5/ Bottom line: fentanyl still rules, but the “other stuff” — novel benzos, veterinary sedatives, synthetic cannabinoids — is the stealthy threat changing overdose care. Full report: npsdiscovery.org #DrugTrends

4/ Clinically, this underscores why standard opioid panels miss the mark. LC-QTOF-MS detected >1,200 substances, catching dangerous adulterants missed by routine screens. Treatment must anticipate multi-drug toxicity. #EmergencyMedicine
www.cdc.gov/overdose-pre...

3/ Public health takeaway: street drugs are increasingly poly-drug cocktails. Testing found opioids + stimulants + sedatives in the same patient; this complicates outreach, naloxone use, and treatment planning. #OverdosePrevention

2/ A related Fentalog publication last week in AEM noted how lab-made benzos are reshaping #overdose risk. Our data back it up: bromazolam is showing up in multiple cities — often alongside #fentanyl onlinelibrary.wiley.com/doi/10.1111/...

6/
Over the long term, proactive surveillance could shift care from reactive triage to prediction and prevention—offering a model for future responses to dynamic drug crises. #overdoseprevention

5/
Collaboration within the Toxicology Investigators Consortium (ToxIC) ensures a national, multisite approach—boosting generalizability and helping track evolving overdose trends across diverse regions. #toxicology
www.acmt.net/fentanyl-ana...

4/
Clinically, this research will explore whether current naloxone dosing suffices against these potent synthetics. ED docs may need new protocols if higher or novel reversal agents prove necessary. #EDpreparedness

3/
From a public health lens: amid >108,000 overdose deaths in 2023 and 70 % opioid-related, this study aims to integrate real-time data into the CDC Fentalog Nonfatal OD dashboard—enabling region‑specific alerts and proactive intervention. #publichealthalert
www.cdc.gov/overdose-pre...

2/
The work sports strong media resonance: outlets are highlighting how fentanyl analogues and ultra-potent nitazenes—often missed by standard tests—are fueling overdose spikes. #medsky #fentanylepidemic
www1.racgp.org.au/newsgp/clini...

7/
Clinicians: if your overdose patient is bradycardic, acidotic, or in shock and has a QTc ≥500 ms, think ECMO, not observation. #resus #ToxTwitter
pubmed.ncbi.nlm.nih.gov/40492421/

6/
From a public health perspective, these findings underscore the hidden cardiovascular danger of common drugs like diphenhydramine, quetiapine, and loperamide in overdose. #poisonprevention #opioidepidemic

5/
QTc ≥500 ms alone isn’t the full picture. This paper gives clinicians a sharper triage lens: focus on the sickest patients, not just the longest intervals. #EDmedicine #riskstratification

4/
This work builds on growing public concern over OTC and Rx misuse. Years ago, @nytimes covered loperamide (“poor man’s methadone”) causing fatal arrhythmias. This study directly validates that risk. #medsky
www.nytimes.com/2016/05/11/h...

3/
All three signs had strong associations with arrest, death, and ECMO need. Absence of all three? 98.2% NPV for dysrhythmia. #FOAMed #toxicology

2/
Only 3.8% of these patients developed ventricular dysrhythmias. But three simple ED findings—bradycardia, acidosis, and shock—were powerful red flags. #clinicaltox #ekgpearls