Matt Coelho
@mattcoelho.bsky.social
Cancer Research UK Career Development Fellow at the Wellcome Sanger Institute - gene editing - drug resistance - cancer
A pleasure to talk about our research today with the amazing volunteers at St John’s ambulance in aid of @cancerresearchuk.org
October 10, 2025 at 8:51 PM
A pleasure to talk about our research today with the amazing volunteers at St John’s ambulance in aid of @cancerresearchuk.org
Reposted by Matt Coelho
Apply for Multiplex Assays of Variant Effects training by 18 August! ⏰
Join our experts to learn how to strengthen your genetic disease research or clinical work using MAVE data. 🧬
Financial assistance available💸
📎Find out more: bit.ly/3EW3lh4
#MAVE25 #VariantInterpretation
Join our experts to learn how to strengthen your genetic disease research or clinical work using MAVE data. 🧬
Financial assistance available💸
📎Find out more: bit.ly/3EW3lh4
#MAVE25 #VariantInterpretation
July 17, 2025 at 7:00 AM
Apply for Multiplex Assays of Variant Effects training by 18 August! ⏰
Join our experts to learn how to strengthen your genetic disease research or clinical work using MAVE data. 🧬
Financial assistance available💸
📎Find out more: bit.ly/3EW3lh4
#MAVE25 #VariantInterpretation
Join our experts to learn how to strengthen your genetic disease research or clinical work using MAVE data. 🧬
Financial assistance available💸
📎Find out more: bit.ly/3EW3lh4
#MAVE25 #VariantInterpretation
Reposted by Matt Coelho
Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
August 7, 2025 at 2:26 PM
Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
Reposted by Matt Coelho
Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets www.nature.com/articles/s41...
Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets - Nature Biotechnology
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.
www.nature.com
August 7, 2025 at 2:50 PM
Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets www.nature.com/articles/s41...
Looking to combine ML and functional genomics to tackle cancer drug resistance? Exciting job opening at the Sanger!
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Principal Software Developer/Computational Biologist
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
July 25, 2025 at 7:45 PM
Looking to combine ML and functional genomics to tackle cancer drug resistance? Exciting job opening at the Sanger!
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Reposted by Matt Coelho
May 22, 2025 at 8:09 AM
Reposted by Matt Coelho
🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments https://www.biorxiv.org/content/10.1101/2025.05.19.654892v1
May 22, 2025 at 1:21 PM
🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor
Reposted by Matt Coelho
Reposted by Matt Coelho
Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social
Building AI models or the data to train them?
Core funding of >$130M a year for a faculty of ~30.
www.nature.com/naturecareer...
acrobat.adobe.com/id/urn:aaid:...
pls RT!
Building AI models or the data to train them?
Core funding of >$130M a year for a faculty of ~30.
www.nature.com/naturecareer...
acrobat.adobe.com/id/urn:aaid:...
pls RT!
May 6, 2025 at 2:59 PM
Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social
Building AI models or the data to train them?
Core funding of >$130M a year for a faculty of ~30.
www.nature.com/naturecareer...
acrobat.adobe.com/id/urn:aaid:...
pls RT!
Building AI models or the data to train them?
Core funding of >$130M a year for a faculty of ~30.
www.nature.com/naturecareer...
acrobat.adobe.com/id/urn:aaid:...
pls RT!
Excited to announce our preprint today @biorxivpreprint.bsky.social
Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells:
www.biorxiv.org/content/10.1...
Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells:
www.biorxiv.org/content/10.1...
CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
Cancer immunotherapy is only effective in a subset of patients, highlighting the need for effective biomarkers and combination therapies. Here we systematically identify genetic determinants of cancer...
www.biorxiv.org
April 22, 2025 at 7:56 AM
Excited to announce our preprint today @biorxivpreprint.bsky.social
Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells:
www.biorxiv.org/content/10.1...
Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells:
www.biorxiv.org/content/10.1...
less than one week remaining to apply 👇
Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing.
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
March 27, 2025 at 12:53 PM
less than one week remaining to apply 👇
Reposted by Matt Coelho
New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
February 25, 2025 at 4:17 PM
New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing.
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
March 12, 2025 at 1:50 PM
Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing.
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Interested?
Apply here:
sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Reposted by Matt Coelho
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
March 5, 2025 at 6:56 PM
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
Today in BJC Reports, we summarise the outcomes from a multidisciplinary workshop focused on addressing cancer drug resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance - BJC Reports
BJC Reports - Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance
www.nature.com
February 28, 2025 at 9:21 AM
Today in BJC Reports, we summarise the outcomes from a multidisciplinary workshop focused on addressing cancer drug resistance.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Matt Coelho
Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social
Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning
Nature Communications - Multi-omics integration is often limited by data sparsity and heterogeneity. Here, the authors develop MOSA, a method designed to augment DepMap cell line data to...
rdcu.be
November 29, 2024 at 2:53 PM
Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social
Reposted by Matt Coelho
last couple days to apply (for free! from anywhere in the world!) to the Sanger 2025 PhD Programme — Deadline: 28th November 2024 (09:00 GMT)
For more info, visit www.sanger.ac.uk/about/study/...
For more info, visit www.sanger.ac.uk/about/study/...
November 25, 2024 at 6:34 PM
last couple days to apply (for free! from anywhere in the world!) to the Sanger 2025 PhD Programme — Deadline: 28th November 2024 (09:00 GMT)
For more info, visit www.sanger.ac.uk/about/study/...
For more info, visit www.sanger.ac.uk/about/study/...
Applications are now open for the Sanger prize! A 3 month placement - undergraduates from low and middle income countries encouraged to apply
www.sanger.ac.uk/about/the-sa...
www.sanger.ac.uk/about/the-sa...
The Sanger Prize Competition 2025
Sanger Prize competiton 2025 for undergraduates interested in genomics, who are from low- and middle-income countries
www.sanger.ac.uk
November 19, 2024 at 5:43 PM
Applications are now open for the Sanger prize! A 3 month placement - undergraduates from low and middle income countries encouraged to apply
www.sanger.ac.uk/about/the-sa...
www.sanger.ac.uk/about/the-sa...