Cole Korponay
@ckorponay.bsky.social
🧠 Instructor in Psychiatry
@ Harvard Medical School | McLean Hospital
| Trying to squeeze better brain juice from fMRI
@ Harvard Medical School | McLean Hospital
| Trying to squeeze better brain juice from fMRI
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Systemic physiological "noise" in fMRI has clinical relevance
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...
www.medrxiv.org
August 26, 2025 at 4:44 PM
An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
Extracting the sLFO signal from BOLD data not only sharpens FC estimates..
..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging
How do we focus on the task in front of us amidst emotionally salient distractors?
Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals
www.nature.com/articles/s42...
#neuroimaging #neuroskyence #compneurosky
Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals
www.nature.com/articles/s42...
#neuroimaging #neuroskyence #compneurosky
Disentangling large-scale brain dynamics and their links to behavior during the emotional face matching task - Communications Biology
Tensor independent component analysis reveals the concurrent brain processes at work during emotion interference suppression and how individual differences relate to cognitive fitness.
www.nature.com
August 13, 2025 at 11:11 AM
How do we focus on the task in front of us amidst emotionally salient distractors?
Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals
www.nature.com/articles/s42...
#neuroimaging #neuroskyence #compneurosky
Our new paper details the numerous cogs churning simultaneously in the brain to stave off "emotion interference" and focus on task goals
www.nature.com/articles/s42...
#neuroimaging #neuroskyence #compneurosky
#MentalHealth status is written somewhere in #Brain activity
But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible
Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵
biorxiv.org/content/10.1...
But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible
Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵
biorxiv.org/content/10.1...
July 10, 2025 at 7:05 PM
#MentalHealth status is written somewhere in #Brain activity
But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible
Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵
biorxiv.org/content/10.1...
But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible
Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵
biorxiv.org/content/10.1...
Hey friends, Wed at 9:30a ET I'll be giving a public talk on our recent work (tinyurl.com/3jatmf9e) + what's next..
"Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers"
Tune in here! us06web.zoom.us/j/8805219099...
(Meeting ID 880 5219 0990; Passcode 673919)
"Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers"
Tune in here! us06web.zoom.us/j/8805219099...
(Meeting ID 880 5219 0990; Passcode 673919)
April 7, 2025 at 2:12 PM
Hey friends, Wed at 9:30a ET I'll be giving a public talk on our recent work (tinyurl.com/3jatmf9e) + what's next..
"Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers"
Tune in here! us06web.zoom.us/j/8805219099...
(Meeting ID 880 5219 0990; Passcode 673919)
"Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers"
Tune in here! us06web.zoom.us/j/8805219099...
(Meeting ID 880 5219 0990; Passcode 673919)
Reposted by Cole Korponay
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine - Neuropsychopharmacology
Neuropsychopharmacology - Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine
www.nature.com
March 13, 2025 at 7:10 PM
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
Reposted by Cole Korponay
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns https://www.biorxiv.org/content/10.1101/2024.12.26.628516v1
December 27, 2024 at 7:16 AM
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns https://www.biorxiv.org/content/10.1101/2024.12.26.628516v1
How do little ol' 💊s come to perturb big ol' 🧠 networks?
In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key:
onlinelibrary.wiley.com/doi/full/10....
Also, hello #Neuro Bluesky!
In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key:
onlinelibrary.wiley.com/doi/full/10....
Also, hello #Neuro Bluesky!
Catecholaminergic Modulation of Large‐Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity
At rest, the dopamine/norepinephrine agonist, methylphenidate, enhances time spent in external and internal attentional neurobiological states (DAN and DMN, respectively), suggesting the brain is pri...
onlinelibrary.wiley.com
December 18, 2024 at 8:18 PM
How do little ol' 💊s come to perturb big ol' 🧠 networks?
In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key:
onlinelibrary.wiley.com/doi/full/10....
Also, hello #Neuro Bluesky!
In new work led by Justine Hill, we show that small but widespread effects on individual connections, which in aggregate can reconfigure regional input profiles, are key:
onlinelibrary.wiley.com/doi/full/10....
Also, hello #Neuro Bluesky!