Moritz Bauer
@moritzbauer.bsky.social
Post-Doc @hubrechtinstitute.bsky.social @jopkind.bsky.social. PhD @crg.eu PayerLab. Epigenetics, the X and single-cell technologies.
Pinned
Moritz Bauer
@moritzbauer.bsky.social
· Dec 3
📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/...
Big thanks to Hendrik Marks for taking the lead this time!
Big thanks to Hendrik Marks for taking the lead this time!
Reposted by Moritz Bauer
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 7:56 AM
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
Great place for a PhD with one of the smartest minds in the field!
Fascinated by protein homeostasis, stem cells and development? I am recruiting PhD candidates through the fabulous IMPRS-CellDevoSys program. This place is buzzing with great science and brilliant minds. Come join!
If you are interested in a PhD in the area of "Mechanisms of Genome Stability" and "Functional Genomics of Proteome Remodelling," apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
October 22, 2025 at 11:07 AM
Great place for a PhD with one of the smartest minds in the field!
Great PhD opportunity with a fantastic mentor!
Are you interested in a PhD in the area of "Mechanisms of translational control during embryogenesis?" Apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
October 3, 2025 at 5:37 AM
Great PhD opportunity with a fantastic mentor!
Reposted by Moritz Bauer
1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis
During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...
doi.org
September 17, 2025 at 8:41 AM
1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social
Reposted by Moritz Bauer
Finally out on @devbiol.bsky.social: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰.
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice
The Polycomb repressive complex 2 (PRC2) is an essential modulator of gene repression. We previously reported that, in mouse embryonic stem cells, PRC…
www.sciencedirect.com
August 25, 2025 at 7:44 PM
Finally out on @devbiol.bsky.social: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰.
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
Bonus: Epop has maternal effect!
Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social
Great use of DamID to use it as a history tracing tool!
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 11:41 AM
Great use of DamID to use it as a history tracing tool!
Reposted by Moritz Bauer
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
www.nature.com
July 10, 2025 at 2:36 PM
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Great new paper from the lab highlighting the utility of multimodal single-cell readouts!
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
www.nature.com
July 10, 2025 at 7:05 PM
Great new paper from the lab highlighting the utility of multimodal single-cell readouts!
Reposted by Moritz Bauer
🧬 Looking for a PhD position in molecular or developmental biology? 🔬
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
July 10, 2025 at 11:19 AM
🧬 Looking for a PhD position in molecular or developmental biology? 🔬
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
Reposted by Moritz Bauer
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
shorturl.at
May 16, 2025 at 7:45 AM
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Reposted by Moritz Bauer
🚨 Paper Alert 🚨
I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉
Check out the full paper here:
www.cell.com/developmenta...
@dewitlab.bsky.social , @bracciolilab.bsky.social 🙌
🧵👇
I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉
Check out the full paper here:
www.cell.com/developmenta...
@dewitlab.bsky.social , @bracciolilab.bsky.social 🙌
🧵👇
Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids
Braccioli et al. use time-resolved single-cell chromatin accessibility analysis to
study mouse gastruloid development. They identify key transcription factors driving
mesoderm and spinal cord differen...
www.cell.com
March 18, 2025 at 9:30 AM
🚨 Paper Alert 🚨
I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉
Check out the full paper here:
www.cell.com/developmenta...
@dewitlab.bsky.social , @bracciolilab.bsky.social 🙌
🧵👇
I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉
Check out the full paper here:
www.cell.com/developmenta...
@dewitlab.bsky.social , @bracciolilab.bsky.social 🙌
🧵👇
Reposted by Moritz Bauer
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Moritz Bauer
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
February 5, 2025 at 6:34 PM
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
Reposted by Moritz Bauer
A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored....
doi.org
December 23, 2024 at 4:01 PM
A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....
📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/...
Big thanks to Hendrik Marks for taking the lead this time!
Big thanks to Hendrik Marks for taking the lead this time!
December 3, 2024 at 10:46 AM
📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/...
Big thanks to Hendrik Marks for taking the lead this time!
Big thanks to Hendrik Marks for taking the lead this time!
Reposted by Moritz Bauer
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
November 29, 2024 at 12:30 PM
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
Reposted by Moritz Bauer
Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social
Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM
Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM
November 27, 2024 at 11:45 AM
Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social
Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM
Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM