Mishtu Dey
@mishtudey.bsky.social
Editor-in-Chief @Cell Chemical Biology (@cellchembiol.bsky.social). Passionate about the impact of chemical biology.
Reposted by Mishtu Dey
The November issue of Cell Chemical Biology is live! Click here to read: www.cell.com/issue/S2451-...
November 20, 2025 at 7:43 PM
The November issue of Cell Chemical Biology is live! Click here to read: www.cell.com/issue/S2451-...
Reposted by Mishtu Dey
Online now! Online now! TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics #chembiol
TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics
Yuan et al. identify TRIM28 as a key component of stress granules (SGs) using the lcFAX-MS approach established here and define TRIM28-mediated G3BP1/2 SUMOylation as a critical mechanism regulating SG dynamics. TRIM28’s role in regulating SGs, facilitated by lcFAX-MS, provides a promising framework for studying diverse LLPS events.
dlvr.it
November 5, 2025 at 4:30 PM
Online now! Online now! TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics #chembiol
Reposted by Mishtu Dey
Online now! STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency #chembiol
STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency
Loss of RNF43 leads to aberrant Wnt signaling, promoting aggressive cancers for which effective treatments are lacking. He et al. demonstrate that STT3A is critical for the survival of RNF43-deficient tumors, identifying it as a promising therapeutic target validated through both in vitro and in vivo studies.
dlvr.it
October 22, 2025 at 3:30 PM
Online now! STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency #chembiol
Check out our collection @cp-cellchembiol.bsky.social on molecular mechanism of host-microbiome interaction
Explore our collection w/ @cp-cellhostmicrobe.bsky.social: Molecular Mechanisms of Host-Microbiome Interactions. Discover the cross talk between microbes and their human hosts that shapes health and disease. http://dlvr.it/TNrk90
October 30, 2025 at 8:43 PM
Check out our collection @cp-cellchembiol.bsky.social on molecular mechanism of host-microbiome interaction
Reposted by Mishtu Dey
Online now! Online now! Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression #chembiol
Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression
Targeting the WDR5-MLL1 interaction offers a promising therapeutic strategy for leukemia. Zhang et al. developed Ac7, an EMBOW-derived peptide that binds WDR5 with nanomolar affinity, disrupts the WDR5-MLL1 interaction, and suppresses leukemia cell growth in vivo with relatively low toxicity.
dlvr.it
October 27, 2025 at 3:30 PM
Online now! Online now! Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression #chembiol
@cp-cellchembiol.bsky.social is now on LinkendIn! Please follow us here: www.linkedin.com/company/1069...
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May 13, 2025 at 5:51 PM
@cp-cellchembiol.bsky.social is now on LinkendIn! Please follow us here: www.linkedin.com/company/1069...
Reposted by Mishtu Dey
With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids
www.nature.com/articles/s41...
www.nature.com/articles/s41...
bsky.app
March 14, 2025 at 10:39 AM
With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mishtu Dey
Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches by Yi Rao and colleagues at @PKU1898, @chinese_brain, Peking-Tsinghua Center for Life Sciences http://dlvr.it/THQXFd
January 17, 2025 at 7:01 PM
Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches by Yi Rao and colleagues at @PKU1898, @chinese_brain, Peking-Tsinghua Center for Life Sciences http://dlvr.it/THQXFd
Reposted by Mishtu Dey
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain by Sidharth S. Madhavan, John Newman @GeriSciDoc, et al at @BuckInstitute @USC @USCLeonardDavis @UCSF @IthacaCollege http://dlvr.it/THQZnx
January 17, 2025 at 8:01 PM
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain by Sidharth S. Madhavan, John Newman @GeriSciDoc, et al at @BuckInstitute @USC @USCLeonardDavis @UCSF @IthacaCollege http://dlvr.it/THQZnx
Reposted by Mishtu Dey
#Technology Degradome analysis to identify direct protein substrates of small-molecule degraders by @Ma_Jochem, @Krijgsveld_lab, and colleagues at @DKFZ @CeMM_News @UniHeidelberg http://dlvr.it/THQcwD
January 17, 2025 at 9:01 PM
#Technology Degradome analysis to identify direct protein substrates of small-molecule degraders by @Ma_Jochem, @Krijgsveld_lab, and colleagues at @DKFZ @CeMM_News @UniHeidelberg http://dlvr.it/THQcwD
Reposted by Mishtu Dey
Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch http://dlvr.it/THQfvX
January 17, 2025 at 10:02 PM
Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch http://dlvr.it/THQfvX
Reposted by Mishtu Dey
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al. at @Cambridge_Uni http://dlvr.it/THYqLx
January 24, 2025 at 7:00 PM
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al. at @Cambridge_Uni http://dlvr.it/THYqLx
Reposted by Mishtu Dey
Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org
Upcoming Speakers | Targeted Protein Degradation Webinar Series
www.danafarbertargetedproteindegradation.org
January 22, 2025 at 5:25 PM
Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org
Reposted by Mishtu Dey
Interesting talk by Paul Hensbergen from the LUMC at #NPP2025. He talked about his work in collaboration with the @smitslab.bsky.social on studying Clostridioides difficile with (glyco)proteomics. Exciting insights into glyosylation of the flagellum. pubs.acs.org/doi/10.1021/...
January 17, 2025 at 1:47 PM
Interesting talk by Paul Hensbergen from the LUMC at #NPP2025. He talked about his work in collaboration with the @smitslab.bsky.social on studying Clostridioides difficile with (glyco)proteomics. Exciting insights into glyosylation of the flagellum. pubs.acs.org/doi/10.1021/...
Read this insightful Voices where @judith-behnsen.bsky.social and others share their perspectives on how advances in chemical biology approaches provide new opportunities for mechanistic and functional investigation of the microbiome. www.cell.com/cell-chemica...
January 17, 2025 at 1:48 PM
Read this insightful Voices where @judith-behnsen.bsky.social and others share their perspectives on how advances in chemical biology approaches provide new opportunities for mechanistic and functional investigation of the microbiome. www.cell.com/cell-chemica...
Reposted by Mishtu Dey
Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Madhavan et al. identify and characterize the selective regulation of protein solubility
by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure
rescues cell-based and C. ele...
www.cell.com
December 2, 2024 at 10:06 PM
Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Read @cp-cellchembiol.bsky.social 's latest Focus Issue on Chemical Biology of the Microbiome here: www.cell.com/issue/S2451-...
January 17, 2025 at 1:19 PM
Read @cp-cellchembiol.bsky.social 's latest Focus Issue on Chemical Biology of the Microbiome here: www.cell.com/issue/S2451-...
Reposted by Mishtu Dey
Reposted by Mishtu Dey
Online now! Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders by @jtang162, @DanHarki, and colleagues at @UMN_MedChem @UMNews @UTHealthSA @HHMINEWS @UCSanDiego http://dlvr.it/THDH9Z
January 7, 2025 at 7:30 PM
Online now! Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders by @jtang162, @DanHarki, and colleagues at @UMN_MedChem @UMNews @UTHealthSA @HHMINEWS @UCSanDiego http://dlvr.it/THDH9Z
Reposted by Mishtu Dey
Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW
Molecular mechanisms in RNA biology: Cell Press
dlvr.it
December 30, 2024 at 5:31 PM
Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW
Reposted by Mishtu Dey
An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it).
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Also features G.K. Chesterton and a brief cameo by RFK Jr.
HPV Infections: Friend and Foe
www.science.org
December 18, 2024 at 9:17 PM
An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it).
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Also features G.K. Chesterton and a brief cameo by RFK Jr.
Reposted by Mishtu Dey
DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:
Computational Care
www.science.org
December 6, 2024 at 5:01 PM
DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:
Reposted by Mishtu Dey
Thank you @mishtudey.bsky.social and the other organizers for a fantastic symposium. The talks covered broad areas of chemical biology-from targeted protein degradation and molecular glues to sensor development and immuno-oncology. They also represented a nice blend of academic and industry efforts.
December 5, 2024 at 4:47 PM
Thank you @mishtudey.bsky.social and the other organizers for a fantastic symposium. The talks covered broad areas of chemical biology-from targeted protein degradation and molecular glues to sensor development and immuno-oncology. They also represented a nice blend of academic and industry efforts.
Reposted by Mishtu Dey
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
December 1, 2024 at 10:37 PM
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
Reposted by Mishtu Dey
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
December 4, 2024 at 8:53 PM
First paper of our lab today @natureportfolio.bsky.social by Nussi!
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0
We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!
@embl.org #RNAbiology #RNASky
t.co/a24Xxcxdo0