loscharlos
@loscharlos.bsky.social
😎🌁🎷 #LongCovid March 2020 😵💫
Reposted by loscharlos
To learn more, visit our landing page:
longcovid.scripps.edu/locitt-t/?ut...
Read the op-ed I wrote about this study & the need for at-home trials in The Sick TImes:
thesicktimes.org/2025/10/30/w...
Read our press release:
www.scripps.edu/news-and-eve...
grateful & hopeful,
JMV
16/16
longcovid.scripps.edu/locitt-t/?ut...
Read the op-ed I wrote about this study & the need for at-home trials in The Sick TImes:
thesicktimes.org/2025/10/30/w...
Read our press release:
www.scripps.edu/news-and-eve...
grateful & hopeful,
JMV
16/16
LoCITT-T - Long COVID Treatment Trial
longcovid.scripps.edu
October 30, 2025 at 6:24 PM
To learn more, visit our landing page:
longcovid.scripps.edu/locitt-t/?ut...
Read the op-ed I wrote about this study & the need for at-home trials in The Sick TImes:
thesicktimes.org/2025/10/30/w...
Read our press release:
www.scripps.edu/news-and-eve...
grateful & hopeful,
JMV
16/16
longcovid.scripps.edu/locitt-t/?ut...
Read the op-ed I wrote about this study & the need for at-home trials in The Sick TImes:
thesicktimes.org/2025/10/30/w...
Read our press release:
www.scripps.edu/news-and-eve...
grateful & hopeful,
JMV
16/16
Reposted by loscharlos
my wonderful colleagues who conquered all the setbacks we encountered (especially @erictopol.bsky.social who I am co-leading the trial with),
our knowledgeable data safety monitoring board members,
and most of all the participants who decide to spend their precious energy on this trial.
15/16
our knowledgeable data safety monitoring board members,
and most of all the participants who decide to spend their precious energy on this trial.
15/16
October 30, 2025 at 6:24 PM
my wonderful colleagues who conquered all the setbacks we encountered (especially @erictopol.bsky.social who I am co-leading the trial with),
our knowledgeable data safety monitoring board members,
and most of all the participants who decide to spend their precious energy on this trial.
15/16
our knowledgeable data safety monitoring board members,
and most of all the participants who decide to spend their precious energy on this trial.
15/16
Reposted by loscharlos
I want to thank more people than I can count:
Every patient-researcher who came before me,
everyone who helped me learn about LC and other IACCs,
our collaborators (especially the Schmidt Initiative for LC who provided study funding & Eli Lilly who is providing study drug & distribution),
14/16
Every patient-researcher who came before me,
everyone who helped me learn about LC and other IACCs,
our collaborators (especially the Schmidt Initiative for LC who provided study funding & Eli Lilly who is providing study drug & distribution),
14/16
October 30, 2025 at 6:24 PM
I want to thank more people than I can count:
Every patient-researcher who came before me,
everyone who helped me learn about LC and other IACCs,
our collaborators (especially the Schmidt Initiative for LC who provided study funding & Eli Lilly who is providing study drug & distribution),
14/16
Every patient-researcher who came before me,
everyone who helped me learn about LC and other IACCs,
our collaborators (especially the Schmidt Initiative for LC who provided study funding & Eli Lilly who is providing study drug & distribution),
14/16
Reposted by loscharlos
The faster we enroll 1,000 participants, the faster we can share results.
Please consider sharing this with your network, especially people with LC who are less likely to hear about it online.
It is crucial to represent the breadth LC, especially across demographics & illness severities.
13/16
Please consider sharing this with your network, especially people with LC who are less likely to hear about it online.
It is crucial to represent the breadth LC, especially across demographics & illness severities.
13/16
October 30, 2025 at 6:24 PM
The faster we enroll 1,000 participants, the faster we can share results.
Please consider sharing this with your network, especially people with LC who are less likely to hear about it online.
It is crucial to represent the breadth LC, especially across demographics & illness severities.
13/16
Please consider sharing this with your network, especially people with LC who are less likely to hear about it online.
It is crucial to represent the breadth LC, especially across demographics & illness severities.
13/16
Reposted by loscharlos
We have been working with @careevolution.com to create a platform for remote clinical trials that allows participants across the US to participate from wherever they are.
There are many drugs we would like to test & we are pursuing the funding to support more trials.
12/16
There are many drugs we would like to test & we are pursuing the funding to support more trials.
12/16
October 30, 2025 at 6:24 PM
We have been working with @careevolution.com to create a platform for remote clinical trials that allows participants across the US to participate from wherever they are.
There are many drugs we would like to test & we are pursuing the funding to support more trials.
12/16
There are many drugs we would like to test & we are pursuing the funding to support more trials.
12/16
Reposted by loscharlos
We expect there to be varied responses within people with Long COVID and have aimed to power the trial accordingly by enrolling a large number of participants & asking a lot of questions that will allow us to analyze subgroups of participants.
11/16
11/16
October 30, 2025 at 6:24 PM
We expect there to be varied responses within people with Long COVID and have aimed to power the trial accordingly by enrolling a large number of participants & asking a lot of questions that will allow us to analyze subgroups of participants.
11/16
11/16
Reposted by loscharlos
It’s important to me that we make the trial as accessible as possible, to include people who have not been invited to participate in the past whether that’s due to their race, location, and/or illness severity.
10/16
10/16
October 30, 2025 at 6:24 PM
It’s important to me that we make the trial as accessible as possible, to include people who have not been invited to participate in the past whether that’s due to their race, location, and/or illness severity.
10/16
10/16
Reposted by loscharlos
even if it doesn’t, we will learn about how it affects Long COVID fatigue, rates of side effects, & more about how to operate a nationwide, remote trial, helping people with Long COVID administer an injectable drug.
While I don’t expect this to cure Long COVID, I hope it decreases suffering.
9/16
While I don’t expect this to cure Long COVID, I hope it decreases suffering.
9/16
October 30, 2025 at 6:24 PM
even if it doesn’t, we will learn about how it affects Long COVID fatigue, rates of side effects, & more about how to operate a nationwide, remote trial, helping people with Long COVID administer an injectable drug.
While I don’t expect this to cure Long COVID, I hope it decreases suffering.
9/16
While I don’t expect this to cure Long COVID, I hope it decreases suffering.
9/16
Reposted by loscharlos
Recent studies on GLP-1 drugs, including tirzepatide, & anecdotal reports, have been promising.
An RCT is needed to generate high-quality data describing its effects in this population and move toward insurance coverage.
While I hope the trial demonstrates that tirzepatide decreases fatigue,
8/16
An RCT is needed to generate high-quality data describing its effects in this population and move toward insurance coverage.
While I hope the trial demonstrates that tirzepatide decreases fatigue,
8/16
October 30, 2025 at 6:24 PM
Recent studies on GLP-1 drugs, including tirzepatide, & anecdotal reports, have been promising.
An RCT is needed to generate high-quality data describing its effects in this population and move toward insurance coverage.
While I hope the trial demonstrates that tirzepatide decreases fatigue,
8/16
An RCT is needed to generate high-quality data describing its effects in this population and move toward insurance coverage.
While I hope the trial demonstrates that tirzepatide decreases fatigue,
8/16
Reposted by loscharlos
Also this trial was restricted to Long COVID, but if it is successful, we will aim to expand to other infection-associated chronic conditions, including ME.
7/16
7/16
October 30, 2025 at 6:24 PM
Also this trial was restricted to Long COVID, but if it is successful, we will aim to expand to other infection-associated chronic conditions, including ME.
7/16
7/16
Reposted by loscharlos
For example, we will add more states as soon as we can.
If you’re interested and live in another state in the US, please sign up for the waitlist.
We’ll reach out to you when your state is open for enrollment:
mydatahelps.org/e/LOCITT/Wai...
6/16
If you’re interested and live in another state in the US, please sign up for the waitlist.
We’ll reach out to you when your state is open for enrollment:
mydatahelps.org/e/LOCITT/Wai...
6/16
Survey -
MyDataHelps
mydatahelps.org
October 30, 2025 at 6:24 PM
For example, we will add more states as soon as we can.
If you’re interested and live in another state in the US, please sign up for the waitlist.
We’ll reach out to you when your state is open for enrollment:
mydatahelps.org/e/LOCITT/Wai...
6/16
If you’re interested and live in another state in the US, please sign up for the waitlist.
We’ll reach out to you when your state is open for enrollment:
mydatahelps.org/e/LOCITT/Wai...
6/16
Reposted by loscharlos
... by having people who require this accommodation test the experience.
It has taken a lot of thought & care to get to this point, with difficult tradeoffs along the way.
I am confident we’ve done our best within the constraints we had, & that we’ll improve as we learn from participants.
5/16
It has taken a lot of thought & care to get to this point, with difficult tradeoffs along the way.
I am confident we’ve done our best within the constraints we had, & that we’ll improve as we learn from participants.
5/16
October 30, 2025 at 6:24 PM
... by having people who require this accommodation test the experience.
It has taken a lot of thought & care to get to this point, with difficult tradeoffs along the way.
I am confident we’ve done our best within the constraints we had, & that we’ll improve as we learn from participants.
5/16
It has taken a lot of thought & care to get to this point, with difficult tradeoffs along the way.
I am confident we’ve done our best within the constraints we had, & that we’ll improve as we learn from participants.
5/16
Reposted by loscharlos
while including secondary endpoints (FUNCAP & metrics like step count from wearables) that we expect to be more sensitive & can use this trial to generate data about.
We’ve made sure that the trial is accessible to people who are unable to verbally speak due to the severity of their illness,
4/16
We’ve made sure that the trial is accessible to people who are unable to verbally speak due to the severity of their illness,
4/16
October 30, 2025 at 6:24 PM
while including secondary endpoints (FUNCAP & metrics like step count from wearables) that we expect to be more sensitive & can use this trial to generate data about.
We’ve made sure that the trial is accessible to people who are unable to verbally speak due to the severity of their illness,
4/16
We’ve made sure that the trial is accessible to people who are unable to verbally speak due to the severity of their illness,
4/16
Reposted by loscharlos
The input from many different people with lived experience about what existing endpoints are sensitive enough to changes in symptom severity helped us land on a primary endpoint (Fatigue Severity Scale) that was acceptable to FDA and is relatively sensitive to changes in illness severity ...
3/16
3/16
October 30, 2025 at 6:24 PM
The input from many different people with lived experience about what existing endpoints are sensitive enough to changes in symptom severity helped us land on a primary endpoint (Fatigue Severity Scale) that was acceptable to FDA and is relatively sensitive to changes in illness severity ...
3/16
3/16
Reposted by loscharlos
LoCITT-T is a 1,000-person double-blind, randomized, placebo-controlled trial.
This trial has been designed in partnership with patients (not just me!) throughout.
For example, most Long COVID clinical trials that have released results have not resulted in the improvement they hoped for...
2/16
This trial has been designed in partnership with patients (not just me!) throughout.
For example, most Long COVID clinical trials that have released results have not resulted in the improvement they hoped for...
2/16
October 30, 2025 at 6:24 PM
LoCITT-T is a 1,000-person double-blind, randomized, placebo-controlled trial.
This trial has been designed in partnership with patients (not just me!) throughout.
For example, most Long COVID clinical trials that have released results have not resulted in the improvement they hoped for...
2/16
This trial has been designed in partnership with patients (not just me!) throughout.
For example, most Long COVID clinical trials that have released results have not resulted in the improvement they hoped for...
2/16
Reposted by loscharlos
The Long COVID Treatment Trial – Tirzepatide (LoCITT-T) is officially open for enrollment for people with Long COVID in:
Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah
longcovid.scripps.edu/locitt-t/?ut...
1/16
Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah
longcovid.scripps.edu/locitt-t/?ut...
1/16
LoCITT-T - Long COVID Treatment Trial
longcovid.scripps.edu
October 30, 2025 at 6:24 PM
The Long COVID Treatment Trial – Tirzepatide (LoCITT-T) is officially open for enrollment for people with Long COVID in:
Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah
longcovid.scripps.edu/locitt-t/?ut...
1/16
Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah
longcovid.scripps.edu/locitt-t/?ut...
1/16
Reposted by loscharlos
Since I'm following this...Porzingis played 26 minutes Wednesday in his team's season opener. Tonight the Hawks said he will not play due to "flu-like" symptoms.
This is very suggestive to me that he is experiencing post-exertional malaise, a hallmark of many cases of long COVID and the central […]
This is very suggestive to me that he is experiencing post-exertional malaise, a hallmark of many cases of long COVID and the central […]
Original post on mas.to
mas.to
October 24, 2025 at 11:55 PM
Since I'm following this...Porzingis played 26 minutes Wednesday in his team's season opener. Tonight the Hawks said he will not play due to "flu-like" symptoms.
This is very suggestive to me that he is experiencing post-exertional malaise, a hallmark of many cases of long COVID and the central […]
This is very suggestive to me that he is experiencing post-exertional malaise, a hallmark of many cases of long COVID and the central […]
Reposted by loscharlos
Millions of Americans suffer w/ Long Covid. They deserve a federal gov't that will have their back. 47's admin is not only failing to achieve those goals, but actively taking us in the wrong direction.
The numbers in kids are huge: as much as autism, as much as ADHD.
Free link: archive.ph/0CwNs
The numbers in kids are huge: as much as autism, as much as ADHD.
Free link: archive.ph/0CwNs
October 17, 2025 at 1:57 AM
Millions of Americans suffer w/ Long Covid. They deserve a federal gov't that will have their back. 47's admin is not only failing to achieve those goals, but actively taking us in the wrong direction.
The numbers in kids are huge: as much as autism, as much as ADHD.
Free link: archive.ph/0CwNs
The numbers in kids are huge: as much as autism, as much as ADHD.
Free link: archive.ph/0CwNs
Reposted by loscharlos
“In January 2024, a study published in the Proceedings of the National Academy of Sciences found that chronic absenteeism… nearly doubled following the Covid pandemic.”
“In total, nearly 30% — some 13 million children — regularly missed school.”
“In total, nearly 30% — some 13 million children — regularly missed school.”
October 16, 2025 at 5:14 PM
“In January 2024, a study published in the Proceedings of the National Academy of Sciences found that chronic absenteeism… nearly doubled following the Covid pandemic.”
“In total, nearly 30% — some 13 million children — regularly missed school.”
“In total, nearly 30% — some 13 million children — regularly missed school.”
Reposted by loscharlos
Most people aren’t asking you mask at all times.
They ask that you mask in essential places: public transit, hospitals, doctors’ offices, pharmacies etc.
Places high risk people can’t avoid.
But if you hate wearing masks? Then advocate for indoor air quality: ventilation, filtration, etc.
They ask that you mask in essential places: public transit, hospitals, doctors’ offices, pharmacies etc.
Places high risk people can’t avoid.
But if you hate wearing masks? Then advocate for indoor air quality: ventilation, filtration, etc.
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 14, 2025 at 4:37 PM
Most people aren’t asking you mask at all times.
They ask that you mask in essential places: public transit, hospitals, doctors’ offices, pharmacies etc.
Places high risk people can’t avoid.
But if you hate wearing masks? Then advocate for indoor air quality: ventilation, filtration, etc.
They ask that you mask in essential places: public transit, hospitals, doctors’ offices, pharmacies etc.
Places high risk people can’t avoid.
But if you hate wearing masks? Then advocate for indoor air quality: ventilation, filtration, etc.
Reposted by loscharlos
Does privilege do this to your brain? Folks are pretending that being asked to mask is the most oppressive thing to ever exist and I'd like to know why. Selfishness? Privilege? You weren't raised right? What is it? What about masking is "unreasonable"?
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 14, 2025 at 11:04 PM
Does privilege do this to your brain? Folks are pretending that being asked to mask is the most oppressive thing to ever exist and I'd like to know why. Selfishness? Privilege? You weren't raised right? What is it? What about masking is "unreasonable"?
Reposted by loscharlos
I’ve been masking at all times in public spaces since 2020 and it’s really not that difficult at all you just put the mask on and go tbh
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 14, 2025 at 11:58 PM
I’ve been masking at all times in public spaces since 2020 and it’s really not that difficult at all you just put the mask on and go tbh
Reposted by loscharlos
Masking at ublic transit, hospitals, pharmacies, and the grocery store would be absolutely fantastic for public health tbh.
Improved ventilation could mitigate the need for even that much but at this rate, we will never know for sure.
Improved ventilation could mitigate the need for even that much but at this rate, we will never know for sure.
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 15, 2025 at 12:23 AM
Masking at ublic transit, hospitals, pharmacies, and the grocery store would be absolutely fantastic for public health tbh.
Improved ventilation could mitigate the need for even that much but at this rate, we will never know for sure.
Improved ventilation could mitigate the need for even that much but at this rate, we will never know for sure.
Reposted by loscharlos
Oh baby do I have some news for yall. You better get comfy with that mask sooner rather than later.
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 15, 2025 at 2:56 AM
Oh baby do I have some news for yall. You better get comfy with that mask sooner rather than later.
Reposted by loscharlos
40%+ of Covid cases are asymptomatic. I guarantee if you don't care to mask you do not care to test yourself systematically either....
yeah, i think a commitment to public health obligates you to get vaccinated and, when you are sick, do what you can to avoid spreading that to other people. the demand that one mask at all times in public spaces is, i think, unreasonable.
October 15, 2025 at 3:02 AM
40%+ of Covid cases are asymptomatic. I guarantee if you don't care to mask you do not care to test yourself systematically either....