Nikhita Kirthivasan
@nikhitak.bsky.social
Graduate Student at UCSF BMS Program @Cyster Lab
Undergrad @IISc
Immuno Enthusiast
Undergrad @IISc
Immuno Enthusiast
Reposted by Nikhita Kirthivasan
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
November 14, 2025 at 3:29 AM
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
Reposted by Nikhita Kirthivasan
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 5:45 PM
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
Reposted by Nikhita Kirthivasan
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
November 10, 2025 at 5:01 PM
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
Reposted by Nikhita Kirthivasan
Brain fibroblasts are dynamic regulators of tissue repair and immunomodulation after injury, with implications for understanding scar formation, function and long-term outcomes of acute brain injuries @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 21, 2025 at 1:50 AM
Brain fibroblasts are dynamic regulators of tissue repair and immunomodulation after injury, with implications for understanding scar formation, function and long-term outcomes of acute brain injuries @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nikhita Kirthivasan
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature
Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
www.nature.com
October 15, 2025 at 3:52 PM
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Reposted by Nikhita Kirthivasan
1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature
Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local im...
www.nature.com
September 3, 2025 at 4:43 PM
1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congrats to the amazing Dr Arce!
Welcome to our third Science Fellow, Maya Arce (@mayaarce.bsky.social). Her team uses large-scale genomic screening and CRISPR editing to decode how genetic regulators control immune cell behavior.
September 4, 2025 at 6:24 AM
Congrats to the amazing Dr Arce!
Reposted by Nikhita Kirthivasan
Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
May 16, 2025 at 6:11 PM
Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
Reposted by Nikhita Kirthivasan
#WeekendRead! #ImmunoglobulinPower! Jabri &co show @cp-cellhostmicrobe.bsky.social that intestinal IgAs prevent chronic colonization of distinct enteric viruses, which are otherwise controlled by intraepithelial lymphocytes that, though, do not block colitis exacerbation due to altered virome.
Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis
Germinal center-derived, T cell-dependent secretory IgA prevents chronic intestinal
colonization by select enteroviruses. In its absence, antigen-driven CD8αβ⁺ intraepithelial
lymphocytes partially co...
www.cell.com
April 13, 2025 at 3:20 PM
#WeekendRead! #ImmunoglobulinPower! Jabri &co show @cp-cellhostmicrobe.bsky.social that intestinal IgAs prevent chronic colonization of distinct enteric viruses, which are otherwise controlled by intraepithelial lymphocytes that, though, do not block colitis exacerbation due to altered virome.