Lukas A. Basedow, PhD
@labasedow.bsky.social
Postdoc & Clinical Psychologist @unimarburg.bsky.social & @SFB-TRR-289.bsky.social
Coordinator of the DG Sucht - ECR network.
Interested in placebo effects, drugs & clinical psychology. All views my own.
Coordinator of the DG Sucht - ECR network.
Interested in placebo effects, drugs & clinical psychology. All views my own.
Reposted by Lukas A. Basedow, PhD
I've never experienced anything like this in my life, where people keep telling me that "we have to use AI or else we'll be left behind" but they don't actually tell me exactly what problem they are hoping to solve with the "AI" or how we would know it was useful. But we must use it! Apparently.
March 19, 2025 at 4:11 PM
I've never experienced anything like this in my life, where people keep telling me that "we have to use AI or else we'll be left behind" but they don't actually tell me exactly what problem they are hoping to solve with the "AI" or how we would know it was useful. But we must use it! Apparently.
Finally got around to reading this great paper. A really insightful argument for treating psychedelic-assisted therapy as psychotherapy!
New long-read theory paper in Psychological Review:
Im short, we propose that effective psychedelic therapy employs the uniquely context-dependent effects of psychedelic drugs to engage & augment the same psychological change processes that underlie all effective psychotherapies.
Full text below ⬇️
Im short, we propose that effective psychedelic therapy employs the uniquely context-dependent effects of psychedelic drugs to engage & augment the same psychological change processes that underlie all effective psychotherapies.
Full text below ⬇️
October 24, 2025 at 1:43 PM
Finally got around to reading this great paper. A really insightful argument for treating psychedelic-assisted therapy as psychotherapy!
With Zalsupindole (see quoted skeet) and Bretisilocin (5F-MET; journals.sagepub.com/doi/10.1177/...) there are very exciting things happening in the psychedelic drug development world. 5F-MET especially might be well suited to psychedelic-assisted psychotherapy with a half life of 40-50 minutes!
October 24, 2025 at 12:59 PM
With Zalsupindole (see quoted skeet) and Bretisilocin (5F-MET; journals.sagepub.com/doi/10.1177/...) there are very exciting things happening in the psychedelic drug development world. 5F-MET especially might be well suited to psychedelic-assisted psychotherapy with a half life of 40-50 minutes!
Reposted by Lukas A. Basedow, PhD
Are you a journal editor in Psychology? There's a lot you can do to help support PCI Psych! PCI Psychology is a journal-independent peer review platform where journal editors like you evaluate and recommend preprints, that can then be published in PCI-friendly partner journals. 1/🧵 #PsychSciSky
October 22, 2025 at 9:46 PM
Are you a journal editor in Psychology? There's a lot you can do to help support PCI Psych! PCI Psychology is a journal-independent peer review platform where journal editors like you evaluate and recommend preprints, that can then be published in PCI-friendly partner journals. 1/🧵 #PsychSciSky
Reposted by Lukas A. Basedow, PhD
Seeing lots of reactions to this compelling paper - showing VTA dopamine is linked to cue and outcome induced behavioral reactions: www.nature.com/articles/s41...
I have some thoughts…
I have some thoughts…
Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning - Nature Communications
VTA dopamine activity control movement-related performance, not reward prediction errors. Here, authors show that behavioral changes during Pavlovian learning explain DA activity regardless of reward ...
www.nature.com
October 15, 2025 at 8:57 PM
Seeing lots of reactions to this compelling paper - showing VTA dopamine is linked to cue and outcome induced behavioral reactions: www.nature.com/articles/s41...
I have some thoughts…
I have some thoughts…
Reposted by Lukas A. Basedow, PhD
Results of the replication are in!
Chocolate is more desirable than poop:
Cohen's d_rm = 6.20, 95%CI [5.63, 6.78]
N = 486, two single item 1-7 Likert scales of desirability.
w/
@jamiecummins.bsky.social
Chocolate is more desirable than poop:
Cohen's d_rm = 6.20, 95%CI [5.63, 6.78]
N = 486, two single item 1-7 Likert scales of desirability.
w/
@jamiecummins.bsky.social
Make an effect size prediction!
@jamiecummins.bsky.social and I are replicating Balcetis & Dunning's (2010) "chocolate is more desirable than poop" (Cohen's d = 4.52)
Let us known in the replies what effect size you think we'll find. Details of the study in the thread below.
@jamiecummins.bsky.social and I are replicating Balcetis & Dunning's (2010) "chocolate is more desirable than poop" (Cohen's d = 4.52)
Let us known in the replies what effect size you think we'll find. Details of the study in the thread below.
October 14, 2025 at 6:16 PM
Results of the replication are in!
Chocolate is more desirable than poop:
Cohen's d_rm = 6.20, 95%CI [5.63, 6.78]
N = 486, two single item 1-7 Likert scales of desirability.
w/
@jamiecummins.bsky.social
Chocolate is more desirable than poop:
Cohen's d_rm = 6.20, 95%CI [5.63, 6.78]
N = 486, two single item 1-7 Likert scales of desirability.
w/
@jamiecummins.bsky.social
Reposted by Lukas A. Basedow, PhD
Excellent opportunity to pursue a PhD on dissociative states with @susannahpick.bsky.social and me at the IoPPN @kingsioppn.bsky.social Reach out to us with any questions
Applications opening on 8th October for our @kingsioppn.bsky.social MRC DTP PhD studentships for 2026 entry - lots of great projects being offered including one from me and @devinterhune.bsky.social on transdiagnostic dissociative states/symptoms kcl-mrcdtp.com/apply/projec...
Projects - MRC DTP
kcl-mrcdtp.com
September 28, 2025 at 9:52 PM
Excellent opportunity to pursue a PhD on dissociative states with @susannahpick.bsky.social and me at the IoPPN @kingsioppn.bsky.social Reach out to us with any questions
Reposted by Lukas A. Basedow, PhD
Total wichtige Studie.
Die Industrie ist hier nicht nur unglaubwürdig, sondern geradezu zynisch. In Schottland wurde der Mindestpreis, der sich dezidiert gegen den Konsum großer Mengen billigen Alkohols richtet, jahrelang von der Alkoholindustrie gerichtlich aufgehalten.
Die Industrie ist hier nicht nur unglaubwürdig, sondern geradezu zynisch. In Schottland wurde der Mindestpreis, der sich dezidiert gegen den Konsum großer Mengen billigen Alkohols richtet, jahrelang von der Alkoholindustrie gerichtlich aufgehalten.
Alkoholproduzenten setzen auf verantwortungsvollen Konsum und Risikokompetenz. Unsere Berechnungen zeigen: Mindestens die Hälfte ihres Umsatzes lässt sich auf eindeutig gesundheitsschädigenden Alkoholkonsum zurückführen. Wie glaubwürdig sind also solche Bekenntnisse?
👉 doi.org/10.1024/0939...
👉 doi.org/10.1024/0939...
Das Geschäft mit dem Leid – wie viel Umsatz macht die Alkoholindustrie mit Risiko- und Hochkonsum? | SUCHT
Zusammenfassung: Zielsetzung: Während die Alkoholindustrie öffentlich für einen „verantwortungsvollen“ Alkoholkonsum wirbt, deuten Studienergebnisse aus anderen Ländern darauf hin, dass mehr als die H...
doi.org
September 29, 2025 at 8:17 AM
Total wichtige Studie.
Die Industrie ist hier nicht nur unglaubwürdig, sondern geradezu zynisch. In Schottland wurde der Mindestpreis, der sich dezidiert gegen den Konsum großer Mengen billigen Alkohols richtet, jahrelang von der Alkoholindustrie gerichtlich aufgehalten.
Die Industrie ist hier nicht nur unglaubwürdig, sondern geradezu zynisch. In Schottland wurde der Mindestpreis, der sich dezidiert gegen den Konsum großer Mengen billigen Alkohols richtet, jahrelang von der Alkoholindustrie gerichtlich aufgehalten.
Reposted by Lukas A. Basedow, PhD
We often hear from reviewers: "what about demand effects?" So we developed a method to eliminate them. Something weird happened during testing: We couldn’t detect demand effects in the first place! (1/8)
September 15, 2025 at 5:19 PM
We often hear from reviewers: "what about demand effects?" So we developed a method to eliminate them. Something weird happened during testing: We couldn’t detect demand effects in the first place! (1/8)
Reposted by Lukas A. Basedow, PhD
It has often been suggested that psychotherapy works because patients expect it will work before they have even started treatment. But what if treatment expectations are an emergent phenomenon that develops in the course of psychotherapy and contributes to a successful outcome?
September 9, 2025 at 10:28 AM
It has often been suggested that psychotherapy works because patients expect it will work before they have even started treatment. But what if treatment expectations are an emergent phenomenon that develops in the course of psychotherapy and contributes to a successful outcome?
Reposted by Lukas A. Basedow, PhD
September 3, 2025 at 9:39 AM
Reposted by Lukas A. Basedow, PhD
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Phd candidate or postdoc– Genetic determinants of opioid responsiveness
The Department of Research and Development at the Division of Emergencies and Critical Care, Oslo University Hospital in collaboration with Leknes Affective Brain lab (www.affectivebrains.com) and the...
2411.webcruiter.no
August 29, 2025 at 2:20 PM
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Fully funded position in Oslo (PhD student or postdoc)
Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
Reposted by Lukas A. Basedow, PhD
Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation
Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...
www.medrxiv.org
August 27, 2025 at 4:17 PM
Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
Reposted by Lukas A. Basedow, PhD
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
August 18, 2025 at 1:17 PM
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Lukas A. Basedow, PhD
1. I need to recover this thread from X about a review on lithium in tap-water and suicide. It shows that papers aren't retracted despite being total nonsense
1. There seem to be several issues with this new paper about lithium in tap water and suicide. Thanks for sending me a pdf >
Lithium in water and suicide rates. A review.
R = −0.576.
That's a massive effect. Too good to be true?
https://journals.lww.com/intclinpsychopharm/Abstract/2023/03000/An_investigation_into_the_association_between.2.aspx
R = −0.576.
That's a massive effect. Too good to be true?
https://journals.lww.com/intclinpsychopharm/Abstract/2023/03000/An_investigation_into_the_association_between.2.aspx
August 17, 2025 at 5:20 PM
1. I need to recover this thread from X about a review on lithium in tap-water and suicide. It shows that papers aren't retracted despite being total nonsense
Reposted by Lukas A. Basedow, PhD
📣 Noch 2 Tage bis zum Bewerbungsschluss!
Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩
Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩
🚀 Unsere Arbeitsgruppe an der TU Dresden sucht Verstärkung!
Wir bieten eine Postdoc- oder WiMi-Stelle (50%, E13 TV-L) ab 15.09.2025 an der Professur für Klinische Kinder- und Jugendpsychologie.
Bewirb dich bis 7.8. und werde Teil unseres Teams!
👇👇👇
tu-dresden.de/mn/psycholog...
Wir bieten eine Postdoc- oder WiMi-Stelle (50%, E13 TV-L) ab 15.09.2025 an der Professur für Klinische Kinder- und Jugendpsychologie.
Bewirb dich bis 7.8. und werde Teil unseres Teams!
👇👇👇
tu-dresden.de/mn/psycholog...
August 5, 2025 at 10:30 AM
📣 Noch 2 Tage bis zum Bewerbungsschluss!
Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩
Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩
Reposted by Lukas A. Basedow, PhD
Bit of a quiet landmark this study. Offers significant evidence to suggest non hallucinogenic psychedelic analogs could be effective as antidepressants. Amazing stuff.
The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation - Nature Neuroscience
Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately increasing extrace...
www.nature.com
August 5, 2025 at 7:56 AM
Bit of a quiet landmark this study. Offers significant evidence to suggest non hallucinogenic psychedelic analogs could be effective as antidepressants. Amazing stuff.
Reposted by Lukas A. Basedow, PhD
Huge congratulations to our two CRC members @labasedow.bsky.social and Marcel Wilhelm from @unimarburg.bsky.social for winning two out of four science slam prizes! 🥳🤯
Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩
Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩
June 18, 2025 at 12:39 PM
Huge congratulations to our two CRC members @labasedow.bsky.social and Marcel Wilhelm from @unimarburg.bsky.social for winning two out of four science slam prizes! 🥳🤯
Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩
Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩
Really happy to be able to present my Poster regarding placebo-induced psychedelic effects at #SIPSplacebo2025
Funded by the @sfb-trr-289.bsky.social
Funded by the @sfb-trr-289.bsky.social
June 17, 2025 at 2:25 PM
Really happy to be able to present my Poster regarding placebo-induced psychedelic effects at #SIPSplacebo2025
Funded by the @sfb-trr-289.bsky.social
Funded by the @sfb-trr-289.bsky.social
Really happy to have participated again. Always a fun challenge!
@sfb-trr-289.bsky.social @sipsplacebo.bsky.social
#SIPSplacebo2025
@sfb-trr-289.bsky.social @sipsplacebo.bsky.social
#SIPSplacebo2025
Next up, @labasedow.bsky.social from @unimarburg.bsky.social tells us about fake drugs and real highs! 🫠
But can we really get high from a placebo drug? What are the mechanisms?
But can we really get high from a placebo drug? What are the mechanisms?
June 17, 2025 at 9:09 AM
Really happy to have participated again. Always a fun challenge!
@sfb-trr-289.bsky.social @sipsplacebo.bsky.social
#SIPSplacebo2025
@sfb-trr-289.bsky.social @sipsplacebo.bsky.social
#SIPSplacebo2025
Reposted by Lukas A. Basedow, PhD
Huge thanks to Lene Vase for highlighting both our recent placebo meta-analysis and the patient advisory board ❤️
The meta-analysis: www.biorxiv.org/content/10.1...
The patient advisory board: treatment-expectation.de/projekte-peo...
@sipsplacebo.bsky.social
#SIPSplacebo2025
The meta-analysis: www.biorxiv.org/content/10.1...
The patient advisory board: treatment-expectation.de/projekte-peo...
@sipsplacebo.bsky.social
#SIPSplacebo2025
June 17, 2025 at 8:33 AM
Huge thanks to Lene Vase for highlighting both our recent placebo meta-analysis and the patient advisory board ❤️
The meta-analysis: www.biorxiv.org/content/10.1...
The patient advisory board: treatment-expectation.de/projekte-peo...
@sipsplacebo.bsky.social
#SIPSplacebo2025
The meta-analysis: www.biorxiv.org/content/10.1...
The patient advisory board: treatment-expectation.de/projekte-peo...
@sipsplacebo.bsky.social
#SIPSplacebo2025
Reposted by Lukas A. Basedow, PhD
Glad to see this paper out finally. Well done @trpwolff.bsky.social for driving it!
I think this idea has potential for significant impact in psychedelic drug development.
/1 🧵 👇
📄 doi.org/10.1177/2050...
I think this idea has potential for significant impact in psychedelic drug development.
/1 🧵 👇
📄 doi.org/10.1177/2050...
June 16, 2025 at 10:04 PM
Glad to see this paper out finally. Well done @trpwolff.bsky.social for driving it!
I think this idea has potential for significant impact in psychedelic drug development.
/1 🧵 👇
📄 doi.org/10.1177/2050...
I think this idea has potential for significant impact in psychedelic drug development.
/1 🧵 👇
📄 doi.org/10.1177/2050...
Reposted by Lukas A. Basedow, PhD
✨ Job opportunity! ✨ We're currently seeking a Research Associate in Psychology for a new project led by @fieldmatt.bsky.social which will use machine learning to develop a better understanding of why many people drop out of treatment for gambling problems. More project info at: bit.ly/45WEyVb
Research Associate in Psychology at University of Sheffield
An opportunity for an academic position as a Research Associate in Psychology is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
www.jobs.ac.uk
June 16, 2025 at 9:04 AM
✨ Job opportunity! ✨ We're currently seeking a Research Associate in Psychology for a new project led by @fieldmatt.bsky.social which will use machine learning to develop a better understanding of why many people drop out of treatment for gambling problems. More project info at: bit.ly/45WEyVb
Reposted by Lukas A. Basedow, PhD
PCI Psychology is here!! 🎉🥳
After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org
#PsychSciSky #scipub
After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org
#PsychSciSky #scipub
June 11, 2025 at 11:03 PM
PCI Psychology is here!! 🎉🥳
After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org
#PsychSciSky #scipub
After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org
#PsychSciSky #scipub
Reposted by Lukas A. Basedow, PhD
An der @rptu.bsky.social wird eine neue W2-Professur "Klinische Psychologie und Psychopathologie" geschaffen 🎉
Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung!
jobs.rptu.de/jobposting/0...
Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung!
jobs.rptu.de/jobposting/0...
W 2-Professur für Klinische Psychologie und Psychopathologie (m/w/d)
jobs.rptu.de
April 7, 2025 at 7:51 AM
An der @rptu.bsky.social wird eine neue W2-Professur "Klinische Psychologie und Psychopathologie" geschaffen 🎉
Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung!
jobs.rptu.de/jobposting/0...
Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung!
jobs.rptu.de/jobposting/0...