to see that it looks like @ohbmofficial.bsky.social booked a proper club dj this year. #FOMO
June 27, 2025 at 4:24 PM
I'm both glad and jealous to see that it looks like @ohbmofficial.bsky.social booked a proper club dj this year. #FOMO