Reposted by Lingfei Wang
The Matthew Effect is alive and well in academia - always makes me wary of programs aimed at identifying rising stars in an already highly talented pool...
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
elifesciences.org
November 12, 2025 at 7:03 PM
The Matthew Effect is alive and well in academia - always makes me wary of programs aimed at identifying rising stars in an already highly talented pool...
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Lingfei Wang
Harvard PD looking for help identifying these people
November 2, 2025 at 1:48 AM
Harvard PD looking for help identifying these people
Reposted by Lingfei Wang
So what are the bottom lines?
First, a HUGE thank you to NIH staff (particularly grants management specialists but program officers and others as well) for getting this work done in a compressed period with many other stressors.
29/n
First, a HUGE thank you to NIH staff (particularly grants management specialists but program officers and others as well) for getting this work done in a compressed period with many other stressors.
29/n
a cartoon of a person making a heart with their hands and the words thank you so much
ALT: a cartoon of a person making a heart with their hands and the words thank you so much
media.tenor.com
October 1, 2025 at 4:08 PM
So what are the bottom lines?
First, a HUGE thank you to NIH staff (particularly grants management specialists but program officers and others as well) for getting this work done in a compressed period with many other stressors.
29/n
First, a HUGE thank you to NIH staff (particularly grants management specialists but program officers and others as well) for getting this work done in a compressed period with many other stressors.
29/n
Reposted by Lingfei Wang
Compelling and quite disturbing...
September 30, 2025 at 12:01 PM
Compelling and quite disturbing...
Reposted by Lingfei Wang
The type of speech most punished in this society is that which consists of telling the truth about how the powerful have harmed you
September 13, 2025 at 9:22 PM
The type of speech most punished in this society is that which consists of telling the truth about how the powerful have harmed you
Delighted to announce that our MIRA R35 has been awarded 5-year funding! We are looking for a postdoc for the #CausalInference of #ComplexNetworks among genes at academicjobsonline.org/ajo/jobs/30523. Very grateful to NIH GMS and program officers and study section panelists!
University of Massachusetts Chan Medical School, GRN Lab
Job #AJO30523, Postdoc in Causal Inference of Complex Gene Networks, GRN Lab, University of Massachusetts Chan Medical School, Worcester, Massachusetts, US
academicjobsonline.org
September 9, 2025 at 7:30 PM
Delighted to announce that our MIRA R35 has been awarded 5-year funding! We are looking for a postdoc for the #CausalInference of #ComplexNetworks among genes at academicjobsonline.org/ajo/jobs/30523. Very grateful to NIH GMS and program officers and study section panelists!
Also true for computational studies. Especially 1, if you take too many shortcuts, these technical debts will come back for you.
Very true. In my experience, there are three aspects of “good hands”. 1. Be low entropy: when in doubt, do things in an orderly manner. 2. Make good micro decisions: observe what matters and what doesn’t in any given protocol. 3. Make fewer errors. Of these, I think 2 is the most learnable.
Every few months the "good lab hands" thing comes up and it misses a key point: you can learn to have good hands. Training matters.
Good hands aren't some magic gift from the PCR gods, you have to develop them through directed repetitive practice, like any other skill
Good hands aren't some magic gift from the PCR gods, you have to develop them through directed repetitive practice, like any other skill
September 6, 2025 at 1:42 PM
Also true for computational studies. Especially 1, if you take too many shortcuts, these technical debts will come back for you.
Reposted by Lingfei Wang
The NIH Simplified Peer Review Framework and Preliminary Data drugmonkey.wordpress.com/2025/08/28/t...
The NIH Simplified Peer Review Framework and Preliminary Data
While pondering the impact of a unintended potential consequence of the new NIH approach to grant review (Simplified Peer Review Framework ), I thought of another likely impact. Removing the usual …
drugmonkey.wordpress.com
August 28, 2025 at 7:42 PM
The NIH Simplified Peer Review Framework and Preliminary Data drugmonkey.wordpress.com/2025/08/28/t...
Reposted by Lingfei Wang
NIH to cease posting funding opportunity notices to the Guide drugmonkey.wordpress.com/2025/08/14/n...
NIH to cease posting funding opportunity notices to the Guide
NOT-OD-25-143 notifies the grant seeking community that it will now be harder and less efficient to stay on top of Notices of Funding Opportunity (NOFOs). Starting in Fiscal Year 2026 all such fund…
drugmonkey.wordpress.com
August 14, 2025 at 8:19 PM
NIH to cease posting funding opportunity notices to the Guide drugmonkey.wordpress.com/2025/08/14/n...
Reposted by Lingfei Wang
We're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...
Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development
The spatial organization of chromosomes in the nucleus is fundamental to cellular processes. Contact frequency maps from Hi-C and related chromosome conformation capture assays are increasingly availa...
www.biorxiv.org
August 11, 2025 at 8:41 PM
We're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...
Reposted by Lingfei Wang
Vibe code is legacy code (quoting Steve Krouse) doi.org/10.59350/d3b...
Vibe code is legacy code
Quoting Steve Krouse
doi.org
August 5, 2025 at 9:58 AM
Vibe code is legacy code (quoting Steve Krouse) doi.org/10.59350/d3b...
Reposted by Lingfei Wang
Some musing on Mendelian Randomisation as a technique, triggered by discussions with a variety of colleagues. TL;DR Mendelian Randomisation works well when it used for hypothesis testing of valid exposure => outcome scenarios, as long as the MR assumptions hold (obvs!) and it is performed with care.
July 26, 2025 at 6:30 AM
Some musing on Mendelian Randomisation as a technique, triggered by discussions with a variety of colleagues. TL;DR Mendelian Randomisation works well when it used for hypothesis testing of valid exposure => outcome scenarios, as long as the MR assumptions hold (obvs!) and it is performed with care.
Reposted by Lingfei Wang
Recently, my book THEY CALLED US ENEMY was banned – again – in Tennessee. Book bans are out of control. Huge parts of American history are being restricted. To join me in standing up for the freedom to read, go to pen.org/action. @penamerica.bsky.social @topshelfcomix.bsky.social @idwpublishing.com
July 11, 2025 at 9:05 PM
Recently, my book THEY CALLED US ENEMY was banned – again – in Tennessee. Book bans are out of control. Huge parts of American history are being restricted. To join me in standing up for the freedom to read, go to pen.org/action. @penamerica.bsky.social @topshelfcomix.bsky.social @idwpublishing.com
Reposted by Lingfei Wang
I'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable".
Learn more at: oxbow.readthedocs.io
Learn more at: oxbow.readthedocs.io
July 7, 2025 at 9:22 PM
I'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable".
Learn more at: oxbow.readthedocs.io
Learn more at: oxbow.readthedocs.io
Reposted by Lingfei Wang
For ESIs dealing with grants being rescinded: if an investigator’s 1st substantial independent research award is terminated within the first 3 years of the project period (not due to scientific misconduct ) they can request the reinstatement of ESI status
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
July 2, 2025 at 7:27 PM
For ESIs dealing with grants being rescinded: if an investigator’s 1st substantial independent research award is terminated within the first 3 years of the project period (not due to scientific misconduct ) they can request the reinstatement of ESI status
grants.nih.gov/news-events/...
grants.nih.gov/news-events/...
Too bad that theory lunch in Harvard medical school has ended. Such a good seminar series. Good things never last. Sadly Harvard and possibly the whole academia have took a hit. Hopefully everything and everyone will stay well.
June 30, 2025 at 5:53 PM
Too bad that theory lunch in Harvard medical school has ended. Such a good seminar series. Good things never last. Sadly Harvard and possibly the whole academia have took a hit. Hopefully everything and everyone will stay well.
Reposted by Lingfei Wang
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The forgotten half of scientific thinking | PNAS
The forgotten half of scientific thinking
www.pnas.org
June 26, 2025 at 1:23 PM
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Lingfei Wang
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
June 19, 2025 at 8:55 PM
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
I haven’t heard of this in China.
law enforcement officials say they made a proactive check at Rep. Hortman's home after a lawmaker who lived nearby was shot and found a "police vehicle in the driveway with emergency lights and what appeared to be a police officer at the door coming out of the house." He was actually the gunman.
June 14, 2025 at 3:46 PM
I haven’t heard of this in China.
Reposted by Lingfei Wang
(Longish thread. Apologies)
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
June 8, 2025 at 6:53 PM
(Longish thread. Apologies)
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/
Reposted by Lingfei Wang
from a UNC Trustee: “It is not good governance to give your child a cookie every time they lay on the floor and scream that they want one.”
so telling that he doesn’t see faculty as professionals entitled to the promotion structures outlined in our job contracts. we’re kids demanding treats.
so telling that he doesn’t see faculty as professionals entitled to the promotion structures outlined in our job contracts. we’re kids demanding treats.
After Delay, Chapel Hill Board Votes to Award Tenure
After faculty raised alarm over the board’s delay on the decisions, trustees finally debated and voted by email. A couple of them said they generally opposed tenure.
www.insidehighered.com
June 4, 2025 at 7:50 PM
from a UNC Trustee: “It is not good governance to give your child a cookie every time they lay on the floor and scream that they want one.”
so telling that he doesn’t see faculty as professionals entitled to the promotion structures outlined in our job contracts. we’re kids demanding treats.
so telling that he doesn’t see faculty as professionals entitled to the promotion structures outlined in our job contracts. we’re kids demanding treats.
Reposted by Lingfei Wang
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Another scoop from Jeff Mervis (@policyhound.bsky.social): NSF's ~1400 grant terminations have disproportionately affected PIs from groups underrepresented in science: women, racial & ethnic minorities, & those with disabilities. 1/3
www.science.org/content/arti...
www.science.org/content/arti...
Trump officials take steps toward a radically different NSF
Efforts to shrink staff, budget, and focus have alarmed members of Congress
www.science.org
May 13, 2025 at 10:09 PM
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Reposted by Lingfei Wang
Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 6, 2025 at 5:01 PM
Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lingfei Wang
Go @ascbiology.bsky.social and partner societies! If your scientific society is not pushing back on illegal actions of the President. remind them that we need leadership and hiding and capitulation are NOT helping their members
Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration.
www.ascb.org/society-news...
www.ascb.org/society-news...
Leading Life Science Organizations: Unlawful Grant Terminations Pose Grave Threat to America’s Innovation Pipeline - ASCB
Amicus Brief Filed in Support of Suit Calling for Immediate Funding Restoration WASHINGTON, DC – Four leading life science organizations, including the ASCB, filed an amicus brief today asking the cou...
www.ascb.org
May 2, 2025 at 11:14 PM
Go @ascbiology.bsky.social and partner societies! If your scientific society is not pushing back on illegal actions of the President. remind them that we need leadership and hiding and capitulation are NOT helping their members