Seetha Krishnan
@neurosk.bsky.social
Postdoc at UChicago, Sheffield Lab - Interested in the interplay between neuromodulation, reward, and memory circuits in the brain.| VTA, Hippocampus, NAc | NIDA T32 K01
Pinned
Seetha Krishnan
@neurosk.bsky.social
· Dec 2
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality
Contextual fear conditioning is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous ...
www.biorxiv.org
Happy to share our work on CFC paradigms using head-fixed mice in VR. We elicited freezing as a conditioned response, making the paradigm comparable to freely moving setups and compatible with techniques requiring head fixation, like 2p microscopy/stimulation. #neuroscience 🧠 doi.org/10.1101/2024...
Reposted by Seetha Krishnan
🚨📃New Wassum Lab Paper📃🚨
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
A dual-pathway architecture for stress to disrupt agency and promote habit - Nature
Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...
www.nature.com
February 19, 2025 at 11:37 PM
🚨📃New Wassum Lab Paper📃🚨
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Reposted by Seetha Krishnan
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Learning produces an orthogonalized state machine in the hippocampus
YouTube video by Weinan Sun
www.youtube.com
February 12, 2025 at 7:36 PM
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
Reposted by Seetha Krishnan
I know this site only reaches a subset of neuro/ cog professors. If you know a young professor in the area who would benefit from a week of targeted learning about doing good science, good mentoring, networking etc, it would be great if you could forward them: compneurosci.com/Neuro4Pros/i...
Neuro4Pros summer school
NeUroscience Computational
LEAdership Retreat (NUCLEAR): happiness and success
compneurosci.com
February 5, 2025 at 2:59 PM
I know this site only reaches a subset of neuro/ cog professors. If you know a young professor in the area who would benefit from a week of targeted learning about doing good science, good mentoring, networking etc, it would be great if you could forward them: compneurosci.com/Neuro4Pros/i...
Reposted by Seetha Krishnan
📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! #Neuroskyence
Read about the technique here: www.biorxiv.org/content/10.1...
Read about the technique here: www.biorxiv.org/content/10.1...
January 15, 2025 at 6:35 PM
📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! #Neuroskyence
Read about the technique here: www.biorxiv.org/content/10.1...
Read about the technique here: www.biorxiv.org/content/10.1...
Reposted by Seetha Krishnan
Apropos of everything 🌎, we're declaring it "Fear and Anxiety Week" here on Bsky. It's like shark week but better!
This week, we'll hear about fear and anxiety from brain researchers, psychiatrists, clinical psychologists, and individuals with lived experience.
We invite you to chime in! 1/n
This week, we'll hear about fear and anxiety from brain researchers, psychiatrists, clinical psychologists, and individuals with lived experience.
We invite you to chime in! 1/n
January 12, 2025 at 11:22 AM
Apropos of everything 🌎, we're declaring it "Fear and Anxiety Week" here on Bsky. It's like shark week but better!
This week, we'll hear about fear and anxiety from brain researchers, psychiatrists, clinical psychologists, and individuals with lived experience.
We invite you to chime in! 1/n
This week, we'll hear about fear and anxiety from brain researchers, psychiatrists, clinical psychologists, and individuals with lived experience.
We invite you to chime in! 1/n
Reposted by Seetha Krishnan
What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...
January 12, 2025 at 7:55 PM
What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...
Reposted by Seetha Krishnan
I'm delighted to share this special issue on scientific histories of hippocampal research in the journal Hippocampus - lots of interesting stories and a great resource for trainees. Huge thanks to Mike Hasselmo and Lynn Nadel for their vision and leadership! onlinelibrary.wiley.com/doi/toc/10.1...
Special Issue on Scientific Histories of Hippocampal Research: Hippocampus
Hippocampus is an international neuroscience journal exploring the hippocampal formation and its interactions with other brain regions.
onlinelibrary.wiley.com
January 8, 2025 at 4:20 PM
I'm delighted to share this special issue on scientific histories of hippocampal research in the journal Hippocampus - lots of interesting stories and a great resource for trainees. Huge thanks to Mike Hasselmo and Lynn Nadel for their vision and leadership! onlinelibrary.wiley.com/doi/toc/10.1...
Reposted by Seetha Krishnan
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
December 1, 2024 at 8:29 PM
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
Reposted by Seetha Krishnan
Is oxytocin really "a female hormone"?
Here's a snippet of something new I've been working on: an analysis of every (EVERY) neuroscience grant NIH has issued from 2013 - 2023. For grants focused on various hormones and neurotransmitters, here is the likelihood the grant had a male PI
Here's a snippet of something new I've been working on: an analysis of every (EVERY) neuroscience grant NIH has issued from 2013 - 2023. For grants focused on various hormones and neurotransmitters, here is the likelihood the grant had a male PI
January 3, 2025 at 1:58 AM
Is oxytocin really "a female hormone"?
Here's a snippet of something new I've been working on: an analysis of every (EVERY) neuroscience grant NIH has issued from 2013 - 2023. For grants focused on various hormones and neurotransmitters, here is the likelihood the grant had a male PI
Here's a snippet of something new I've been working on: an analysis of every (EVERY) neuroscience grant NIH has issued from 2013 - 2023. For grants focused on various hormones and neurotransmitters, here is the likelihood the grant had a male PI
Reposted by Seetha Krishnan
Bummer that @zachtpennington.bsky.social is missing #ACNP2024 due to stomach flu. But be sure to check out his discovery about how the anterior hypothalamus codes stress 👇
This is one of the most important, surprising, and exciting findings I've been a part of!
This is one of the most important, surprising, and exciting findings I've been a part of!
❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
December 10, 2024 at 4:37 PM
Bummer that @zachtpennington.bsky.social is missing #ACNP2024 due to stomach flu. But be sure to check out his discovery about how the anterior hypothalamus codes stress 👇
This is one of the most important, surprising, and exciting findings I've been a part of!
This is one of the most important, surprising, and exciting findings I've been a part of!
Reposted by Seetha Krishnan
Help bluesky neurohivemind!
If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!
If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!
December 7, 2024 at 6:06 PM
Help bluesky neurohivemind!
If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!
If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!
Reposted by Seetha Krishnan
I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...
Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
www.nature.com
December 4, 2024 at 7:08 PM
I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...
Reposted by Seetha Krishnan
Hey #ACNP2024 attendees, UAB Neurobiology is looking to recruit 4 faculty in the areas of addiction neuroscience, iPSC/organoids, and neurodevelopmental disorders. All searches are open rank. Specific ads are forthcoming, but you can also apply at this link!
uab.peopleadmin.com/postings/18636
uab.peopleadmin.com/postings/18636
School of Medicine - Open Rank Neurosciences Strategic Hire
The University of Alabama at Birmingham* (UAB) Heersink School of Medicine (HSOM)** is recruiting up to 20 investigators as part of a major strategic initiative in the Neurosciences to build on a stro...
uab.peopleadmin.com
December 8, 2024 at 11:28 PM
Hey #ACNP2024 attendees, UAB Neurobiology is looking to recruit 4 faculty in the areas of addiction neuroscience, iPSC/organoids, and neurodevelopmental disorders. All searches are open rank. Specific ads are forthcoming, but you can also apply at this link!
uab.peopleadmin.com/postings/18636
uab.peopleadmin.com/postings/18636
Happy to share our work on CFC paradigms using head-fixed mice in VR. We elicited freezing as a conditioned response, making the paradigm comparable to freely moving setups and compatible with techniques requiring head fixation, like 2p microscopy/stimulation. #neuroscience 🧠 doi.org/10.1101/2024...
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality
Contextual fear conditioning is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous ...
www.biorxiv.org
December 2, 2024 at 4:09 PM
Happy to share our work on CFC paradigms using head-fixed mice in VR. We elicited freezing as a conditioned response, making the paradigm comparable to freely moving setups and compatible with techniques requiring head fixation, like 2p microscopy/stimulation. #neuroscience 🧠 doi.org/10.1101/2024...
Reposted by Seetha Krishnan
I am old so I can say this: innovation in neuroscience research can be accelerated if we did not waste so much resources repeating what we already know from NHP and rat research in Cre mouse lines
November 25, 2024 at 6:14 PM
I am old so I can say this: innovation in neuroscience research can be accelerated if we did not waste so much resources repeating what we already know from NHP and rat research in Cre mouse lines
Reposted by Seetha Krishnan
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
November 25, 2024 at 4:31 PM
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
Reposted by Seetha Krishnan
There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
November 19, 2024 at 1:23 PM
There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
Reposted by Seetha Krishnan
Reposted by Seetha Krishnan
Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns
www.fiercebiotech.com/research/rep...
www.fiercebiotech.com/research/rep...
Report: Every dollar of NIH research funding doubles in economic returns
Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an
www.fiercebiotech.com
November 17, 2024 at 1:05 PM
Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns
www.fiercebiotech.com/research/rep...
www.fiercebiotech.com/research/rep...
Reposted by Seetha Krishnan
We wrote a review on analysis methods for large-scale neural recordings www.science.org/stoken/autho... @marius10p.bsky.social #neuroscience 🧪🧠
Anything we missed? Reply w/ your fav method!
Anything we missed? Reply w/ your fav method!
November 15, 2024 at 1:18 PM
We wrote a review on analysis methods for large-scale neural recordings www.science.org/stoken/autho... @marius10p.bsky.social #neuroscience 🧪🧠
Anything we missed? Reply w/ your fav method!
Anything we missed? Reply w/ your fav method!