Marc de Manuel
@marcdemanuel.bsky.social
Group Leader at the Institute for Evolutionary Biology (Barcelona), learning about how mutations originate.
lab website: www.demanuellab.com
lab website: www.demanuellab.com
Reposted by Marc de Manuel
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 3, 2025 at 3:56 PM
Very happy to share our work on signature SBS5. See Molly's thread for a short summary
Reposted by Marc de Manuel
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Marc de Manuel
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Reposted by Marc de Manuel
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
June 1, 2025 at 3:33 PM
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
Truly honored to be appointed an Ambassador for the ERC. Looking forward to keep advocating for the importance of frontier science in Spain, Europe, and beyond.
🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
April 29, 2025 at 8:50 AM
Truly honored to be appointed an Ambassador for the ERC. Looking forward to keep advocating for the importance of frontier science in Spain, Europe, and beyond.
Reposted by Marc de Manuel
🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
April 29, 2025 at 7:01 AM
🚀 We are proud to launch the new "Ambassadors for the ERC" initiative, together with @ercgrantees.bsky.social !
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
We aim to empower researchers across Europe to advocate for frontier research. Find out more 👉 bit.ly/44bQzp7
🌟 Excited to see what can be achieved!
#Amb4ERC
Reposted by Marc de Manuel
Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.
2025 Human Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
April 24, 2025 at 2:31 PM
Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.
Reposted by Marc de Manuel
🔊 We're Hiring! 🔊
The #IBE seeks a Post-award Research Project Manager - European Projects. 🌍
📄 Full-time | 🕒 2-year renewable contract
📆 Apply by: 4th May
Explore all our #JobOffers & #JoinOurTeam 👉 https://www.ibe.upf-csic.es/work-with-us/job-offers
The #IBE seeks a Post-award Research Project Manager - European Projects. 🌍
📄 Full-time | 🕒 2-year renewable contract
📆 Apply by: 4th May
Explore all our #JobOffers & #JoinOurTeam 👉 https://www.ibe.upf-csic.es/work-with-us/job-offers
April 23, 2025 at 9:19 AM
🔊 We're Hiring! 🔊
The #IBE seeks a Post-award Research Project Manager - European Projects. 🌍
📄 Full-time | 🕒 2-year renewable contract
📆 Apply by: 4th May
Explore all our #JobOffers & #JoinOurTeam 👉 https://www.ibe.upf-csic.es/work-with-us/job-offers
The #IBE seeks a Post-award Research Project Manager - European Projects. 🌍
📄 Full-time | 🕒 2-year renewable contract
📆 Apply by: 4th May
Explore all our #JobOffers & #JoinOurTeam 👉 https://www.ibe.upf-csic.es/work-with-us/job-offers
Reposted by Marc de Manuel
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Marc de Manuel
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...
The distribution of highly deleterious variants across human ancestry groups
A major focus of human genetics is to map severe disease mutations. Increasingly that goal is understood as requiring huge numbers of people to be sequenced from every broadly-defined genetic ancestry...
www.biorxiv.org
February 2, 2025 at 7:00 PM
“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...
Last days to apply!
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
January 4, 2025 at 9:09 AM
Last days to apply!
Reposted by Marc de Manuel
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
November 25, 2024 at 11:19 AM
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
Reposted by Marc de Manuel
Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos
December 5, 2024 at 3:47 PM
Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
November 25, 2024 at 11:19 AM
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
Reposted by Marc de Manuel
📢 Are you interested in doing a PhD in Life Sciences #VHIO?
🎓 PhD call open: 8-10 fully funded scholarships for international Life Sciences & Medical students 🧬 🩺
Apply now 👉 linke.to/PHDFellowshi...
🗓 Deadline for applications: 29th November 2024
🎓 PhD call open: 8-10 fully funded scholarships for international Life Sciences & Medical students 🧬 🩺
Apply now 👉 linke.to/PHDFellowshi...
🗓 Deadline for applications: 29th November 2024
PhD Fellowships - VHIO
linke.to
November 21, 2024 at 10:35 AM
📢 Are you interested in doing a PhD in Life Sciences #VHIO?
🎓 PhD call open: 8-10 fully funded scholarships for international Life Sciences & Medical students 🧬 🩺
Apply now 👉 linke.to/PHDFellowshi...
🗓 Deadline for applications: 29th November 2024
🎓 PhD call open: 8-10 fully funded scholarships for international Life Sciences & Medical students 🧬 🩺
Apply now 👉 linke.to/PHDFellowshi...
🗓 Deadline for applications: 29th November 2024
Reposted by Marc de Manuel
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
November 22, 2024 at 4:45 PM
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
Reposted by Marc de Manuel
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
November 20, 2024 at 10:46 AM
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
Reposted by Marc de Manuel
Accepting postdoc applications to work on a broad range of topics including gene regulatory variation, response eQTL mapping, complex traits, comparative genomics in primates, and predictive models.
November 19, 2024 at 3:33 AM
Accepting postdoc applications to work on a broad range of topics including gene regulatory variation, response eQTL mapping, complex traits, comparative genomics in primates, and predictive models.
Reposted by Marc de Manuel
Here's a starter pack of people on here who I've found and who I know are excellent Science Communicators.
Give them a follow:
go.bsky.app/4SAvt2B
Give them a follow:
go.bsky.app/4SAvt2B
November 14, 2024 at 10:50 AM
Here's a starter pack of people on here who I've found and who I know are excellent Science Communicators.
Give them a follow:
go.bsky.app/4SAvt2B
Give them a follow:
go.bsky.app/4SAvt2B
Reposted by Marc de Manuel
A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...
November 15, 2024 at 9:56 AM
A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...
Reposted by Marc de Manuel
I'm recruiting students / postdocs to join my new lab at the University of Rochester for Fall 2025 onwards! If you're interested in phylogenetic comparative methods, genome evolution, and/or computational biology, please get in touch! More info:
mhibbins.github.io
mhibbins.github.io
Hibbins Lab
mhibbins.github.io
October 2, 2024 at 8:01 PM
I'm recruiting students / postdocs to join my new lab at the University of Rochester for Fall 2025 onwards! If you're interested in phylogenetic comparative methods, genome evolution, and/or computational biology, please get in touch! More info:
mhibbins.github.io
mhibbins.github.io
Bioinformatics folks working on HPCs—anyone got a go-to alternative to vscode? It’s become mysteriously slow and unresponsive on our system lately
November 13, 2024 at 7:19 PM
Bioinformatics folks working on HPCs—anyone got a go-to alternative to vscode? It’s become mysteriously slow and unresponsive on our system lately
Reposted by Marc de Manuel
The new program of Evolutionary Medical Genomics, lead by @mirimiam.bsky.social, and shared between our Institute, CRG & UPF will hold its 1st symposium next week. Our work on unicellular relatives of animals and tumorigenesis will be represented by Yosuke.
Link: evomedgenomics.com/events/inaug...
Link: evomedgenomics.com/events/inaug...
November 13, 2024 at 9:27 AM
The new program of Evolutionary Medical Genomics, lead by @mirimiam.bsky.social, and shared between our Institute, CRG & UPF will hold its 1st symposium next week. Our work on unicellular relatives of animals and tumorigenesis will be represented by Yosuke.
Link: evomedgenomics.com/events/inaug...
Link: evomedgenomics.com/events/inaug...
Reposted by Marc de Manuel
🧬🐭🐴🐻Job Alert🐻🐴🐭🧬
We are hiring 3 postdoctoral researchers in DeepTime Palaeogenomics!
All positions are for 2 years (extension possible), & are fully funded both in terms of employment and project costs.
Deadline: 2 Dec 2024
Please RT!
Apply:
www.su.se/english/abou...
We are hiring 3 postdoctoral researchers in DeepTime Palaeogenomics!
All positions are for 2 years (extension possible), & are fully funded both in terms of employment and project costs.
Deadline: 2 Dec 2024
Please RT!
Apply:
www.su.se/english/abou...
November 13, 2024 at 10:19 AM
🧬🐭🐴🐻Job Alert🐻🐴🐭🧬
We are hiring 3 postdoctoral researchers in DeepTime Palaeogenomics!
All positions are for 2 years (extension possible), & are fully funded both in terms of employment and project costs.
Deadline: 2 Dec 2024
Please RT!
Apply:
www.su.se/english/abou...
We are hiring 3 postdoctoral researchers in DeepTime Palaeogenomics!
All positions are for 2 years (extension possible), & are fully funded both in terms of employment and project costs.
Deadline: 2 Dec 2024
Please RT!
Apply:
www.su.se/english/abou...
Reposted by Marc de Manuel
Hi all! I'm excited to announce a tenure track faculty position in conservation genomics in EEB at UCLA! We're looking for candidates who use genomic tools to study evolutionary processes related to conservation. Note, the actual application deadline is Nov 29. recruit.apo.ucla.edu/JPF09875
Conservation Genomics Faculty Position
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
November 12, 2024 at 5:19 PM
Hi all! I'm excited to announce a tenure track faculty position in conservation genomics in EEB at UCLA! We're looking for candidates who use genomic tools to study evolutionary processes related to conservation. Note, the actual application deadline is Nov 29. recruit.apo.ucla.edu/JPF09875