Loïc Guillot
@loicguillot.bsky.social
Lung diseases 🫁 innate immunity and 🧬 Inserm research director
St-Antoine Research Center, Paris, France
https://sites.google.com/view/loic-guillots-group-cf/home
St-Antoine Research Center, Paris, France
https://sites.google.com/view/loic-guillots-group-cf/home
👏 J. Bigot & V. Balloy @CRSA-paris.bsky.social @sorbonne-universite.fr @hopital-stantoine.bsky.social, R. Legendre & C. Chica @Pasteur.fr + team
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
Genes & Immunity - The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
rdcu.be
September 24, 2025 at 2:45 PM
👏 J. Bigot & V. Balloy @CRSA-paris.bsky.social @sorbonne-universite.fr @hopital-stantoine.bsky.social, R. Legendre & C. Chica @Pasteur.fr + team
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY
Our last study about #aspergillus ABPA in #cysticfibrosis: Case-control study from the French registry academic.oup.com/mmy/article/...
@crsa-paris.bsky.social @inserm.fr @fac-sante-sorbonne.bsky.social thanks @vaincrelamuco.bsky.social for funding 🙏
@crsa-paris.bsky.social @inserm.fr @fac-sante-sorbonne.bsky.social thanks @vaincrelamuco.bsky.social for funding 🙏
Allergic bronchopulmonary aspergillosis in cystic fibrosis: Case-control study from the French registry
Abstract. Allergic bronchopulmonary aspergillosis (ABPA) is a significant complication in people with cystic fibrosis (pwCF), driven by hypersensitivity to
academic.oup.com
April 13, 2025 at 5:12 PM
Our last study about #aspergillus ABPA in #cysticfibrosis: Case-control study from the French registry academic.oup.com/mmy/article/...
@crsa-paris.bsky.social @inserm.fr @fac-sante-sorbonne.bsky.social thanks @vaincrelamuco.bsky.social for funding 🙏
@crsa-paris.bsky.social @inserm.fr @fac-sante-sorbonne.bsky.social thanks @vaincrelamuco.bsky.social for funding 🙏
Reposted by Loïc Guillot
Our proposed #coverart for a new study in @cp-iscience.bsky.social, from the labs of @loicguillot.bsky.social ky.social and @olivierterrier.bsky.social 🧪
📖 Full paper: lnkd.in/dSfrd8Z5
#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm
📖 Full paper: lnkd.in/dSfrd8Z5
#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm
April 3, 2025 at 1:15 PM
Our proposed #coverart for a new study in @cp-iscience.bsky.social, from the labs of @loicguillot.bsky.social ky.social and @olivierterrier.bsky.social 🧪
📖 Full paper: lnkd.in/dSfrd8Z5
#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm
📖 Full paper: lnkd.in/dSfrd8Z5
#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm
Reposted by Loïc Guillot
A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 7:52 PM
A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Loïc Guillot
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
March 6, 2025 at 12:00 AM
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Glad to share our work about SARS-COV-2 epithelial response according to pathological origin #CF #COPD with @olivierterrier.bsky.social Simon Rousseau @mcgill.ca & co! Grateful for the support from @sorbonne-universite.fr & Air Liquide foundation. @cnrs.fr @inserm.fr www.cell.com/iscience/ful...
Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases
Pre-existing respiratory diseases may influence coronavirus disease (COVID-19) susceptibility
and severity. However, the molecular mechanisms underlying the airway epithelial response
to severe acute ...
www.cell.com
February 12, 2025 at 12:34 PM
Glad to share our work about SARS-COV-2 epithelial response according to pathological origin #CF #COPD with @olivierterrier.bsky.social Simon Rousseau @mcgill.ca & co! Grateful for the support from @sorbonne-universite.fr & Air Liquide foundation. @cnrs.fr @inserm.fr www.cell.com/iscience/ful...
Great to share our last collaborative work on trained immunity in bronchial cells. Bravo Jeanne Bigot @crsa-paris.bsky.social @sorbonne-universite.fr Rachel Legendre @pasteur.fr 🧪
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity https://www.biorxiv.org/content/10.1101/2025.02.03.636250v1
February 11, 2025 at 3:07 PM
Great to share our last collaborative work on trained immunity in bronchial cells. Bravo Jeanne Bigot @crsa-paris.bsky.social @sorbonne-universite.fr Rachel Legendre @pasteur.fr 🧪
Reposted by Loïc Guillot
New online! Fungal biofilms in human health and disease
Fungal biofilms in human health and disease
Nature Reviews Microbiology, Published online: 05 February 2025; doi:10.1038/s41579-025-01147-0Fungal biofilms encompass a wide range of diseases with increasing clinical impact. In this Review, Ramage et al. discuss the clinical importance of fungal…
www.nature.com
February 5, 2025 at 4:59 PM
New online! Fungal biofilms in human health and disease
Reposted by Loïc Guillot
Le CRSA change de tête: Félicitations à @loicguillot.bsky.social et Xavier Houard, nos nouveaux directeurs !
January 27, 2025 at 4:56 PM
Le CRSA change de tête: Félicitations à @loicguillot.bsky.social et Xavier Houard, nos nouveaux directeurs !
Reposted by Loïc Guillot
Widespread use of azole fungicides in agriculture may reduce the effectiveness of antifungal treatments for patients with aspergillosis. EMA highlights that nearly all 120,000 tonnes of azoles sold in the EU were used as pesticides, potentially contributing to #AMR
www.ema.europa.eu/en/news/one-...
www.ema.europa.eu/en/news/one-...
One Health: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi | European Medicines Agency (EMA)
The extensive use of azole fungicides (azoles), particularly in some agricultural and horticultural practices, can increase the risk of Aspergillus fungi developing resistance to essential antifungal ...
www.ema.europa.eu
January 31, 2025 at 9:26 AM
Widespread use of azole fungicides in agriculture may reduce the effectiveness of antifungal treatments for patients with aspergillosis. EMA highlights that nearly all 120,000 tonnes of azoles sold in the EU were used as pesticides, potentially contributing to #AMR
www.ema.europa.eu/en/news/one-...
www.ema.europa.eu/en/news/one-...
Reposted by Loïc Guillot
Job alert! post-doctoral position on #macrophages biology to study the role of a post-translational modification in inflammation and ROS production with Tarik Issad's team @institutcochin.bsky.social in #Paris! Please apply on the @cnrs.bsky.social website: emploi.cnrs.fr/Offres/CDD/U...
January 29, 2025 at 11:06 PM
Job alert! post-doctoral position on #macrophages biology to study the role of a post-translational modification in inflammation and ROS production with Tarik Issad's team @institutcochin.bsky.social in #Paris! Please apply on the @cnrs.bsky.social website: emploi.cnrs.fr/Offres/CDD/U...
Reposted by Loïc Guillot
#MedSky🧪 #IDsky #publichealth @thelancet.bsky.social Multidrug resistant Gram-ve bacterial infections cause significant morbidity & mortality globally. A new diagnostic & antibiotic Tx provide hope that we can better address this important #globalhealth issue.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 18, 2025 at 5:52 PM
#MedSky🧪 #IDsky #publichealth @thelancet.bsky.social Multidrug resistant Gram-ve bacterial infections cause significant morbidity & mortality globally. A new diagnostic & antibiotic Tx provide hope that we can better address this important #globalhealth issue.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Loïc Guillot
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
www.science.org
December 6, 2024 at 10:38 PM
🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Loïc Guillot
Harnessing neutrophils to enhance efficacy of host-directed therapy in pneumococcal pneumonia: www.mucosalimmunology.org/article/S193...
December 4, 2024 at 6:45 PM
Harnessing neutrophils to enhance efficacy of host-directed therapy in pneumococcal pneumonia: www.mucosalimmunology.org/article/S193...
Reposted by Loïc Guillot
Does calorie labeling change food/energy consumption?
Not in this new open-access report
www.nature.com/articles/s41... @naturehumbehav.bsky.social
Not in this new open-access report
www.nature.com/articles/s41... @naturehumbehav.bsky.social
Evaluating the association between the introduction of mandatory calorie labelling and energy consumed using observational data from the out-of-home food sector in England - Nature Human Behaviour
The introduction of mandatory calorie labelling in out-of-home food outlets in England was not associated with a reduction in calories purchased or consumed. There was a post-policy increase in self-r...
www.nature.com
November 25, 2024 at 4:20 PM
Does calorie labeling change food/energy consumption?
Not in this new open-access report
www.nature.com/articles/s41... @naturehumbehav.bsky.social
Not in this new open-access report
www.nature.com/articles/s41... @naturehumbehav.bsky.social
Reposted by Loïc Guillot
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
November 19, 2024 at 12:27 PM
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
Reposted by Loïc Guillot
🆕 Few thoughts we wanted to share with the community to look at 🍄 #aspergillosis diagnosis from a different perspective when we are still struggling on the topic.
w/ @simonfeys.bsky.social @agocarvalho.bsky.social & cie
Actively working on more answers. Stay tuned.
👉 doi.org/10.1016/j.cm...
w/ @simonfeys.bsky.social @agocarvalho.bsky.social & cie
Actively working on more answers. Stay tuned.
👉 doi.org/10.1016/j.cm...
November 18, 2024 at 9:37 PM
🆕 Few thoughts we wanted to share with the community to look at 🍄 #aspergillosis diagnosis from a different perspective when we are still struggling on the topic.
w/ @simonfeys.bsky.social @agocarvalho.bsky.social & cie
Actively working on more answers. Stay tuned.
👉 doi.org/10.1016/j.cm...
w/ @simonfeys.bsky.social @agocarvalho.bsky.social & cie
Actively working on more answers. Stay tuned.
👉 doi.org/10.1016/j.cm...
Reposted by Loïc Guillot
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen: www.mucosalimmunology.org/article/S193...
November 20, 2024 at 4:50 PM
Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen: www.mucosalimmunology.org/article/S193...
Reposted by Loïc Guillot
Do you know an experienced immunologist who is interested in studying human #immune development with next-generation methods? My lab is #hiring! Great pay, job stability, and a great place to work! Please share widely talent.stjude.org/careers/jobs...
St. Jude Is Hiring | Join Our Mission | St. Jude Careers
Explore job opportunities at St. Jude Children’s Research Hospital. Career opportunities exist in the areas of science, clinical care, operations, and more!
talent.stjude.org
November 20, 2024 at 5:56 AM
Do you know an experienced immunologist who is interested in studying human #immune development with next-generation methods? My lab is #hiring! Great pay, job stability, and a great place to work! Please share widely talent.stjude.org/careers/jobs...
Reposted by Loïc Guillot
🦠🧬🧫 Reminder that mBio publishes review articles and perspectives. If you have an idea in any area of microbiology or infection immunology, message me. No publication charge. Support Amer Soc Micro rather than a for-profit publisher! 📑💰 journals.asm.org/journal/mbio...
mBio Formatting Information
Overview of types of content published in mBio
journals.asm.org
November 12, 2024 at 5:20 PM
🦠🧬🧫 Reminder that mBio publishes review articles and perspectives. If you have an idea in any area of microbiology or infection immunology, message me. No publication charge. Support Amer Soc Micro rather than a for-profit publisher! 📑💰 journals.asm.org/journal/mbio...