Lackner Lab
@lacknerlab.bsky.social
Chair of Biochemistry of Microorgansims at @unibayreuth.bsky.social. Topics: Microbes, bioactive natural products and synthetic biology
Reposted by Lackner Lab
🔓Take a look at a #OpenAccess review by Gerald Lackner & co. covering recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin #secmet #natprod
📍 @lacknerlab.bsky.social @unibayreuth.bsky.social @uni-jena.de
📍 @lacknerlab.bsky.social @unibayreuth.bsky.social @uni-jena.de
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin
Covering: 2011 to 2025 The importance of redox cofactors like nicotinamide adenine dinucleotide or flavin adenine dinucleotide as cofactors for enzymatic reactions in living organisms is widely…
pubs.rsc.org
September 9, 2025 at 11:06 AM
🔓Take a look at a #OpenAccess review by Gerald Lackner & co. covering recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin #secmet #natprod
📍 @lacknerlab.bsky.social @unibayreuth.bsky.social @uni-jena.de
📍 @lacknerlab.bsky.social @unibayreuth.bsky.social @uni-jena.de
Reposted by Lackner Lab
Great #ISMEJournal review by Ingrid Richter, Hannah Büttner, Christian Hertweck @leibniz-hki.de @microverse.bsky.social
Endofungal Bacteria as Hidden Facilitators of Biotic Interactions
academic.oup.com/ismej/advanc...
Endofungal Bacteria as Hidden Facilitators of Biotic Interactions
academic.oup.com/ismej/advanc...
Endofungal Bacteria as Hidden Facilitators of Biotic Interactions
Abstract. Fungi play pivotal roles in ecology and human health, driving nutrient cycling, supporting antibiotic production, and posing threats through toxi
academic.oup.com
June 25, 2025 at 7:16 AM
Great #ISMEJournal review by Ingrid Richter, Hannah Büttner, Christian Hertweck @leibniz-hki.de @microverse.bsky.social
Endofungal Bacteria as Hidden Facilitators of Biotic Interactions
academic.oup.com/ismej/advanc...
Endofungal Bacteria as Hidden Facilitators of Biotic Interactions
academic.oup.com/ismej/advanc...
How can we make genetically engineered microbes safer for medical or environmental use? 🧬 💊
Our PhD student Carla Maneira tackled this challenge and developed efficient safety strategies for both lab and probiotic yeast. 💡🧪Check out the solutions in our latest publication! 📄 doi.org/10.1016/j.ym...
Our PhD student Carla Maneira tackled this challenge and developed efficient safety strategies for both lab and probiotic yeast. 💡🧪Check out the solutions in our latest publication! 📄 doi.org/10.1016/j.ym...
Redirecting
doi.org
July 3, 2025 at 6:02 AM
How can we make genetically engineered microbes safer for medical or environmental use? 🧬 💊
Our PhD student Carla Maneira tackled this challenge and developed efficient safety strategies for both lab and probiotic yeast. 💡🧪Check out the solutions in our latest publication! 📄 doi.org/10.1016/j.ym...
Our PhD student Carla Maneira tackled this challenge and developed efficient safety strategies for both lab and probiotic yeast. 💡🧪Check out the solutions in our latest publication! 📄 doi.org/10.1016/j.ym...
Reposted by Lackner Lab
At the top of each article in eLife is an eLife Assessment.
They summarise the reviews using consistent assessment terms in bold to help you quickly understand the strengths and weaknesses of the research.
🔗 buff.ly/6HxRbhC
They summarise the reviews using consistent assessment terms in bold to help you quickly understand the strengths and weaknesses of the research.
🔗 buff.ly/6HxRbhC
May 20, 2025 at 8:02 PM
At the top of each article in eLife is an eLife Assessment.
They summarise the reviews using consistent assessment terms in bold to help you quickly understand the strengths and weaknesses of the research.
🔗 buff.ly/6HxRbhC
They summarise the reviews using consistent assessment terms in bold to help you quickly understand the strengths and weaknesses of the research.
🔗 buff.ly/6HxRbhC
What the f* is mycofactocin?
If you’ve ever wondered about the unusual cofactor – wonder no more. We’ve written up a review article for NPR covering its discovery, biosynthesis, and biological roles. Huge thanks to all co-authors who made this happen!
pubs.rsc.org/en/content/a...
If you’ve ever wondered about the unusual cofactor – wonder no more. We’ve written up a review article for NPR covering its discovery, biosynthesis, and biological roles. Huge thanks to all co-authors who made this happen!
pubs.rsc.org/en/content/a...
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin
Covering: 2011 to 2025The importance of redox cofactors like nicotinamide adenine dinucleotide or flavin adenine dinucleotide as cofactors for enzymatic reactions in living organisms is widely known. ...
pubs.rsc.org
May 19, 2025 at 8:12 AM
What the f* is mycofactocin?
If you’ve ever wondered about the unusual cofactor – wonder no more. We’ve written up a review article for NPR covering its discovery, biosynthesis, and biological roles. Huge thanks to all co-authors who made this happen!
pubs.rsc.org/en/content/a...
If you’ve ever wondered about the unusual cofactor – wonder no more. We’ve written up a review article for NPR covering its discovery, biosynthesis, and biological roles. Huge thanks to all co-authors who made this happen!
pubs.rsc.org/en/content/a...
Reposted by Lackner Lab
UPDATE: Mehr als 7200 aus der deutschen Wissenschaftscommunity haben in acht Tagen der Klima-Appell der Bayreuther Scientists for Future unterschrieben.
Wir öffnen die Mitzeichnungsmöglichkeit für den Appell nun erneut bis zur konstituierenden Sitzung des neuen Deutschen Bundestags am 25.03.2025.
Wir öffnen die Mitzeichnungsmöglichkeit für den Appell nun erneut bis zur konstituierenden Sitzung des neuen Deutschen Bundestags am 25.03.2025.
March 13, 2025 at 10:37 AM
UPDATE: Mehr als 7200 aus der deutschen Wissenschaftscommunity haben in acht Tagen der Klima-Appell der Bayreuther Scientists for Future unterschrieben.
Wir öffnen die Mitzeichnungsmöglichkeit für den Appell nun erneut bis zur konstituierenden Sitzung des neuen Deutschen Bundestags am 25.03.2025.
Wir öffnen die Mitzeichnungsmöglichkeit für den Appell nun erneut bis zur konstituierenden Sitzung des neuen Deutschen Bundestags am 25.03.2025.
Great to see our article about the role of MftG in mycobacterial respiration highlighted in eLife: doi.org/10.7554/eLif...
Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain
In the bacterium M. smegmatis, an enzyme called MftG allows the the cofactor mycofactocin to transfers electrons released during ethanol metabolism to the electron transport chain.
doi.org
March 6, 2025 at 6:56 AM
Great to see our article about the role of MftG in mycobacterial respiration highlighted in eLife: doi.org/10.7554/eLif...
Reposted by Lackner Lab
Die Mobile Opferberatung in Magdeburg berichtet, dass nach dem Anschlag von Magdeburg die Zahl rechtsextremer Gewalttaten deutlich zugenommen hat. Mehr als die Hälfte war rassistisch motiviert. Rechte Gewalt eskaliert und es kriegt nicht mal irgendjemand mit, wenn die "Ausländer" die Opfer sind.
March 5, 2025 at 12:59 PM
Die Mobile Opferberatung in Magdeburg berichtet, dass nach dem Anschlag von Magdeburg die Zahl rechtsextremer Gewalttaten deutlich zugenommen hat. Mehr als die Hälfte war rassistisch motiviert. Rechte Gewalt eskaliert und es kriegt nicht mal irgendjemand mit, wenn die "Ausländer" die Opfer sind.
Reposted by Lackner Lab
🧐 Research in focus, part 2: Infection Biology
At #LeibnizHKI, we are studying microbial infections, especially fungal pathogens, to understand host-pathogen interactions and develop new treatment strategies.
Stay tuned for all updates on our #InfectionBiology research! 🔔
At #LeibnizHKI, we are studying microbial infections, especially fungal pathogens, to understand host-pathogen interactions and develop new treatment strategies.
Stay tuned for all updates on our #InfectionBiology research! 🔔
February 13, 2025 at 2:14 PM
🧐 Research in focus, part 2: Infection Biology
At #LeibnizHKI, we are studying microbial infections, especially fungal pathogens, to understand host-pathogen interactions and develop new treatment strategies.
Stay tuned for all updates on our #InfectionBiology research! 🔔
At #LeibnizHKI, we are studying microbial infections, especially fungal pathogens, to understand host-pathogen interactions and develop new treatment strategies.
Stay tuned for all updates on our #InfectionBiology research! 🔔
Reposted by Lackner Lab
🧐 Research in focus, part 1: Natural Products
At #LeibnizHKI, we are investigating microbial natural products to discover new bioactive compounds, in particular antiinfectives.
Stay tuned for all updates on our #NaturalProducts research! 🔔
At #LeibnizHKI, we are investigating microbial natural products to discover new bioactive compounds, in particular antiinfectives.
Stay tuned for all updates on our #NaturalProducts research! 🔔
February 13, 2025 at 2:11 PM
🧐 Research in focus, part 1: Natural Products
At #LeibnizHKI, we are investigating microbial natural products to discover new bioactive compounds, in particular antiinfectives.
Stay tuned for all updates on our #NaturalProducts research! 🔔
At #LeibnizHKI, we are investigating microbial natural products to discover new bioactive compounds, in particular antiinfectives.
Stay tuned for all updates on our #NaturalProducts research! 🔔
Reposted by Lackner Lab
Hello #Bluesky community! 👋 Welcome to the Leibniz-HKI!
We’re researching microbial #NaturalProducts and #FungalPathogens to develop new diagnostics and treatments for #InfectiousDiseases, particularly against rising antimicrobial resistance.
💡 Follow us for the latest updates on our research!
We’re researching microbial #NaturalProducts and #FungalPathogens to develop new diagnostics and treatments for #InfectiousDiseases, particularly against rising antimicrobial resistance.
💡 Follow us for the latest updates on our research!
February 13, 2025 at 2:06 PM
Hello #Bluesky community! 👋 Welcome to the Leibniz-HKI!
We’re researching microbial #NaturalProducts and #FungalPathogens to develop new diagnostics and treatments for #InfectiousDiseases, particularly against rising antimicrobial resistance.
💡 Follow us for the latest updates on our research!
We’re researching microbial #NaturalProducts and #FungalPathogens to develop new diagnostics and treatments for #InfectiousDiseases, particularly against rising antimicrobial resistance.
💡 Follow us for the latest updates on our research!
Reposted by Lackner Lab
Excited to share our latest preprint! A fascinating story of chemical dialogue and microbial warfare: the Bacillus extracellular matrix acts as a key driver in the antagonistic interaction with Botrytis, while the fungus mounts a multi-layered defense.
🔗
www.biorxiv.org/content/10.1...
🔗
www.biorxiv.org/content/10.1...
The offensive role of the Bacillus extracellular matrix in driving metabolite-mediated dialogue and adaptive strategies with pathogenic fungi
Bacterial□fungal interactions have traditionally been attributed to secondary metabolites, but the role of the bacterial extracellular matrix (ECM) in shaping these relationships has remained unclear....
www.biorxiv.org
February 11, 2025 at 8:01 AM
Excited to share our latest preprint! A fascinating story of chemical dialogue and microbial warfare: the Bacillus extracellular matrix acts as a key driver in the antagonistic interaction with Botrytis, while the fungus mounts a multi-layered defense.
🔗
www.biorxiv.org/content/10.1...
🔗
www.biorxiv.org/content/10.1...
Reposted by Lackner Lab
In Nature Chemical Biology today, we reveal how microbes clean our atmospheres by consuming carbon monoxide (CO) gas. A methodological tour de force from Ashleigh Kropp, Rhys Grinter, and David Gillett with broad implications for the atmosphere and bioenergetics. www.nature.com/articles/s41...
Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria - Nature Chemical Biology
Here, Kropp et al. use cryo-electron microscopy and structural modeling to show that the enzyme [MoCu]-CO dehydrogenase interacts with its partner, the membrane-bound quinone-binding protein CoxG, to ...
www.nature.com
January 29, 2025 at 10:21 AM
In Nature Chemical Biology today, we reveal how microbes clean our atmospheres by consuming carbon monoxide (CO) gas. A methodological tour de force from Ashleigh Kropp, Rhys Grinter, and David Gillett with broad implications for the atmosphere and bioenergetics. www.nature.com/articles/s41...
Curious how tuberculosis-related mycobacteria process alcohol? We have identified a novel enzyme that couples ethanol metabolism to respiration in these organisms. Many thanks to all authors, especially @patriciagraca.bsky.social, and our collaborators from the Papenfort and Vilotijevic labs!
MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration
The mftG gene, present in the majority of mycofactocin gene clusters, encodes an oxidoreductase that facilitates ethanol utilization by reoxidation of mycofactocins and channeling electrons towards th...
doi.org
January 30, 2025 at 8:44 AM
Curious how tuberculosis-related mycobacteria process alcohol? We have identified a novel enzyme that couples ethanol metabolism to respiration in these organisms. Many thanks to all authors, especially @patriciagraca.bsky.social, and our collaborators from the Papenfort and Vilotijevic labs!
Reposted by Lackner Lab
Great paper by the group of @larsjeuken.bsky.social in J. Biol. Chem. with first author Tijn van der Velden. Cytochrome bd of M. tuberculosis is RedOx-regulated through a disulfide with potential important implications for survival in the phagosome #chemsky #ChemBio (1/2)
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond
Cytochrome bd from Mycobacterium tuberculosis (Mtbd) is a menaquinol oxidase that
has gained interest as an antibiotic target because of its importance in survival
under infectious conditions. Mtbd co...
www.jbc.org
January 17, 2025 at 7:34 AM
Great paper by the group of @larsjeuken.bsky.social in J. Biol. Chem. with first author Tijn van der Velden. Cytochrome bd of M. tuberculosis is RedOx-regulated through a disulfide with potential important implications for survival in the phagosome #chemsky #ChemBio (1/2)
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Discover the remarkable potential of engineering #yeast in medical applications in our latest review article. Thanks to Carla Maneira and Alexandre Chamas for the great work!
Engineering Saccharomyces cerevisiae for medical applications - Microbial Cell Factories
Background During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable....
link.springer.com
January 9, 2025 at 7:38 PM
Discover the remarkable potential of engineering #yeast in medical applications in our latest review article. Thanks to Carla Maneira and Alexandre Chamas for the great work!
Reposted by Lackner Lab
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
academic.oup.com
December 10, 2024 at 8:05 AM
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
Reposted by Lackner Lab
Das bayerische Ziel der #Klimaneutralität 2040 ist richtig und wichtig. Die bayerischen Universitäten und Hochschulen für angewandte Wissenschaften (HAWs) müssen und wollen hier vorangehen.
Heute ging unser Offener Brief mit über 1500 Unterschriften in die Post.
Heute ging unser Offener Brief mit über 1500 Unterschriften in die Post.
December 11, 2024 at 11:30 AM
Das bayerische Ziel der #Klimaneutralität 2040 ist richtig und wichtig. Die bayerischen Universitäten und Hochschulen für angewandte Wissenschaften (HAWs) müssen und wollen hier vorangehen.
Heute ging unser Offener Brief mit über 1500 Unterschriften in die Post.
Heute ging unser Offener Brief mit über 1500 Unterschriften in die Post.
Reposted by Lackner Lab
Unser Offener Brief "Klimaneutraler Hochschulbetrieb 2040" an die #bayerische Staatsregierung hat bereits über 800 Unterschriften. Darunter über 200 Professor:innen bayerischer Universitäten und HAWs.
www.bayceer.uni-bayreuth.de/s4f/de/top/5...
www.bayceer.uni-bayreuth.de/s4f/de/top/5...
December 6, 2024 at 12:02 PM
Unser Offener Brief "Klimaneutraler Hochschulbetrieb 2040" an die #bayerische Staatsregierung hat bereits über 800 Unterschriften. Darunter über 200 Professor:innen bayerischer Universitäten und HAWs.
www.bayceer.uni-bayreuth.de/s4f/de/top/5...
www.bayceer.uni-bayreuth.de/s4f/de/top/5...
Das #Darmmikrobiom als Garant für Gesundheit und Wohlbefinden? Hier ist mein Interview mit dem Ernährungsradar, ein Gemeinschaftsprojekt des Kompetenzzentrum für Ernährung (KErn), der Universität Bayreuth und der Akademie für Neue Medien (Bildungswerk) e.V. www.ernaehrungsradar.de/kuestions-da...
KUestions: Darmmikrobiom
Das Interview mit Prof. Gerald Lackner von der Universität Bayreuth beleuchtet die Bedeutung des Darmmikrobioms für unsere Gesundheit.
www.ernaehrungsradar.de
December 4, 2024 at 2:52 PM
Das #Darmmikrobiom als Garant für Gesundheit und Wohlbefinden? Hier ist mein Interview mit dem Ernährungsradar, ein Gemeinschaftsprojekt des Kompetenzzentrum für Ernährung (KErn), der Universität Bayreuth und der Akademie für Neue Medien (Bildungswerk) e.V. www.ernaehrungsradar.de/kuestions-da...
Reposted by Lackner Lab
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪