Mashek Lab
@masheklab.bsky.social
Professor at the University of Minnesota studying lipid droplets, metabolism, nutrition, metabolic diseases, and aging.
Congrats! Groundbreaking work!
October 30, 2025 at 10:03 PM
Congrats! Groundbreaking work!
These data are in agreement with www.nature.com/articles/s41... from @dremilygoldberg.bsky.social showing that HDAC1-3 can acylate proteins using fatty acids rather than their acyl-CoA derivatives as substrates. This raises many questions about epigenomic regulation via changes in metabolism.
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
May 30, 2025 at 8:03 PM
These data are in agreement with www.nature.com/articles/s41... from @dremilygoldberg.bsky.social showing that HDAC1-3 can acylate proteins using fatty acids rather than their acyl-CoA derivatives as substrates. This raises many questions about epigenomic regulation via changes in metabolism.
Congrats. This is very cool!
April 19, 2025 at 9:08 PM
Congrats. This is very cool!
Congrats! That is so cool. I hope you are getting some royalties….
February 7, 2025 at 9:27 PM
Congrats! That is so cool. I hope you are getting some royalties….
Can’t wait to read this. Congrats!
January 25, 2025 at 1:02 PM
Can’t wait to read this. Congrats!