I am thrilled to share that I was selected for an @embo.org Postdoctoral Fellowship. Soon, I will join the lab of @mfwhite2.bsky.social to study prokaryotic immune mechanisms. Super exciting!

🎬 Episode 12 of #SpotOnScience is out!

In this episode, Sophie Binder from the group of Gregor Hagelücken introduces her work "The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease".

Check out the episode here: www.youtube.com/watch?v=cDTs...

#science #research #immunology

It was a pleasure to present my #TRAP #transporter work at this year's #BFB annual meeting.

Nature research paper: CARD domains mediate anti-phage defence in bacterial gasdermin systems

https://go.nature.com/3CvoD3W

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria

We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase

Congrats Francois Rousset, Ilya Osterman and coauthors!

www.science.org/doi/10.1126/...

Colored nuclei reveal cellular key genes
The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a metho...
weiterlesen

*Fully funded PhD position available in the lab*

We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation.

Please share, and email for details :)

www.findaphd.com/phds/project...

Atomic structures of biological molecules have never been so available and ubiquitous, but this raises questions as to how they are made appropriately accessible for optimal use t.co/RTx2WLxR0W

Safer, nonradioactive staining alternatives for electron microscopy are introduced, simplifying sample preparation, reducing costs and making structural biology more accessible to researchers globally #NegativeStaining #ElectronMicroscopy doi.org/10.1107/S205...

The link to the github and colab notebook remains unchaged, we now however include a link to the design models and sequences which you can download here:
github.com/martinpacesa...
doi.org/10.5281/zeno...

Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!

www.sisb2025.conferences-pasteur.org/home

Joins us in Institut Pasteur, Paris, April 8-10th.

Amazing work capturing NaDC3 in multiple states and with various substrates/inhibitors!

Congrats Yan Li, Da-Neng Wang, Joe Mindell, and Bill Rice!!

www.nature.com/articles/s41...

#CASP16 results are in! Template-based VFold seems to be lead method for nucleic acid structure prediction! AlphaFold2 and 3 still seem to be best methods for protein monomer and complex prediction.

I’m very excitement to share a preprint of some very recent work from our lab on our continuing odyssey into the very interesting world of TAXI TRAP transporters.
tinyurl.com/4a7fra4x
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All cells are encapsulated by a membrane of complex lipidic composition, right?

Not anymore! @JamesSaenz.bsky.social et al. show that a ‘minimal’ bacterial cell only needs 2 lipid species

#microNatComms #Microbiology #CellBiology #lipids

Read the paper:
www.nature.com/artic...

Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays.
Way to go Jimbo!

We identified a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP.
Thanks to the team including: @philipphendricks.bsky.social @scbinder.bsky.social @gavinhthomas.bsky.social @gha14.bsky.social
Read the full story here:

doi.org/10.1038/s420...