Manini AF
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maninialex.bsky.social
Manini AF
@maninialex.bsky.social
Professor @MountSinaiNYC, views my own.
Director and Founder of Mount Sinai RESPOND Center.
https://icahn.mssm.edu/about/departments/emergency-medicine/research/respond-center
See more https://youtu.be/NJpBa3tDVB4
Pinned
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Exciting news: Our team has been awarded a NIDA R01 grant to fund "Fentalog II", a continuation of our groundbreaking collaboration to detect novel fentanyl analogue overdoses in EDs across ten major hospitals over five years. #syntheticopioids
#Medsky 🧵
www.mountsinai.org/about/newsro...
Mount Sinai Receives $3.8 Million Grant to Study New Synthetic Drugs and Opioid Overdoses in Emergency Departments to Prevent Deaths
www.mountsinai.org
1/ 🚨 New TOXIC Fentalog quarterly report on multi-city toxicology testing shows fentanyl & other synthetic drugs dominate suspected overdose cases in US ERs. Findings offer a near real-time look at the street drug market. #medsky #PublicHealth 🧵
www.cfsre.org/nps-discover...
ToxIC Fentalog Study Group - Quarterly NPS Report: Q2 2025
www.cfsre.org
August 14, 2025 at 2:10 PM
Reposted by Manini AF
Publication: Black patients less likely than white patients to receive outpatient treatment referrals after #opioid #overdose ED visits, per ToxIC Fentalog study. Findings underscore need to address disparities in post-overdose care. ➡️ bit.ly/4l1hFE2
@jamanetworkopen.com @maninialex.bsky.social
July 28, 2025 at 5:56 PM
Reposted by Manini AF
🚨Publication Alert🚨 bit.ly/46U3nl6
#Xylazine found in 1 in 5 nonfatal #opioid #overdoses across 10 U.S. EDs, mostly alongside #fentanyl. Exposure highest in NE vs. rare in the West. Regional trends underscore need for targeted public health responses. #MedToxTuesday
@maninialex.bsky.social
July 22, 2025 at 4:54 PM
Reposted by Manini AF
🚨Publication Alert🚨These findings focused on the presence of para-fluorofentanyl (PFF) point to important differences in OD response/treatment linked to fentanyl analogs w/ sex-specific effects that merit further investigation. 📖https://bit.ly/3Gv0gp3
@ziadkazzi.bsky.social @maninialex.bsky.social
July 7, 2025 at 9:15 PM
Reposted by Manini AF
Among patients with opioid overdose in emergency departments, Black patients received outpatient referrals less frequently than White patients, with rates of 5.7% versus 9.6%. https://ja.ma/44kiKjO
July 2, 2025 at 4:15 PM
July 1. Day One.
- You will feel overwhelmed (That’s normal)
- Courage isn't the absence of fear
- Ask for help early and often
- Nobody expects you to know everything
- Efficiency comes with time
- Trust the process
💙 Welcome. We’ve got your back. #InternYear #Medsky
July 1, 2025 at 9:29 PM
Reposted by Manini AF
🚨HUGE SCIENCE WIN ALERT🚨

NIH Grants to be restored en masse!!! Thank you Judge Young for standing up for science!

#StandUpforScience
#SummerFightforScience
BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.
June 16, 2025 at 6:54 PM
Reposted by Manini AF
Tianeptine, or ‘gas station heroin,’ can be addictive and cause serious side effects

WASHINGTON (AP) — Health officials want you to think twice before buying one of those brightly colored little bottles often sold at gas stations, convenience stores and smoke shops. Sometimes called “gas station…
Tianeptine, or ‘gas station heroin,’ can be addictive and cause serious side effects
WASHINGTON (AP) — Health officials want you to think twice before buying one of those brightly colored little bottles often sold at gas stations, convenience stores and smoke shops. Sometimes called “gas station heroin,” the products are usually marketed as energy shots or cognitive supplements but actually contain tianeptine, an unapproved drug that can be addictive and carries risks of serious side effects.
exposenews.xyz
June 14, 2025 at 10:07 PM
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Exciting news: Our team has been awarded a NIDA R01 grant to fund "Fentalog II", a continuation of our groundbreaking collaboration to detect novel fentanyl analogue overdoses in EDs across ten major hospitals over five years. #syntheticopioids
#Medsky 🧵
www.mountsinai.org/about/newsro...
Mount Sinai Receives $3.8 Million Grant to Study New Synthetic Drugs and Opioid Overdoses in Emergency Departments to Prevent Deaths
www.mountsinai.org
June 11, 2025 at 8:14 PM
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Our new study in Academic Emergency Medicine analyzed 1,265 ED patients with severe QTc prolongation (≥500 ms) after drug overdose. What predicts dangerous ventricular dysrhythmias in this high-risk group? #cardiotoxins #overdose
#Medsky 🧵
pubmed.ncbi.nlm.nih.gov/40492421/
Clinical Factors Associated With Ventricular Dysrhythmia in Emergency Department Patients With Severe QTc Prolongation After Drug Overdose - PubMed
In this large international data registry, we identified predictors of ventricular dysrhythmia in patients presenting to the ED after overdose in the setting of severe QTc prolongation.
pubmed.ncbi.nlm.nih.gov
June 11, 2025 at 8:00 PM
Reposted by Manini AF
“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.”

www.science.org/content/arti...

#StandUpForScience
#BethesdaDeclaration
NIH staff and biomedical community sound alarm about agency politicization, funding slowdown
In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes
www.science.org
June 9, 2025 at 4:27 PM
May 14, 2025 at 7:23 PM
Great primer and review of the landscape on Methadone for EM docs and emergency care providers #opioidcrisis #Medsky www.acepnow.com/article/libe...
Liberate Methadone: An Introduction for the Emergency Medicine Physician - ACEP Now
ACEP Now offers real-time clinical news, news from the American College of Emergency Physicians, and news on practice trends and health care reform for the emergency medicine physician. ACEP Now is an...
www.acepnow.com
April 21, 2025 at 4:20 PM
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Something weird is happening at NIH.
For two weeks in a row, the NIH Weekly Guide has listed zero new funding opportunities. That’s not normal. At all. A short thread on why this is a statistical and strategic outlier:
#Medsky
April 11, 2025 at 9:01 PM
Reposted by Manini AF
The Trump administration continues to interfere with medical research, this time by forbidding NIH scientists from attending conferences - even on their own time and paying their own way.

#medsky

www.reuters.com/business/hea...
Exclusive: US NIH scientists barred from attending conferences on their own time and dime
Researchers at the U.S. National Institutes of Health have been told they cannot attend scientific conferences and meetings without official permission, even if they pay their own way and go during time off, three current and former NIH scientists told Reuters.
www.reuters.com
April 10, 2025 at 8:11 PM
1/ Supervised Consumption Sites (SCSs) work — and Canada has the data to prove it. A recent ecological and spatial analysis shows a striking 67% reduction in overdose mortality within 500m of SCSs. #ACMT2025 #PublicHealth
#Medsky
April 3, 2025 at 6:21 PM
Reposted by Manini AF
Caught up on #ThePitt. As an ER charge nurse, I know that mass casualty events are a constant, avoidable reality. Hopefully the show illustrates to even one person the physical and emotional damage from gun violence and moves them to vote for a safer reality for all of us. @everytown.bsky.social
April 2, 2025 at 2:30 PM
Reposted by Manini AF
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
nature.com
April 2, 2025 at 3:29 PM
Reposted by Manini AF
Collecting my thoughts at the end of one of the worst days of my life...

At NIH, > 1300 people were RIFed. These range all across the board from institute directors to low level administrative staff.

Communication staff and procurement appear to be hardest hit as anticipated from the HHS plan

1/n
April 2, 2025 at 12:17 AM
Reposted by Manini AF
There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result.
www.wired.com/story/cdc-gu...
The CDC Has Been Gutted
Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.
www.wired.com
April 1, 2025 at 3:32 PM
Reposted by Manini AF
It’s April 1 and still no news about the noncompetitive renewal of our #NIH #R35 award that should enter year 2 today.

It’s Schrödinger’s grant

How many others are in the same boat? 🧪
April 1, 2025 at 10:46 AM
Reposted by Manini AF
How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
HHS starts layoffs of thousands of workers across its agencies
Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.
www.statnews.com
April 1, 2025 at 2:44 PM
🧵1/5
New NIH Director Jay Bhattacharya outlines bold new priorities in his welcome message to NIH staff. A physician-economist from Stanford, Bhattacharya signals a shift toward outcomes-driven research and public trust-building. Here’s what’s coming... ⬇️
#MedSky
www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
www.nature.com
April 1, 2025 at 8:58 PM
Reposted by Manini AF
🧬 Key scientific leaders are being removed! 🧬

NIH directors—known for their expertise and institutional knowledge—are being ousted

Result?
✅Undermines public health
✅Erodes scientific integrity
✅Risks unchecked actions

A short 🧵

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#NIH #CDC #FDA #AcademicSky #MedSky #Science
On health economist Jay Bhattacharya’s first day as head of the US National Institutes of Health (NIH), the chiefs of four of the 27 institutes and centres that make up his agency were removed from their posts.

https://go.nature.com/3QZ8GGT
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
go.nature.com
April 1, 2025 at 7:31 PM
Reposted by Manini AF