Lynch Syndrome Ireland
@lsireland.bsky.social
Central point for Lynch syndrome related issues in Ireland. An inherited predisposition to certain types of cancer e.g. colon and endometrial.
Reposted by Lynch Syndrome Ireland
📣Missed #CGAIGC25 this year?
Catch the short discussion between Prof Sir John Burn & @swatipatelmd.bsky.social sharing long-awaited CaPP3 results, a follow-up to the landmark CaPP2 trial showing aspirin’s 💊role in lowering cancer risk in #LynchSyndrome
👉 tinyurl.com/msshdb5b
#HereditaryGICancer
Catch the short discussion between Prof Sir John Burn & @swatipatelmd.bsky.social sharing long-awaited CaPP3 results, a follow-up to the landmark CaPP2 trial showing aspirin’s 💊role in lowering cancer risk in #LynchSyndrome
👉 tinyurl.com/msshdb5b
#HereditaryGICancer
Baby Aspirin and Cancer Prevention in Lynch Syndrome: New CaPP3 Results
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
tinyurl.com
October 13, 2025 at 5:21 PM
📣Missed #CGAIGC25 this year?
Catch the short discussion between Prof Sir John Burn & @swatipatelmd.bsky.social sharing long-awaited CaPP3 results, a follow-up to the landmark CaPP2 trial showing aspirin’s 💊role in lowering cancer risk in #LynchSyndrome
👉 tinyurl.com/msshdb5b
#HereditaryGICancer
Catch the short discussion between Prof Sir John Burn & @swatipatelmd.bsky.social sharing long-awaited CaPP3 results, a follow-up to the landmark CaPP2 trial showing aspirin’s 💊role in lowering cancer risk in #LynchSyndrome
👉 tinyurl.com/msshdb5b
#HereditaryGICancer
Reposted by Lynch Syndrome Ireland
🧬 October = National Family History Month!
Read the blog📜👉 tinyurl.com/bdhjjv83
Reminding us that even in the era of🧬testing, 👪history is still the foundation of hereditary cancer care. Asking the right❓& sharing results can save lives across generations.
#HereditaryGICancer
Read the blog📜👉 tinyurl.com/bdhjjv83
Reminding us that even in the era of🧬testing, 👪history is still the foundation of hereditary cancer care. Asking the right❓& sharing results can save lives across generations.
#HereditaryGICancer
National Family History Month: A Reminder for Providers and Genetic Counselors!
October’s National Family History Month is an important opportunity to emphasize how family history drives cancer risk assessment, genetic referrals, and prevention. Even with growing access to geneti...
tinyurl.com
October 22, 2025 at 11:18 AM
🧬 October = National Family History Month!
Read the blog📜👉 tinyurl.com/bdhjjv83
Reminding us that even in the era of🧬testing, 👪history is still the foundation of hereditary cancer care. Asking the right❓& sharing results can save lives across generations.
#HereditaryGICancer
Read the blog📜👉 tinyurl.com/bdhjjv83
Reminding us that even in the era of🧬testing, 👪history is still the foundation of hereditary cancer care. Asking the right❓& sharing results can save lives across generations.
#HereditaryGICancer
Reposted by Lynch Syndrome Ireland
Day 3 of Hereditary Cancer Awareness Month 🧬 also highlights Gynecologic Cancer Awareness Month 💜.
Watch the video on ctDNA for Endometrial Cancer 🎥 tinyurl.com/3fajahme + listen to our podcast on Lynch syndrome & NCCN updates 🎧 tinyurl.com/2jmvmt7t
#HereditaryGICancer #LynchSyndrome
Watch the video on ctDNA for Endometrial Cancer 🎥 tinyurl.com/3fajahme + listen to our podcast on Lynch syndrome & NCCN updates 🎧 tinyurl.com/2jmvmt7t
#HereditaryGICancer #LynchSyndrome
September 30, 2025 at 11:19 AM
Day 3 of Hereditary Cancer Awareness Month 🧬 also highlights Gynecologic Cancer Awareness Month 💜.
Watch the video on ctDNA for Endometrial Cancer 🎥 tinyurl.com/3fajahme + listen to our podcast on Lynch syndrome & NCCN updates 🎧 tinyurl.com/2jmvmt7t
#HereditaryGICancer #LynchSyndrome
Watch the video on ctDNA for Endometrial Cancer 🎥 tinyurl.com/3fajahme + listen to our podcast on Lynch syndrome & NCCN updates 🎧 tinyurl.com/2jmvmt7t
#HereditaryGICancer #LynchSyndrome
Reposted by Lynch Syndrome Ireland
I have been able to connect with other people with Lynch Syndrome, and this has helped me so much, as I felt so alone when I was first diagnosed in 2024.
October 9, 2025 at 2:46 AM
I have been able to connect with other people with Lynch Syndrome, and this has helped me so much, as I felt so alone when I was first diagnosed in 2024.
Reposted by Lynch Syndrome Ireland
While the underlying genetic defects differ significantly between Lynch syndrome and FAP, the pathogenetic mechanisms in these two disorders represent canonical pathways of young-onset colorectal cancer carcinogenesis.
https://www.nature.c...
https://www.nature.c...
October 15, 2025 at 9:27 PM
While the underlying genetic defects differ significantly between Lynch syndrome and FAP, the pathogenetic mechanisms in these two disorders represent canonical pathways of young-onset colorectal cancer carcinogenesis.
https://www.nature.c...
https://www.nature.c...
Reposted by Lynch Syndrome Ireland
Back to London early as today’s my date for ongoing Lynch Syndrome bowel/prostate cancer research project at Royal Marsden. I don’t have the genetic flaw so am part of the control group. Important stuff x
October 9, 2025 at 9:17 AM
Back to London early as today’s my date for ongoing Lynch Syndrome bowel/prostate cancer research project at Royal Marsden. I don’t have the genetic flaw so am part of the control group. Important stuff x
Reposted by Lynch Syndrome Ireland
Frank Sinicrope MD of Mayo Clinic Comprehensive Cancer Center will present new subgroup findings from the #ATOMIC trial (Alliance A021502) in a poster session at #ESMO25. Data highlight outcomes in sporadic vs. Lynch syndrome–related dMMR colon cancer. Sunday, Oct 19. @ALLIANCE_org #NCI #NCTN #CRCsm
October 18, 2025 at 6:00 PM
Frank Sinicrope MD of Mayo Clinic Comprehensive Cancer Center will present new subgroup findings from the #ATOMIC trial (Alliance A021502) in a poster session at #ESMO25. Data highlight outcomes in sporadic vs. Lynch syndrome–related dMMR colon cancer. Sunday, Oct 19. @ALLIANCE_org #NCI #NCTN #CRCsm
Reposted by Lynch Syndrome Ireland
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JCO Oncology Practice ascopubs.org/doi/10.1200/...
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JCO Oncology Practice
ascopubs.org
October 11, 2025 at 8:23 AM
Critical Evaluation of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer | JCO Oncology Practice ascopubs.org/doi/10.1200/...
Reposted by Lynch Syndrome Ireland
New study shows COVID vaccines:
💉Reduced people’s risk of ER by 29%
💉Reduced risk of hospitalizations by 39%
💉Reduced the risk of death by 64%
💉Vaccination was effective in all age groups and “in persons with or without major chronic conditions.”
www.scientificamerican.com/article/new-...
💉Reduced people’s risk of ER by 29%
💉Reduced risk of hospitalizations by 39%
💉Reduced the risk of death by 64%
💉Vaccination was effective in all age groups and “in persons with or without major chronic conditions.”
www.scientificamerican.com/article/new-...
Annual COVID Vaccines Save Lives, New Study Shows
A new study shows that receiving an updated COVID vaccine reduced people’s risk of severe disease and death in all age groups, regardless of immunity from prior infection or vaccination
www.scientificamerican.com
October 10, 2025 at 4:05 AM
New study shows COVID vaccines:
💉Reduced people’s risk of ER by 29%
💉Reduced risk of hospitalizations by 39%
💉Reduced the risk of death by 64%
💉Vaccination was effective in all age groups and “in persons with or without major chronic conditions.”
www.scientificamerican.com/article/new-...
💉Reduced people’s risk of ER by 29%
💉Reduced risk of hospitalizations by 39%
💉Reduced the risk of death by 64%
💉Vaccination was effective in all age groups and “in persons with or without major chronic conditions.”
www.scientificamerican.com/article/new-...
Reposted by Lynch Syndrome Ireland
Excellent op Ed about the issues with single vaccines published in response to Trumps Statement about single shots for Measles, mumps and rubella as well as CDC call for single vaccine manufacturer 🧵🧪#HealthPolicy
CIDRAP Op-Ed: Why the CDC director is wrong about the MMR vaccine
www.cidrap.umn.edu
October 10, 2025 at 7:43 AM
Excellent op Ed about the issues with single vaccines published in response to Trumps Statement about single shots for Measles, mumps and rubella as well as CDC call for single vaccine manufacturer 🧵🧪#HealthPolicy
Reposted by Lynch Syndrome Ireland
Join our free, open access webinar with the Young European Hematology Association & @yefis-immunology.bsky.social, featuring 3 presentations on CAR T-cells!
📅 19 November 14:00-15:30 CET
🌍 Zoom
us02web.zoom.us/webinar/regi...
📅 19 November 14:00-15:30 CET
🌍 Zoom
us02web.zoom.us/webinar/regi...
October 10, 2025 at 8:01 AM
Join our free, open access webinar with the Young European Hematology Association & @yefis-immunology.bsky.social, featuring 3 presentations on CAR T-cells!
📅 19 November 14:00-15:30 CET
🌍 Zoom
us02web.zoom.us/webinar/regi...
📅 19 November 14:00-15:30 CET
🌍 Zoom
us02web.zoom.us/webinar/regi...
Reposted by Lynch Syndrome Ireland
🚨 It’s here!
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines
#InSiGHT2026 #HereditaryCancer #GICancerResearch
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines
#InSiGHT2026 #HereditaryCancer #GICancerResearch
September 19, 2025 at 1:18 PM
🚨 It’s here!
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines
#InSiGHT2026 #HereditaryCancer #GICancerResearch
The Scientific Program for InSiGHT 2026 (4–7 March, Singapore 🇸🇬) is now live!
🔗 Check out the full program: insight2026.org/scientific-programme
🧬 Abstracts due 30 Sept – submit yours: insight2026.org/abstract-submission-guidelines
#InSiGHT2026 #HereditaryCancer #GICancerResearch
Reposted by Lynch Syndrome Ireland
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
October 2, 2025 at 11:37 PM
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
Reposted by Lynch Syndrome Ireland
Mary Kennedy's powerful story about bowel screening inspired thousands of others to take action.
Her message is simple: even if you feel well, screening can save your life.
Read how her story made an impact: tinyurl.com/PPP-story-ca...
#ChooseScreening #BowelScreen
Her message is simple: even if you feel well, screening can save your life.
Read how her story made an impact: tinyurl.com/PPP-story-ca...
#ChooseScreening #BowelScreen
Shouting from the rooftops: how a powerful patient story about bowel screening inspired others to take action
A social media campaign highlighting the power of co-designing with our screening participants to share human stories.
tinyurl.com
October 7, 2025 at 2:20 PM
Mary Kennedy's powerful story about bowel screening inspired thousands of others to take action.
Her message is simple: even if you feel well, screening can save your life.
Read how her story made an impact: tinyurl.com/PPP-story-ca...
#ChooseScreening #BowelScreen
Her message is simple: even if you feel well, screening can save your life.
Read how her story made an impact: tinyurl.com/PPP-story-ca...
#ChooseScreening #BowelScreen
Reposted by Lynch Syndrome Ireland
Today, we launch #CancerNeedsTrials.
Cancer trials give patients access to tomorrow’s treatments today — but in Ireland, access is too limited.
We’re calling on the government to invest so more patients can benefit. Add your voice: bit.ly/4nos5iL
#CancerNeedsTrials
Cancer trials give patients access to tomorrow’s treatments today — but in Ireland, access is too limited.
We’re calling on the government to invest so more patients can benefit. Add your voice: bit.ly/4nos5iL
#CancerNeedsTrials
September 30, 2025 at 8:30 AM
Today, we launch #CancerNeedsTrials.
Cancer trials give patients access to tomorrow’s treatments today — but in Ireland, access is too limited.
We’re calling on the government to invest so more patients can benefit. Add your voice: bit.ly/4nos5iL
#CancerNeedsTrials
Cancer trials give patients access to tomorrow’s treatments today — but in Ireland, access is too limited.
We’re calling on the government to invest so more patients can benefit. Add your voice: bit.ly/4nos5iL
#CancerNeedsTrials
Reposted by Lynch Syndrome Ireland
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
September 27, 2025 at 2:40 PM
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Lynch Syndrome Ireland
Genetic testing appears to have limited utility in SPS patients and may primarily identify those with an incidental diagnosis of Lynch syndrome
pubmed.ncbi.nlm.nih.gov/41002021/
pubmed.ncbi.nlm.nih.gov/41002021/
Low Yield of Genetic Testing in Serrated Polyposis Syndrome - PubMed
Genetic testing demonstrated a low diagnostic yield in this SPS cohort, suggesting undefined genetic risk or involvement of other pathophysiological factors. Therefore, genetic testing appears to have...
pubmed.ncbi.nlm.nih.gov
September 27, 2025 at 12:10 PM
Genetic testing appears to have limited utility in SPS patients and may primarily identify those with an incidental diagnosis of Lynch syndrome
pubmed.ncbi.nlm.nih.gov/41002021/
pubmed.ncbi.nlm.nih.gov/41002021/
Reposted by Lynch Syndrome Ireland
Reposted by Lynch Syndrome Ireland
So the politicisation of health continues in the States and I want to highlight a few key things 🧪🧵
Trump attacks Tylenol as officials unveil highly contentious conclusions on autism
President says acetaminophen – also known as paracetamol - increases risk when taken by pregnant women, assertion contradicted by research
www.theguardian.com
September 23, 2025 at 7:22 AM
So the politicisation of health continues in the States and I want to highlight a few key things 🧪🧵
Reposted by Lynch Syndrome Ireland
Doing Cancer Wrong:
I have an innate tendency to do precisely the opposite of what society expects from me.
adventuresofasickdoctor.blogspot.com/2025/06/doin...
I have an innate tendency to do precisely the opposite of what society expects from me.
adventuresofasickdoctor.blogspot.com/2025/06/doin...
Doing Cancer Wrong
doctor cancer blog
adventuresofasickdoctor.blogspot.com
June 17, 2025 at 2:01 PM
Doing Cancer Wrong:
I have an innate tendency to do precisely the opposite of what society expects from me.
adventuresofasickdoctor.blogspot.com/2025/06/doin...
I have an innate tendency to do precisely the opposite of what society expects from me.
adventuresofasickdoctor.blogspot.com/2025/06/doin...
Reposted by Lynch Syndrome Ireland
Fantastic piece in Nature Reviews Neuro by @nicolecrust.bsky.social on the importance of science communication. My take? Everything matters - just do something. It will make a difference for how science is valued and trusted, how community understands. Let's get out there and communicate! 👏
The unexpected value of communicating science to the public
Nature Reviews Neuroscience - As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much...
rdcu.be
September 18, 2025 at 5:01 PM
Fantastic piece in Nature Reviews Neuro by @nicolecrust.bsky.social on the importance of science communication. My take? Everything matters - just do something. It will make a difference for how science is valued and trusted, how community understands. Let's get out there and communicate! 👏
Reposted by Lynch Syndrome Ireland
Endometriosis is a chronic inflammatory disease in which cells similar to those lining the uterus are present outside of the uterus.
This JAMA Patient Page describes endometriosis development, as well as its signs and symptoms, diagnosis, and treatment.
ja.ma/3K53fpL
This JAMA Patient Page describes endometriosis development, as well as its signs and symptoms, diagnosis, and treatment.
ja.ma/3K53fpL
September 18, 2025 at 3:30 PM
Endometriosis is a chronic inflammatory disease in which cells similar to those lining the uterus are present outside of the uterus.
This JAMA Patient Page describes endometriosis development, as well as its signs and symptoms, diagnosis, and treatment.
ja.ma/3K53fpL
This JAMA Patient Page describes endometriosis development, as well as its signs and symptoms, diagnosis, and treatment.
ja.ma/3K53fpL
