Miguel Reyes-Múgica, MD
@mreyesm.bsky.social
Director- Ped & Perinat Pathol. U Miami. Standing WHO Ed.B. Expert Editor WHO PAED5. Former Yale Professor 1994-2008; Former EIC @PedDevPath (2001-2016). Advocate for Pediatric Pathology around the world. “Development Is the Key” #PediPath
Reposted by Miguel Reyes-Múgica, MD
For children and teens, heart and blood vessel complications of Covid overshadow the very rare and short-term risk of vaccinations, a new report from nearly 14 million kids
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
November 5, 2025 at 12:48 AM
For children and teens, heart and blood vessel complications of Covid overshadow the very rare and short-term risk of vaccinations, a new report from nearly 14 million kids
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Miguel Reyes-Múgica, MD
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Chimpanzees rationally revise their beliefs
The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...
www.science.org
October 31, 2025 at 1:52 AM
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Reposted by Miguel Reyes-Múgica, MD
Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity
@annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
@annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults | Annals of Internal Medicine
Background: Although physical activity recommendations increasingly consider daily step counts, it remains unclear whether step accumulation patterns—short versus sustained longer bouts—affect associa...
www.acpjournals.org
October 28, 2025 at 7:29 AM
Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity
@annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
@annalsofim.bsky.social
www.acpjournals.org/doi/10.7326/...
Amazing video and description of Ectopia Cordis in the
@NEJM
! I have seen and written about this rare congenital heart and thoracic malformation. nejm.org/doi/full/10.... Pediatric Pathology> 1 I :85-95, 1991 & American Journal of Medical Genetics 44540 (1992)
#PediPath
@NEJM
! I have seen and written about this rare congenital heart and thoracic malformation. nejm.org/doi/full/10.... Pediatric Pathology> 1 I :85-95, 1991 & American Journal of Medical Genetics 44540 (1992)
#PediPath
October 24, 2025 at 2:03 PM
Amazing video and description of Ectopia Cordis in the
@NEJM
! I have seen and written about this rare congenital heart and thoracic malformation. nejm.org/doi/full/10.... Pediatric Pathology> 1 I :85-95, 1991 & American Journal of Medical Genetics 44540 (1992)
#PediPath
@NEJM
! I have seen and written about this rare congenital heart and thoracic malformation. nejm.org/doi/full/10.... Pediatric Pathology> 1 I :85-95, 1991 & American Journal of Medical Genetics 44540 (1992)
#PediPath
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions
Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically
complex set of rare diseases of undefined pathogenesis, including mycosis fungoides
(MF), lymphomatoid papulosis (Ly...
www.modernpathology.org
October 24, 2025 at 2:01 PM
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Reposted by Miguel Reyes-Múgica, MD
A vaccine that helps to fight cancer might already exist: People being treated for deadly cancers lived longer if they had received an mRNA COVID-19 vaccine.
The vaccines have this apparent life-extending effect not because they protect against COVID-19 but because they rev up the immune system.
The vaccines have this apparent life-extending effect not because they protect against COVID-19 but because they rev up the immune system.
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 22, 2025 at 3:15 PM
A vaccine that helps to fight cancer might already exist: People being treated for deadly cancers lived longer if they had received an mRNA COVID-19 vaccine.
The vaccines have this apparent life-extending effect not because they protect against COVID-19 but because they rev up the immune system.
The vaccines have this apparent life-extending effect not because they protect against COVID-19 but because they rev up the immune system.
Reposted by Miguel Reyes-Múgica, MD
In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...
bjsm.bmj.com/content/earl...
October 22, 2025 at 12:22 AM
In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...
bjsm.bmj.com/content/earl...
Reposted by Miguel Reyes-Múgica, MD
Spotify is running ICE ads. I went to cancel on mobile and saw that this isn’t allowed on mobile. They make you cancel on desktop. You think that’s gonna stop me, Spotify? I will erase you and forget you ever existed.
THOU SHALT CANCEL SPOTIFY!!!
THOU SHALT CANCEL SPOTIFY!!!
October 19, 2025 at 5:03 PM
Spotify is running ICE ads. I went to cancel on mobile and saw that this isn’t allowed on mobile. They make you cancel on desktop. You think that’s gonna stop me, Spotify? I will erase you and forget you ever existed.
THOU SHALT CANCEL SPOTIFY!!!
THOU SHALT CANCEL SPOTIFY!!!
Reposted by Miguel Reyes-Múgica, MD
“Wound Man” is an illustration which first appeared in European surgical texts during the Middle Ages. It laid out schematically the various wounds a person might suffer in battle or in accidents, with accompanying text stating treatments.
It's Friday! Tag yourself as a wound 🫠
It's Friday! Tag yourself as a wound 🫠
October 17, 2025 at 10:38 AM
“Wound Man” is an illustration which first appeared in European surgical texts during the Middle Ages. It laid out schematically the various wounds a person might suffer in battle or in accidents, with accompanying text stating treatments.
It's Friday! Tag yourself as a wound 🫠
It's Friday! Tag yourself as a wound 🫠
Reposted by Miguel Reyes-Múgica, MD
A new world record for ultra rapid whole genome sequencing and interpretation for critically ill individuals less than 4hrs! www.nejm.org/doi/full/10....
Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM
Decisions about critical care are almost always made without access to genetic information.
The authors report the application of a new method of DNA sequencing in infants in
a neonatal intensive c...
www.nejm.org
October 15, 2025 at 3:29 PM
A new world record for ultra rapid whole genome sequencing and interpretation for critically ill individuals less than 4hrs! www.nejm.org/doi/full/10....
Reposted by Miguel Reyes-Múgica, MD
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Highly relevant paper for #PediPath: www.nature.com/articles/s41...
Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling - Scientific Reports
Scientific Reports - Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling
www.nature.com
October 9, 2025 at 3:17 PM
Highly relevant paper for #PediPath: www.nature.com/articles/s41...
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions
Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically
complex set of rare diseases of undefined pathogenesis, including mycosis fungoides
(MF), lymphomatoid papulosis (Ly...
www.modernpathology.org
October 9, 2025 at 3:17 PM
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Reposted by Miguel Reyes-Múgica, MD
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down. n.pr/3KIfcSn
This 4-year-old's heart is failing. A federal grant that might help him was canceled
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
n.pr
October 9, 2025 at 1:02 PM
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down. n.pr/3KIfcSn
#PediPath Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions
Pediatric cutaneous T-cell lymphoproliferative disorders encompass a diagnostically
complex set of rare diseases of undefined pathogenesis, including mycosis fungoides
(MF), lymphomatoid papulosis (Ly...
www.modernpathology.org
October 9, 2025 at 12:20 PM
#PediPath Genomic profiling of pediatric mycosis fungoides, lymphomatoid papulosis z, and primary cutaneous anaplastic large cell lymphoma identifies recurrent tyrosine kinase gene fusions - Modern Pathology www.modernpathology.org/article/S089...
Reposted by Miguel Reyes-Múgica, MD
Some arrive, others depart. John Gurdon, Nobel Laureate 2012, has passed.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 7:49 PM
Some arrive, others depart. John Gurdon, Nobel Laureate 2012, has passed.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Reposted by Miguel Reyes-Múgica, MD
"Anyone who is interested in the current and future states of healthspan treatments can appreciate......"—Prof @ctmurphy1.bsky.social @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
October 7, 2025 at 12:31 AM
"Anyone who is interested in the current and future states of healthspan treatments can appreciate......"—Prof @ctmurphy1.bsky.social @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Miguel Reyes-Múgica, MD
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
October 5, 2025 at 9:08 AM
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
Reposted by Miguel Reyes-Múgica, MD
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 6:56 PM
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Miguel Reyes-Múgica, MD
September 29, 1964: the first Mafalda comic strip appears in Primera Plana magazine. The rest is history.
September 30, 2025 at 1:05 AM
September 29, 1964: the first Mafalda comic strip appears in Primera Plana magazine. The rest is history.
Reposted by Miguel Reyes-Múgica, MD
This seems like a good time to repost this thread…. 💉
With science falling under increasing attack, this medical historian is here to remind people of the power of #vaccines. THREAD🧵
Hard-hitting polio advert from 1958. In the first half of the 20th century, polio was the leading cause of death in children and young adults. 1/7
Hard-hitting polio advert from 1958. In the first half of the 20th century, polio was the leading cause of death in children and young adults. 1/7
September 25, 2025 at 6:13 PM
This seems like a good time to repost this thread…. 💉
Reposted by Miguel Reyes-Múgica, MD
The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.
www.science.org
September 24, 2025 at 6:47 PM
The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Reposted by Miguel Reyes-Múgica, MD
In places like Baltimore, for example, the gap between inner-city and suburban residents can add up to a staggering 20 years.
Read more ⬇️
Read more ⬇️
September 24, 2025 at 7:40 PM
In places like Baltimore, for example, the gap between inner-city and suburban residents can add up to a staggering 20 years.
Read more ⬇️
Read more ⬇️
Interesting article, relevant to #PediPath! Transformative Research in Cystic Fibrosis | New England Journal of Medicine www.nejm.org/doi/full/10....
Transformative Research in Cystic Fibrosis | NEJM
Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey
Clinical Medical Research Award for their roles in developing treatments for cystic
fibrosis.
www.nejm.org
September 25, 2025 at 12:46 PM
Interesting article, relevant to #PediPath! Transformative Research in Cystic Fibrosis | New England Journal of Medicine www.nejm.org/doi/full/10....