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mewe03.bsky.social
Melanie Weigert
@mewe03.bsky.social
51 followers 85 following 5 posts
Scientist. Biomarkers. Ovarian Cancer. Travel. Food. My dog. Plants.
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mewe03.bsky.social
Melanie Weigert @mewe03.bsky.social · Jan 3
What a way to start the New Year!
Our manuscript on the single cell pre- and postmenopausal human fallopian tube is out!
www.nature.com/articles/s41...
A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause - Nature Communications
The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealin...
www.nature.com
mewe03.bsky.social
Yes, yes, yes!!!! 🙌🏻🙌🏻🙌🏻
natureportfolio.nature.com Nature Portfolio @natureportfolio.nature.com · Jun 29
Starting July 1, researchers funded by the US National Institutes of Health will be required to make their scientific papers available to read for free as soon as they are published in a peer-reviewed journal. Nature asks experts what researchers need to know about the NIH policy. #Academicsky 🧪
NIH-funded science must now be free to read instantly: what you should know
US biomedical agency’s public-access policy kicks in on 1 July. Nature talks to specialists about how to comply.
go.nature.com
June 29, 2025 at 11:46 PM
Reposted by Melanie Weigert
rdrapkin8-penn.bsky.social
Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...
Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications
The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...
www.nature.com
March 27, 2025 at 2:29 PM
mewe03.bsky.social
Looking forward to seeing you all there! #science #standupforscience2025 #phdchat #postdoc #research
standupforscience.bsky.social Stand Up for Science! @standupforscience.bsky.social · Feb 12
Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence
March 4, 2025 at 12:45 AM
Reposted by Melanie Weigert
elizsmckenna.bsky.social
Now online in Cancer Discovery: LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma - by Eunae You, David Ting, and colleagues doi.org/10.1158/2159...
February 10, 2025 at 3:23 PM
mewe03.bsky.social
Always enjoyed joining the syndicate talks! Excellent for early career scientist! #Phd #postdoc #ovariancancer
rdrapkin8-penn.bsky.social Ronny Drapkin @rdrapkin8-penn.bsky.social · Jan 24
The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!
February 8, 2025 at 11:00 PM
mewe03.bsky.social
Interesting, I wonder how having a supportive PI/ lab environment that actually nurtures postdocs and having a lab that is well funded play into these hit publications? #science #academia #phdchat #phdforum #postdoclife

www.pnas.org/doi/10.1073/...
Postdoc publications and citations link to academic retention and faculty success | PNAS
Postdoctoral training is a career stage often described as a demanding and anxiety-laden time when many promising PhDs see their academic dreams sl...
www.pnas.org
January 25, 2025 at 11:16 PM
Reposted by Melanie Weigert
adamgrant.bsky.social
Personality is how you respond on a typical day. Character is how you show up on a hard day.

It's easy to demonstrate fairness, integrity, and generosity when things are going well.

The real question is whether you stand by those values when the deck is stacked against you.
January 5, 2025 at 7:23 PM
mewe03.bsky.social
What a way to start the New Year!
Our manuscript on the single cell pre- and postmenopausal human fallopian tube is out!
www.nature.com/articles/s41...
A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause - Nature Communications
The fallopian tube undergoes extensive cellular and molecular changes during the menstrual cycle and aging. Here, Weigert et al. present a single-cell atlas of the normal human fallopian tube revealin...
www.nature.com
January 3, 2025 at 3:44 PM
Reposted by Melanie Weigert
lindseyvanhaute.bsky.social
Could breast cancer survival rates be improved simply by timing treatment to a specific stage of the menstrual cycle? Mouse and human data suggest sensitivity to chemotherapy is affected by fluctuations in ovarian hormones.

www.nature.com/articles/d41...
What is the best time of the month to treat breast cancer?
Sensitivity to chemotherapy is affected by hormonal fluctuations.
www.nature.com
December 5, 2024 at 9:37 AM
Reposted by Melanie Weigert
elizsmckenna.bsky.social
Now online in Cancer Discovery: Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma - by Tanjina Kader, Jia-Ren Lin, Clemens Hug, Ronny Drapkin, Sandro Santagata, et al. doi.org/10.1158/2159...
Schematic representation of HGSCO progression, emphasizing the temporal development of hallmark cancer features and the dynamic interplay and interactions between immune cells and precancer/cancer cells. Cancer often starts with oncogenic changes (mutations, aneuploidy, and other cancer hallmarks), under selective pressure. These cells may remain latent for decades. Only a subset of these “phenotypically normal” but mutated clones undergo clonal expansion and acquire additional mutations, ultimately developing into cancer. Early on, despite limited genomic instability, innate immune responses, including the NK-cDC1-CTL axis and tissue-resident memory T cells (TRM), help contain p53 signature cells. Increasing aneuploidy or extrinsic factors can enhance immune surveillance, potentially eliminating precancer clones before significant proliferation occurs. During early STIC expansion, there is pronounced IFN response activation, with activated cDC1 and APCs, and NK cell-secreted chemokines, further attracting cDC1. This environment suggests active immune surveillance and is accompanied by interactions among APCs, activated CD4+, and CD8+ T cells. However, immunosuppressive cells, such as M2-like macrophages and Tregs, also emerge, indicating a complex equilibrium where cytotoxic and suppressive forces coexist. As STIC lesions advance, there is a reduction in CD8+ T cells and the interactions between APCs and CD4 T cells, along with an increase in exhausted CD8+ CTL and CD4+ cells expressing LAG3, almost no NK and cDC1 cells, and more suppressive APCs. The transition from STIC to overt cancer involves hallmark mechanisms such as TGF-β signaling, which excludes CTLs, changes in cytokine and fibroblast profiles, and induction of EMT and migratory programs. Dotted arrows indicate the hypothetical timing of these events, suggesting a prolonged interval from p53 signature to early STIC, followed by a more rapid progression from early to late STIC.
December 20, 2024 at 3:54 PM
Reposted by Melanie Weigert
erictopol.bsky.social
Generative #AI accuracy outperformed experts for detection of ovarian cancer via ultrasound
nature.com/articles/s41...
International multicenter validation of AI-driven ultrasound detection of ovarian cancer - Nature Medicine
In a comprehensive dataset from 3,652 patients across 20 centers in eight countries, an ultrasound-based AI model shows robust performance across centers, ultrasound systems, 58 histological diagnoses...
nature.com
January 2, 2025 at 6:55 PM