Mike Krashes
@mikekrashes.bsky.social
Your arms too short to box with god
Reposted by Mike Krashes
🚨📃New Wassum Lab Paper📃🚨
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
A dual-pathway architecture for stress to disrupt agency and promote habit - Nature
Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...
www.nature.com
February 19, 2025 at 11:37 PM
🚨📃New Wassum Lab Paper📃🚨
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
Reposted by Mike Krashes
www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort
Thalamic opioids from POMC satiety neurons switch on sugar appetite
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...
www.science.org
February 14, 2025 at 7:51 AM
www.science.org/doi/10.1126/... very excited to share our latest work, out now in Science. Congratulations to Marielle who led our studies! And, all other authors - this was a wonderful collaborative effort
Reposted by Mike Krashes
New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...
Aggression experience and observation promote shared behavioral and neural changes
The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...
www.biorxiv.org
January 2, 2025 at 5:33 PM
New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes www.biorxiv.org/content/10.1...
Reposted by Mike Krashes
We're so excited to join the party over here! Follow this account to learn more about the latest papers published in Nature Neuroscience!
December 18, 2024 at 2:27 PM
We're so excited to join the party over here! Follow this account to learn more about the latest papers published in Nature Neuroscience!
Reposted by Mike Krashes
Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate 🧠. Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 17, 2024 at 1:46 PM
Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate 🧠. Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mike Krashes
My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... )
Here is the gist 🧵 (1/n):
Here is the gist 🧵 (1/n):
Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience
Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...
www.nature.com
December 10, 2024 at 9:59 PM
My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... )
Here is the gist 🧵 (1/n):
Here is the gist 🧵 (1/n):
Reposted by Mike Krashes
Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist
Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.
www.science.org
December 4, 2024 at 8:27 PM
Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mike Krashes
@mikekrashes.bsky.social on GLP-1.
Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue
www.cell.com/current-biol...
www.cell.com/current-biol...
Glucagon-like peptide-1 receptor
Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role
in glucose metabolism and the mode of action of their agonists that are used to treat
obesity and were later shown...
www.cell.com
December 4, 2024 at 1:01 PM
@mikekrashes.bsky.social on GLP-1.
Reposted by Mike Krashes
NIH’s own @mikekrashes.bsky.social telling it like it is.
Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue
www.cell.com/current-biol...
www.cell.com/current-biol...
Glucagon-like peptide-1 receptor
Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role
in glucose metabolism and the mode of action of their agonists that are used to treat
obesity and were later shown...
www.cell.com
December 4, 2024 at 2:04 AM
NIH’s own @mikekrashes.bsky.social telling it like it is.
Reposted by Mike Krashes
Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue
www.cell.com/current-biol...
www.cell.com/current-biol...
Glucagon-like peptide-1 receptor
Michael Krashes discusses glucagon-like peptide-1 receptors, their physiological role
in glucose metabolism and the mode of action of their agonists that are used to treat
obesity and were later shown...
www.cell.com
December 3, 2024 at 7:38 PM
Everyone is talking about #Ozempic #Wegovy which are agonists of the GLP-1 receptor. For more about this receptor and its physiological role, see the quickguide by Michael Krashes in our latest issue
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Mike Krashes
New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5
Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety
Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.
rdcu.be
December 3, 2024 at 1:40 PM
New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5
A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...
authors.elsevier.com
December 2, 2024 at 4:51 PM
A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it) authors.elsevier.com/a/1kCED3QW8S...
Reposted by Mike Krashes
We've joined the blue skies.
Follow along to those interested in all things ingestive behavior.
Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/
Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺
Follow along to those interested in all things ingestive behavior.
Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/
Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺
November 27, 2024 at 4:54 PM
We've joined the blue skies.
Follow along to those interested in all things ingestive behavior.
Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/
Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺
Follow along to those interested in all things ingestive behavior.
Also, be sure to check out SSIB2025 👉 www.ssib.org/2025/
Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁
Neuropsychiatry: 🧠🩺
Reposted by Mike Krashes
Stress, GLP1, hypothalamus, NTS, what more could you want? Collaboration across the pond led by the amazing Dr. Marie Holt @MKBHolt www.sciencedirect.com/science/arti...
Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract
Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiologi…
www.sciencedirect.com
November 27, 2024 at 3:18 PM
Stress, GLP1, hypothalamus, NTS, what more could you want? Collaboration across the pond led by the amazing Dr. Marie Holt @MKBHolt www.sciencedirect.com/science/arti...