Oliver Stegle
@oliverstegle.bsky.social
Scientist at DKFZ and EMBL in Heidelberg, loving stats, genomics and genetics. @OliverStegle@genomic.social. For group news see @steglelab.bluesky.social
I'm impressed by how far this model class has taken us—MOFA-FLEX may be the final iteration—a framework geared more towards generating models than being a standalone model itself. User-friendly, probabilistic programming rocks! We look forward to your feedback and experiences trying it out!
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
November 8, 2025 at 9:06 PM
I'm impressed by how far this model class has taken us—MOFA-FLEX may be the final iteration—a framework geared more towards generating models than being a standalone model itself. User-friendly, probabilistic programming rocks! We look forward to your feedback and experiences trying it out!
Reposted by Oliver Stegle
Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader – AI in Biology
Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...
embl.wd103.myworkdayjobs.com
September 8, 2025 at 11:43 AM
Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Oliver Stegle
If you want more information please contact @oliverstegle.bsky.social who is leading AI @ EMBL and please do forward this thread / websites to anyone who you think might be interested.
September 8, 2025 at 11:43 AM
If you want more information please contact @oliverstegle.bsky.social who is leading AI @ EMBL and please do forward this thread / websites to anyone who you think might be interested.
You are passionate about making data accessible? The Heidelberg Mannheim life science builds a data space - a major step for bridging basic science and translation. Two of more jobs to come. Technical lead and cloud engineer jobs.dkfz.de/en/jobs/1680... jobs.dkfz.de/en/jobs/1680...
Technical Lead for the "Health + Life Science Alliance Data Space"
jobs.dkfz.de
August 28, 2025 at 9:06 AM
You are passionate about making data accessible? The Heidelberg Mannheim life science builds a data space - a major step for bridging basic science and translation. Two of more jobs to come. Technical lead and cloud engineer jobs.dkfz.de/en/jobs/1680... jobs.dkfz.de/en/jobs/1680...
Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share!
embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
Postdoctoral Researcher in Computational Genetics
The research group of Oliver Stegle looks for a postdoctoral researcher to join a collaborative project with GSK with the goal to apply computational methods to investigate the effects of rare variant...
embl.wd103.myworkdayjobs.com
June 26, 2025 at 10:00 AM
Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share!
embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
embl.wd103.myworkdayjobs.com/de-DE/EMBL/d...
Reposted by Oliver Stegle
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
May 19, 2025 at 1:23 PM
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
Super happy and proud of this one. We and others have developed tools for dimensionality reduction for many years. MOFA (linear) and other non-linear generalisations, space/time. scDORI fuses this with GRN inference. It’s a nice and useful piece of software. Here applied to GBM biology.
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
May 19, 2025 at 3:38 PM
Super happy and proud of this one. We and others have developed tools for dimensionality reduction for many years. MOFA (linear) and other non-linear generalisations, space/time. scDORI fuses this with GRN inference. It’s a nice and useful piece of software. Here applied to GBM biology.
Happy birthday! What a trajectory in just 3y. More exciting tools & packages and of course community.
scverse turns 3!
What started as a shared vision for interoperable single-cell analysis has become a vibrant, global community.
From AnnData to full multimodal pipelines, we’re building the future of everything single-cell and spatial omics, together.
Here’s to what’s next!
What started as a shared vision for interoperable single-cell analysis has become a vibrant, global community.
From AnnData to full multimodal pipelines, we’re building the future of everything single-cell and spatial omics, together.
Here’s to what’s next!
May 19, 2025 at 3:35 PM
Happy birthday! What a trajectory in just 3y. More exciting tools & packages and of course community.
Reposted by Oliver Stegle
May 18, 2025 at 2:37 PM
Reposted by Oliver Stegle
The next #ScienceatDKFZ event will take place on Monday, 12 May 2025, at 4 pm. In addition to the keynote lecture by Christoph Plass, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...
➡️ dkfz.de/en/news/even...
May 7, 2025 at 8:22 AM
The next #ScienceatDKFZ event will take place on Monday, 12 May 2025, at 4 pm. In addition to the keynote lecture by Christoph Plass, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications.
➡️ dkfz.de/en/news/even...
➡️ dkfz.de/en/news/even...
Reposted by Oliver Stegle
Our unit is connecting @dkfz.bsky.social, @uniheidelberg.bsky.social & @embl.org -
@oliverstegle.bsky.social, @lena-maier-hein.bsky.social, @wkhuber.bsky.social, @brittavelten.bsky.social,
Anna Kreshuk, Carsten Rother, Fred Hamprecht, Jan Korbel, Ullrich Köthe, Klaus Maier-Hein, Tilman Plehn, ...
@oliverstegle.bsky.social, @lena-maier-hein.bsky.social, @wkhuber.bsky.social, @brittavelten.bsky.social,
Anna Kreshuk, Carsten Rother, Fred Hamprecht, Jan Korbel, Ullrich Köthe, Klaus Maier-Hein, Tilman Plehn, ...
April 30, 2025 at 7:51 AM
Our unit is connecting @dkfz.bsky.social, @uniheidelberg.bsky.social & @embl.org -
@oliverstegle.bsky.social, @lena-maier-hein.bsky.social, @wkhuber.bsky.social, @brittavelten.bsky.social,
Anna Kreshuk, Carsten Rother, Fred Hamprecht, Jan Korbel, Ullrich Köthe, Klaus Maier-Hein, Tilman Plehn, ...
@oliverstegle.bsky.social, @lena-maier-hein.bsky.social, @wkhuber.bsky.social, @brittavelten.bsky.social,
Anna Kreshuk, Carsten Rother, Fred Hamprecht, Jan Korbel, Ullrich Köthe, Klaus Maier-Hein, Tilman Plehn, ...
Start your own group at DKFZ! jobs.dkfz.de/en/jobs/1677...
Head of an independent Junior Research Group with Tenure Option at the German Cancer Research Center (DKFZ)
jobs.dkfz.de
May 7, 2025 at 8:55 AM
Start your own group at DKFZ! jobs.dkfz.de/en/jobs/1677...
Reposted by Oliver Stegle
“We all rely on science.” U.S. scientists are speaking out for scientific integrity and academic freedom. What they’re doing matters. We owe them our solidarity and a clear stand beside them.
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
Trump Administration Has Begun a War on Science, Researchers Say (Gift Article)
Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.
www.nytimes.com
March 31, 2025 at 10:39 PM
“We all rely on science.” U.S. scientists are speaking out for scientific integrity and academic freedom. What they’re doing matters. We owe them our solidarity and a clear stand beside them.
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
Reverse brain drain? But yes, science in Europe is great!
Judging by the new round of PhD student applicants to @embl.org the brain drain has started. DM me if you have questions about moving to Europe.
March 27, 2025 at 12:45 PM
Reverse brain drain? But yes, science in Europe is great!
Reposted by Oliver Stegle
Are you a young researcher and want to access state-of-the-art technology? The Corporate Partnership Programme is your chance! 💥
CPP cover:
💡 opportunity to build new networks
💰 short-term fellows up to 4.000€
🌍 eligible to stay at EMBL sites
Apply until 31 March: www.embl.org/about/info/s...
CPP cover:
💡 opportunity to build new networks
💰 short-term fellows up to 4.000€
🌍 eligible to stay at EMBL sites
Apply until 31 March: www.embl.org/about/info/s...
March 26, 2025 at 8:28 AM
Are you a young researcher and want to access state-of-the-art technology? The Corporate Partnership Programme is your chance! 💥
CPP cover:
💡 opportunity to build new networks
💰 short-term fellows up to 4.000€
🌍 eligible to stay at EMBL sites
Apply until 31 March: www.embl.org/about/info/s...
CPP cover:
💡 opportunity to build new networks
💰 short-term fellows up to 4.000€
🌍 eligible to stay at EMBL sites
Apply until 31 March: www.embl.org/about/info/s...
Reposted by Oliver Stegle
Interview von Wolfgang Wick mit der Deutschen Welle zum Thema "Brain Drain" von Wissenschaflter*innen in den USA als Chance für Deutschland.
Dieses Video ist nur auf deutsch erhältlich.
youtu.be/0GtZ_lfL8Rc?...
Dieses Video ist nur auf deutsch erhältlich.
youtu.be/0GtZ_lfL8Rc?...
Wie Europa von Trumps Krieg gegen die Wissenschaft profitieren könnte | DW Nachrichten
YouTube video by DW Deutsch
youtu.be
March 26, 2025 at 9:45 AM
Interview von Wolfgang Wick mit der Deutschen Welle zum Thema "Brain Drain" von Wissenschaflter*innen in den USA als Chance für Deutschland.
Dieses Video ist nur auf deutsch erhältlich.
youtu.be/0GtZ_lfL8Rc?...
Dieses Video ist nur auf deutsch erhältlich.
youtu.be/0GtZ_lfL8Rc?...
Reposted by Oliver Stegle
Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
March 19, 2025 at 5:31 PM
Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Funding call with deadline 15 June, decisions in July.
www.embl.org/about/info/s...
Reposted by Oliver Stegle
We’re thrilled to announce that the EMBL-EBI Thornton Building has been officially opened by Lord Vallance of Balham, the UK’s Minister for Science, Research and Innovation.
We hope it will be a space where collaboration, translation, and science can thrive! 🌱
We hope it will be a space where collaboration, translation, and science can thrive! 🌱
March 19, 2025 at 5:39 PM
We’re thrilled to announce that the EMBL-EBI Thornton Building has been officially opened by Lord Vallance of Balham, the UK’s Minister for Science, Research and Innovation.
We hope it will be a space where collaboration, translation, and science can thrive! 🌱
We hope it will be a space where collaboration, translation, and science can thrive! 🌱
I could not really motivate myself to start properly on Bluesky following my departure from twitter. Maybe this picture is a good place to start. Antwerpen central station. What a building m!! Looking forward to www.vibconferences.be/events/revol...
March 19, 2025 at 12:23 PM
I could not really motivate myself to start properly on Bluesky following my departure from twitter. Maybe this picture is a good place to start. Antwerpen central station. What a building m!! Looking forward to www.vibconferences.be/events/revol...
Really great collab with @moritzgerstung.bsky.social and Dana Pe’er lab. Excited to hear what you all think. Cell segmentation is just hard… more to
Come! Will also show a bit of it tomorrow at www.vibconferences.be/events/revol....
Come! Will also show a bit of it tomorrow at www.vibconferences.be/events/revol....
March 19, 2025 at 12:21 PM
Really great collab with @moritzgerstung.bsky.social and Dana Pe’er lab. Excited to hear what you all think. Cell segmentation is just hard… more to
Come! Will also show a bit of it tomorrow at www.vibconferences.be/events/revol....
Come! Will also show a bit of it tomorrow at www.vibconferences.be/events/revol....
March 12, 2024 at 1:16 PM