What's the take-away?

Measurements of non-cognitive mental health and measurements of brain function during common fMRI tasks have little to do with one another

Akin to cardiac stress tests, more affectively provocative tasks may be needed to evoke🧠activity w/ MH relevance

We also found that:

1) Brain data and mental health data sorted subjects into discordant sets of subtypes

2) Subjects' relatively similar evoked brain activity profiles failed to reflect the comparatively diverse set of mental health profiles across subjects

Multi-network based prediction was also only successful for cognition and proc speed.

Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.

Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content.

Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.

In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance

(We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...

#MentalHealth status is written somewhere in #Brain activity

But even in today’s most marvelously modeled, spotlessly cleaned🧠data, the writing is barely legible

Why? Perhaps,🧠activity evoked by typical🧠scanning conditions just has little MH info🧵

biorxiv.org/content/10.1...

Multi-network based prediction was also only successful for cognition and proc speed.

Importantly, the composite scores used for each MH domain all had high measurement reliability and similar interindividual variability.

Across all 77 networks, none robustly or reproducibly encoded #WellBeing, #Internalizing or #SubstanceUse, even during tasks w/ socioemotional content.

Instead,🧠network activity near-exclusively encoded individual differences in #cognition across all paradigms.

In our new paper, we searched for markers of normative MH variability in all the evoked🧠networks we could find across a slew of fMRI paradigms w/ putative MH relevance

(We've released maps of all 77 networks in a new "Task-Evoked Network Atlas"): identifiers.org/neurovault.c...

E.g.:

www.nature.com/articles/s41...

Hey friends, Wed at 9:30a ET I'll be giving a public talk on our recent work (tinyurl.com/3jatmf9e) + what's next..

"Inflating brain connections: how blood, arousal and the brain conspired to fool 🧠imagers"

Tune in here! us06web.zoom.us/j/8805219099...
(Meeting ID 880 5219 0990; Passcode 673919)