Martin Picard
@martinpicardenergy.bsky.social
Mitochondrial Psychobiology. Bridging the science of energy and the human experience to create Healing Science. Upcoming book: ENERGY (2027).
Pinned
The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
Spectacular time of year
November 10, 2025 at 12:33 AM
Spectacular time of year
Reposted by Martin Picard
“Look again at that dot. That's here. That's home. That's us. On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives…. on a mote of dust suspended in a sunbeam.”
-the Pale Blue Dot by Carl Sagan ✨🌏
-the Pale Blue Dot by Carl Sagan ✨🌏
November 9, 2025 at 6:42 PM
“Look again at that dot. That's here. That's home. That's us. On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives…. on a mote of dust suspended in a sunbeam.”
-the Pale Blue Dot by Carl Sagan ✨🌏
-the Pale Blue Dot by Carl Sagan ✨🌏
Interested in energy-based thinking around health?
Interested in mitochondria and body-mind processes?
Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th.
Poster abstract submission open.
www.picardlab.org/misbie
Interested in mitochondria and body-mind processes?
Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th.
Poster abstract submission open.
www.picardlab.org/misbie
MiSBIE Study
The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study is a NIH-funded research platform allowing investigators to ask deeply interdisciplinary questions around brain-body processes,....
www.picardlab.org
November 6, 2025 at 11:15 PM
Interested in energy-based thinking around health?
Interested in mitochondria and body-mind processes?
Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th.
Poster abstract submission open.
www.picardlab.org/misbie
Interested in mitochondria and body-mind processes?
Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th.
Poster abstract submission open.
www.picardlab.org/misbie
The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
November 2, 2025 at 3:20 PM
The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
@msahsorin.bsky.social
authors.elsevier.com/a/1luVK5WXUl...
Quite likely that abnormal cellular metabolism (excess energy resistance, éR) is a driver of inflammation and atherosclerosis
#Throwback 🧪
REVIEW | Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
A Yurdagul et al.
REVIEW | Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
A Yurdagul et al.
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities - Nature Metabolism
Yurdagul and colleagues offer an integrated picture of metabolic changes at the cellular and at the lesion level in atherosclerosis.
bit.ly
November 2, 2025 at 3:15 PM
Quite likely that abnormal cellular metabolism (excess energy resistance, éR) is a driver of inflammation and atherosclerosis
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism
Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...
www.nature.com
October 30, 2025 at 3:52 PM
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Martin Picard
Just leaving this right here....👀
October 30, 2025 at 11:22 AM
Just leaving this right here....👀
Reposted by Martin Picard
Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
Mitonuclear interactions and early-life diet shape adult nutritional behaviour
Abstract. Mitochondrial function relies on close coordination between the mitochondrial and nuclear genomes. Disruption to this coordination—via mitonuclea
academic.oup.com
October 20, 2025 at 9:13 AM
Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,
academic.oup.com/jeb/advance-...
The fallacies from animal studies applied to humans extend beyond addiction and mental health, likely to calorie restriction and metabolic health.
In attempting to control every variable, we can distort context and conclusions.
Video of Johann Hari
In attempting to control every variable, we can distort context and conclusions.
Video of Johann Hari
October 25, 2025 at 10:42 AM
The fallacies from animal studies applied to humans extend beyond addiction and mental health, likely to calorie restriction and metabolic health.
In attempting to control every variable, we can distort context and conclusions.
Video of Johann Hari
In attempting to control every variable, we can distort context and conclusions.
Video of Johann Hari
"The most precious gift we can offer others is our presence" ⎸ Thich Nhat Hanh
When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with.
It is among the most precious gifts.
Discussion with the brilliant Lily Mujica-Parodi.
When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with.
It is among the most precious gifts.
Discussion with the brilliant Lily Mujica-Parodi.
October 24, 2025 at 10:51 PM
"The most precious gift we can offer others is our presence" ⎸ Thich Nhat Hanh
When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with.
It is among the most precious gifts.
Discussion with the brilliant Lily Mujica-Parodi.
When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with.
It is among the most precious gifts.
Discussion with the brilliant Lily Mujica-Parodi.
Reposted by Martin Picard
Isn’t it interesting that both chlorophyll and heme, 2 most important pigments of life, share the same #quantum architecture?
Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.
Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.
October 23, 2025 at 4:04 PM
Isn’t it interesting that both chlorophyll and heme, 2 most important pigments of life, share the same #quantum architecture?
Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.
Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.
We are exited to welcome Nicco Reggente from the Institute for Advanced Consciousness Studies
His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth
Monday, October 27th, 12pm ET
Zoom link: columbiacuimc.zoom.us/j/5779841445
His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth
Monday, October 27th, 12pm ET
Zoom link: columbiacuimc.zoom.us/j/5779841445
October 23, 2025 at 8:24 PM
We are exited to welcome Nicco Reggente from the Institute for Advanced Consciousness Studies
His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth
Monday, October 27th, 12pm ET
Zoom link: columbiacuimc.zoom.us/j/5779841445
His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth
Monday, October 27th, 12pm ET
Zoom link: columbiacuimc.zoom.us/j/5779841445
Automn when the trees let go of their leaves is spectacular
October 23, 2025 at 2:33 AM
Automn when the trees let go of their leaves is spectacular
Reposted by Martin Picard
BOLD signal changes can oppose oxygen metabolism across the human cortex | bioRxiv www.biorxiv.org/content/10.1...
October 22, 2025 at 12:41 AM
BOLD signal changes can oppose oxygen metabolism across the human cortex | bioRxiv www.biorxiv.org/content/10.1...
Love it! All of the most actionable knowledge lies at the intersection of disciplines. Kudos for engaging in this way.
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform
the study of ‘higher’ cognitive functions such as learning and memory across model
systems.
www.cell.com
October 20, 2025 at 8:22 PM
Love it! All of the most actionable knowledge lies at the intersection of disciplines. Kudos for engaging in this way.
Reposted by Martin Picard
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
October 20, 2025 at 3:59 PM
🚨Publication alert! 🚨
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
Why does stress drive psychopathology & transdiagnostic disease?
We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.
www.sciencedirect.com/science/arti...
The brain did not evolve to think, but to regulate our energetic state.
Several brain regions involved in cognition work together to monitor and coordinate psychological processes.
Beautiful paper on the neuroscience behind allostasis by Jordan Theriault.
www.cell.com/neuron/fullt...
Several brain regions involved in cognition work together to monitor and coordinate psychological processes.
Beautiful paper on the neuroscience behind allostasis by Jordan Theriault.
www.cell.com/neuron/fullt...
October 19, 2025 at 6:49 PM
The brain did not evolve to think, but to regulate our energetic state.
Several brain regions involved in cognition work together to monitor and coordinate psychological processes.
Beautiful paper on the neuroscience behind allostasis by Jordan Theriault.
www.cell.com/neuron/fullt...
Several brain regions involved in cognition work together to monitor and coordinate psychological processes.
Beautiful paper on the neuroscience behind allostasis by Jordan Theriault.
www.cell.com/neuron/fullt...
Every day, without missing a beat, the sun rises and throws its energy at us
October 19, 2025 at 12:07 PM
Every day, without missing a beat, the sun rises and throws its energy at us
New book covering the many functions of mitochondria, by Daria Mochly-Rosen and Emanuel Rosen
October 19, 2025 at 12:03 PM
New book covering the many functions of mitochondria, by Daria Mochly-Rosen and Emanuel Rosen
Most processes in life require cycling, including firing neurons, the heart contraction/relaxation cycle, sleep/wake rhythms, and many more.
#Throwback 🧪
PERSPECTIVE | The cyclic metabolic switching theory of intermittent fasting
Mark Mattson
PERSPECTIVE | The cyclic metabolic switching theory of intermittent fasting
Mark Mattson
The cyclic metabolic switching theory of intermittent fasting - Nature Metabolism
In this Perspective, Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and non-ketogenic (fed) states and that this explains the added health benefits of IF over caloric restriction and ketogenic diets.
bit.ly
October 19, 2025 at 11:57 AM
Most processes in life require cycling, including firing neurons, the heart contraction/relaxation cycle, sleep/wake rhythms, and many more.
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
October 17, 2025 at 2:42 AM
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
Wonderful meeting organized by @johnspeakman4.bsky.social on energy in Shenzhen—I learnt so much! Thank you.
Below John humoring the dancing robot 😅
Below John humoring the dancing robot 😅
October 16, 2025 at 4:31 PM
Wonderful meeting organized by @johnspeakman4.bsky.social on energy in Shenzhen—I learnt so much! Thank you.
Below John humoring the dancing robot 😅
Below John humoring the dancing robot 😅
Reposted by Martin Picard
Out now in @natmetabolism.nature.com 🧪
FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors.
Read the full study by @martinpicardenergy.bsky.social here:
doi.org/10.1038/s422...
FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors.
Read the full study by @martinpicardenergy.bsky.social here:
doi.org/10.1038/s422...
October 14, 2025 at 11:15 AM
Out now in @natmetabolism.nature.com 🧪
FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors.
Read the full study by @martinpicardenergy.bsky.social here:
doi.org/10.1038/s422...
FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors.
Read the full study by @martinpicardenergy.bsky.social here:
doi.org/10.1038/s422...
Deep questions @ricardsole.bsky.social
Maybe by understanding death we can understand the energetic nature of life a little better?
Maybe by understanding death we can understand the energetic nature of life a little better?
What is the physical basis of death? Can we manipulate cellular rules to avoid it? What does death mean for a machine? Is immortality possible? What does it mean for language, thought, or information to die? My new book @princetonupress.bsky.social is coming soon. press.princeton.edu/books/hardco...
October 16, 2025 at 4:25 PM
Deep questions @ricardsole.bsky.social
Maybe by understanding death we can understand the energetic nature of life a little better?
Maybe by understanding death we can understand the energetic nature of life a little better?
The metabolic hormone FGF21 is one of the most studied hormone in the field of diabetes and energy metabolism.
We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.
We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.
October 16, 2025 at 4:21 PM
The metabolic hormone FGF21 is one of the most studied hormone in the field of diabetes and energy metabolism.
We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.
We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.