Murillo R.
@mufernando.bsky.social
Computational biology and evolutionary genetics. PhD in Biology at the University of Oregon with Andrew Kern and Peter Ralph. From 🇧🇷. https://m-rodrigues.me
Reposted by Murillo R.
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Murillo R.
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
Reposted by Murillo R.
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Murillo R.
Agouti doing what it does best: making color patterns and jumping between species 🖤🤍
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
www.science.org
October 20, 2025 at 1:57 PM
Agouti doing what it does best: making color patterns and jumping between species 🖤🤍
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Murillo R.
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.10.16.682755v1
October 16, 2025 at 7:32 PM
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.10.16.682755v1
Reposted by Murillo R.
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!
October 15, 2025 at 12:52 PM
I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!
Reposted by Murillo R.
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
Reposted by Murillo R.
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports
CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.
www.consumerreports.org
October 14, 2025 at 4:37 PM
my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)
www.consumerreports.org/lead/protein...
Reposted by Murillo R.
Just an absolutely horrific self own, depleting the US of amazing students from all over the world who contributed to what used to make America great: its diversity, its openness, and its leadership in education.
The number of international students arriving in the U.S. in August fell by 19% this year compared with last year — the largest decline on record outside of the pandemic.
Nearly 20 Percent Fewer International Students Traveled to the U.S. in August
The data shows the steepest decline in August international student arrivals since the pandemic.
nyti.ms
October 6, 2025 at 4:40 PM
Just an absolutely horrific self own, depleting the US of amazing students from all over the world who contributed to what used to make America great: its diversity, its openness, and its leadership in education.
Reposted by Murillo R.
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 25, 2025 at 9:20 PM
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I just had to hop through 5 papers to find the original methods (2025 -> 2018 -> 2014 -> 2013 -> 2005). what is your highest score? 🤯
September 25, 2025 at 11:14 PM
I just had to hop through 5 papers to find the original methods (2025 -> 2018 -> 2014 -> 2013 -> 2005). what is your highest score? 🤯
Reposted by Murillo R.
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
September 24, 2025 at 8:33 PM
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
Reposted by Murillo R.
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
September 22, 2025 at 5:29 AM
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
www.biorxiv.org/content/10.1...
(1/n)
Reposted by Murillo R.
Our paper Genomic diversity of the African malaria vector Anopheles funestus was published in Science today! It features inversions, selection in action, museum specimens and putative new ecotypes. doi.org/10.1126/scie...
September 18, 2025 at 6:45 PM
Our paper Genomic diversity of the African malaria vector Anopheles funestus was published in Science today! It features inversions, selection in action, museum specimens and putative new ecotypes. doi.org/10.1126/scie...
Reposted by Murillo R.
It's 2025, so I feel like it's a stretch to slice the analyses of the same handful of genomes into three or more papers...
September 10, 2025 at 2:36 AM
It's 2025, so I feel like it's a stretch to slice the analyses of the same handful of genomes into three or more papers...
this keeps me up at night. I can’t imagine monkeys surviving the 2800km trip from Africa to South America…
Mammals rafting across the ocean to reach South America and Madagascar
I mean, I can buy reptiles and turtles (low metabolism), but mammals have to constantly eat and drink water? I just don't buy it.
I mean, I can buy reptiles and turtles (low metabolism), but mammals have to constantly eat and drink water? I just don't buy it.
September 9, 2025 at 5:01 AM
this keeps me up at night. I can’t imagine monkeys surviving the 2800km trip from Africa to South America…
Reposted by Murillo R.
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
September 3, 2025 at 6:51 PM
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Reposted by Murillo R.
Announcing SimHumanity, a baseline SLiM 5.0 model of the full human genome, replete with demographic history, autosomes, X/Y, and mtDNA. A shared starting point for reproducible evolutionary simulations. We’d love your feedback! #SLiM #evolution #genomics www.biorxiv.org/content/10.1...
SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution
The reconstruction of human evolutionary history has undergone repeated advances, each made possible by methodological innovations. In recent decades, genetic and genomic data played a central role in...
www.biorxiv.org
September 3, 2025 at 3:27 AM
Announcing SimHumanity, a baseline SLiM 5.0 model of the full human genome, replete with demographic history, autosomes, X/Y, and mtDNA. A shared starting point for reproducible evolutionary simulations. We’d love your feedback! #SLiM #evolution #genomics www.biorxiv.org/content/10.1...
Reposted by Murillo R.
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Murillo R.
Why do males and females often differ in traits?
The expected answer: selection.
But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same
The expected answer: selection.
But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same
August 23, 2025 at 11:12 PM
Why do males and females often differ in traits?
The expected answer: selection.
But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same
The expected answer: selection.
But our new paper in GENETICS shows that genetic drift alone can generate sexual dimorphism — even when male & female optima are the same
Reposted by Murillo R.
#NIH is hanging by a thread. The #CDC has been decimated. #RFK Jr. and Russell #Vought are psychopaths--I don't say this frivolously--they are cold, calculating, inflicting violence on millions through public policy. It is where we are right now. These men are not normal. 1/
August 28, 2025 at 9:55 AM
Reposted by Murillo R.
Genomics hivemind: I want to genotype a bunch of diverse, heterozygous diploids with a messy genome (🌽 -- who'd have guessed?) but I care about phase. Computational phasing doesn't really cut it, so wondering what the cheapest alternatives are -- nanopore to 10-20X? Linked shortreads?
August 27, 2025 at 7:54 PM
Genomics hivemind: I want to genotype a bunch of diverse, heterozygous diploids with a messy genome (🌽 -- who'd have guessed?) but I care about phase. Computational phasing doesn't really cut it, so wondering what the cheapest alternatives are -- nanopore to 10-20X? Linked shortreads?
Reposted by Murillo R.
Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.
🔗 arxiv.org/abs/2508.03958
1/6
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.
🔗 arxiv.org/abs/2508.03958
1/6
tskit_arg_visualizer: interactive plotting of ancestral recombination graphs
Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...
arxiv.org
August 19, 2025 at 2:12 PM
Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.
🔗 arxiv.org/abs/2508.03958
1/6
@yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs.
🔗 arxiv.org/abs/2508.03958
1/6