Lina Carlini
linacarlini.bsky.social
Lina Carlini
@linacarlini.bsky.social
Assistant Professor, Laufer Center for Physical & Quantitative Biology, Stony Brook University
Reposted by Lina Carlini
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
www.science.org
October 10, 2025 at 1:14 PM
Reposted by Lina Carlini
Ken A. Dill to Receive Biophysical Society’s 2026 Founders Award buff.ly/OZ3VUIk
September 24, 2025 at 8:15 PM
Stony Brook’s Laufer Center for Physical & Quantitative Biology invites applications for an endowed faculty position (assistant/ associate professor). Join a top interdisciplinary hub in quantitative biology! Apply by Dec 1: apply.interfolio.com/173357
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September 17, 2025 at 5:45 PM
Reposted by Lina Carlini
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
September 15, 2025 at 8:09 PM
Reposted by Lina Carlini
📢Last few days to apply for this round of our #microscopy training grants with @jcellsci.bsky.social

Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.

Apply by 5 September

www.biologists.com/grants/jcs-f...
August 29, 2025 at 1:14 PM
Reposted by Lina Carlini
New preprint online!

So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!

Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
August 28, 2025 at 7:26 AM
Reposted by Lina Carlini
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
Reposted by Lina Carlini
Hey #biology #postdocs out there, are you worried about the academic job market in the current climate? Do not! We are hiring, and we are an absolutely AWESOME department! 🧪

Apply now: www.stonybrook.edu/commcms/bioc...
Opportunities | Biochemistry & Cell Biology
Department of Biochemistry and Cell Biology at Stony Brook University
www.stonybrook.edu
August 15, 2025 at 7:32 PM
Reposted by Lina Carlini
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
Reposted by Lina Carlini
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
May 23, 2025 at 7:57 PM
Reposted by Lina Carlini
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
May 21, 2025 at 4:10 PM
Reposted by Lina Carlini
We've developed a single-molecule imaging approach to study how #influenza A viruses interact with live cells at the nanoscale. We found that cellular receptors show a specific organization and turnover at the virus-cell interface. 👉 www.nature.com/articles/s41...
@combinemarvproject.bsky.social
May 8, 2025 at 7:19 AM
Reposted by Lina Carlini
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
April 24, 2025 at 1:19 PM
Reposted by Lina Carlini
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
April 23, 2025 at 2:04 PM
Reposted by Lina Carlini
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.

www.biorxiv.org/content/10.1...
April 22, 2025 at 1:02 AM