@LydiaTeboul
@lydiateboul.bsky.social
French molecular geek and unlikely SCUBA diver
Reposted by @LydiaTeboul
We plan to facilitate replacement training at our Advance training centre and lead the @mrcmousenetwork.bsky.social Best Models Working Group, which provides a forum for researchers to learn about alternative models and connect with experts in other systems
www.har.mrc.ac.uk/services/rep...
www.har.mrc.ac.uk/services/rep...
Replacement of Animals in Medical Research | Mary Lyon Centre
Animals are currently used where there is no scientifically satisfactory alternative, but there has been considerable progress in developing new methodologies that could replace the use of animals in ...
www.har.mrc.ac.uk
November 12, 2025 at 11:31 AM
We plan to facilitate replacement training at our Advance training centre and lead the @mrcmousenetwork.bsky.social Best Models Working Group, which provides a forum for researchers to learn about alternative models and connect with experts in other systems
www.har.mrc.ac.uk/services/rep...
www.har.mrc.ac.uk/services/rep...
Reposted by @LydiaTeboul
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 12, 2025 at 11:31 AM
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
Reposted by @LydiaTeboul
Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.
April 10, 2025 at 12:27 PM
Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.
Reposted by @LydiaTeboul
Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.
Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪
Better understanding of laboratory animal genetics will improve reproducibility
Incomplete characterization and inconsistent reporting of laboratory animal genetics undermine study quality and limit research reproducibility. This Perspective highlights the LAG-R guidelines and…
plos.io
October 31, 2025 at 2:52 PM
Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.
Reposted by @LydiaTeboul
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
nmgn.mrc.ukri.org
October 31, 2025 at 12:20 PM
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
nmgn.mrc.ukri.org/working-grou...
#MeetTheExpert #3Rs
Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.
Incomplete characterization and inconsistent reporting of laboratory animal #genetics undermine study quality and limit research #reproducibility. @reproducibilityexp.bsky.social highlight the LAG-R guidelines and call for collective action to enhance scientific integrity.🧪
Better understanding of laboratory animal genetics will improve reproducibility
Incomplete characterization and inconsistent reporting of laboratory animal genetics undermine study quality and limit research reproducibility. This Perspective highlights the LAG-R guidelines and…
plos.io
October 31, 2025 at 2:52 PM
Characterisation and documentation of experimental models - in vitro and in vivo - for research #reproducibility.
Reposted by @LydiaTeboul
@lydiateboul.bsky.social and Michelle Stewart lend their decades long experience to highlight the need for rigorous documentation in in vivo studies #MouseGenetics #documentation #ScientificRigour
Parent-of-origin of alleles: an essential variable in in vivo experiments:
A new paper from Lydia Teboul and Michelle Stewart highlights the essential role of systematic documentation of genetics and breeding patterns for ensuring reproducibility.
www.nature.com/articles/s41...
A new paper from Lydia Teboul and Michelle Stewart highlights the essential role of systematic documentation of genetics and breeding patterns for ensuring reproducibility.
www.nature.com/articles/s41...
Parent-of-origin of alleles: an essential variable in in vivo experiments
Lab Animal - A recent study introduces a new method to quantify amyloid-β plaques in whole brains of mice to elucidate the variability in expressivity of a transgene widely used in...
www.nature.com
April 3, 2025 at 1:42 PM
@lydiateboul.bsky.social and Michelle Stewart lend their decades long experience to highlight the need for rigorous documentation in in vivo studies #MouseGenetics #documentation #ScientificRigour
Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.
April 10, 2025 at 12:27 PM
Please visit lag-r.org/guidelines/ for handy forms to document the genetics of laboratory animals in publications.
Reposted by @LydiaTeboul
There's still time to complete the straightforward application form for our current Genome Editing Mice for Medicine call before the extended deadline on 31st January to be in with a chance of getting your free, novel, genetically altered mouse model generated
GEMM | Mary Lyon Centre
Submit an application to have your free, novel, genetically altered mouse model generated by the Mary Lyon Centre
www.har.mrc.ac.uk
January 17, 2025 at 1:05 PM
There's still time to complete the straightforward application form for our current Genome Editing Mice for Medicine call before the extended deadline on 31st January to be in with a chance of getting your free, novel, genetically altered mouse model generated
Reposted by @LydiaTeboul
Researchers at Newcastle University have used a conditional mouse mutant made by the MLC's Genome Editing Mice for Medicine (GEMM) programme to investigate a poison exon in the splicing regulator Tra2b that is essential for male fertility:
www.har.mrc.ac.uk/news/a-gemm-...
www.har.mrc.ac.uk/news/a-gemm-...
A GEMM programme mouse model used to investigate a poison exon essential for male fertility | Mary Lyon Centre
Researchers at Newcastle University are using a conditional mouse mutant made by the Mary Lyon Centre’s Genome Editing Mice for Medicine (GEMM) programme to study the role of an ultra-conserved exon in the splicing regulator gene Tra2b. Many genes function as instructions for producing proteins, which perform the majority of tasks within our cells. To […]
www.har.mrc.ac.uk
January 20, 2025 at 11:00 AM
Researchers at Newcastle University have used a conditional mouse mutant made by the MLC's Genome Editing Mice for Medicine (GEMM) programme to investigate a poison exon in the splicing regulator Tra2b that is essential for male fertility:
www.har.mrc.ac.uk/news/a-gemm-...
www.har.mrc.ac.uk/news/a-gemm-...
Part of the reason for mosaicism in genome editing?
Read ‘Prolonged persistence of mutagenic DNA lesions in somatic cells’ from @mikespencerchapman.bsky.social @sangerinstitute.bsky.social @qmbci.bsky.social & others in @nature.com, here ⤵️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.
www.nature.com
January 16, 2025 at 12:33 PM
Part of the reason for mosaicism in genome editing?