Mashek Lab
@masheklab.bsky.social
Professor at the University of Minnesota studying lipid droplets, metabolism, nutrition, metabolic diseases, and aging.
Reposted by Mashek Lab
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
@berkeleymcb.bsky.social
bit.ly/49mTeyF
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
bit.ly
November 16, 2025 at 8:38 AM
☕ @mikelangelipid.bsky.social @olzmannlab.bsky.social & co identify a #LipidDroplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of #ferroptosis.
@berkeleymcb.bsky.social
bit.ly/49mTeyF
@berkeleymcb.bsky.social
bit.ly/49mTeyF
Reposted by Mashek Lab
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
www.nature.com
August 20, 2025 at 10:01 PM
Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...
Reposted by Mashek Lab
Understanding the predictors of metabolic dysfunction-associated steatotic liver disease—
ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M
ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M
June 26, 2025 at 5:38 PM
Understanding the predictors of metabolic dysfunction-associated steatotic liver disease—
ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M
ASCI member Peter Crawford & team suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation: buff.ly/f26w63M
Super excited to share our new publication identifying the food preservative, sorbic acid, as a new PTM. Even cooler is that the deacylation and acylation of this PTM is catalyzed by the non-canonical activity of Class I HDACs using free sorbate (not sorbyl-CoA) www.science.org/doi/10.1126/...
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes
Sorbic acid regulates inflammatory gene expression through the mechanism of lysine sorbylation.
www.science.org
May 30, 2025 at 7:56 PM
Super excited to share our new publication identifying the food preservative, sorbic acid, as a new PTM. Even cooler is that the deacylation and acylation of this PTM is catalyzed by the non-canonical activity of Class I HDACs using free sorbate (not sorbyl-CoA) www.science.org/doi/10.1126/...
Reposted by Mashek Lab
We recently published
@geroscience.bsky.social
the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1...
We now report a detailed step-by-step resource paper describing how to conduct the mSFI.
bio-protocol.org/en/bpdetail?...
@geroscience.bsky.social
the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1...
We now report a detailed step-by-step resource paper describing how to conduct the mSFI.
bio-protocol.org/en/bpdetail?...
April 2, 2025 at 6:37 AM
We recently published
@geroscience.bsky.social
the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1...
We now report a detailed step-by-step resource paper describing how to conduct the mSFI.
bio-protocol.org/en/bpdetail?...
@geroscience.bsky.social
the development and validation of the mouse social frailty index (mSFI) link.springer.com/article/10.1...
We now report a detailed step-by-step resource paper describing how to conduct the mSFI.
bio-protocol.org/en/bpdetail?...
Reposted by Mashek Lab
Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social
Excited to share that work from my PhD is now available in @natmetabolism.bsky.social! Here, we uncover a link between heme production, BCAA metabolism, and thermogenesis—implicating heme synthesis in #aging, #obesity, and #T2D.
Link to paper: urldefense.com/v3/__https:/...
A Thread (1/15)
Link to paper: urldefense.com/v3/__https:/...
A Thread (1/15)
Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
Nature Metabolism - Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs...
urldefense.com
March 25, 2025 at 2:41 PM
Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social
Reposted by Mashek Lab
What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...
February 2, 2025 at 11:51 AM
What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...
Reposted by Mashek Lab
New from
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍
doi.org/10.1111/boc....
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍
doi.org/10.1111/boc....
Neutral lipids restrict the mobility of broken DNA molecules during comet assays
This study reveals that neutral lipids (NL), naturally present in cells, become trapped within genomic DNA as a consequence of the standard execution of the comet assay, a technique used to measure D...
doi.org
January 25, 2025 at 11:05 AM
New from
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍
doi.org/10.1111/boc....
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍
doi.org/10.1111/boc....