Krish Sanghvi
@krishsanghvi11.bsky.social
Post doc- sexual selection, life history
Pinned
Krish Sanghvi
@krishsanghvi11.bsky.social
· Jun 27
Diagnosing confounded Bateman gradients
Abstract. The Bateman gradient is a fundamental metric of sexual selection, often interpreted as the fitness advantage individuals gain by increasing their
academic.oup.com
How to interpret sexual selection using Bateman gradients? When are these not informative & how should researchers identify, deal with confounded gradients? We simulate anisogamy & sperm competition to provide a guide for using Bateman gradients. Out in Evolution
academic.oup.com/evolut/advan...
academic.oup.com/evolut/advan...
Reposted by Krish Sanghvi
Fungi coat the eggs of stinkbugs, creating a shield that protects the embryos from parasitic wasps, researchers report.
Learn more: https://scim.ag/43kl3np
Learn more: https://scim.ag/43kl3np
November 10, 2025 at 11:26 PM
Fungi coat the eggs of stinkbugs, creating a shield that protects the embryos from parasitic wasps, researchers report.
Learn more: https://scim.ag/43kl3np
Learn more: https://scim.ag/43kl3np
Reposted by Krish Sanghvi
Certain micro-RNA molecules in sperm are linked to embryo development and may help predict IVF success, offering potential for improved fertility diagnostics and treatment strategies. doi.org/g9wcvj
Sperm molecules can predict IVF success
The sperm is not a passive supplier of genetic material to the egg. A study from Linköping University, Sweden, shows that certain molecules that come with the sperm, so-called micro-RNA, contribute to the development of the embryo several days after conception.
medicalxpress.com
November 10, 2025 at 7:23 PM
Certain micro-RNA molecules in sperm are linked to embryo development and may help predict IVF success, offering potential for improved fertility diagnostics and treatment strategies. doi.org/g9wcvj
Reposted by Krish Sanghvi
Male-derived PBP4 is essential for sperm competition by mediating sperm motility in moths @PNAS.org
Male-derived PBP4 is essential for sperm competition by mediating sperm motility in moths
Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025.
SignificanceThis study reveals a role of pheromone-binding protein 4 (PBP4) in moth reproduction. Unlike its ancestral olfactory function, PBP4 is expressed specifically in male accessory glands (MAGs), transferred to females during mating, and enhances ...
dlvr.it
November 10, 2025 at 9:12 AM
Male-derived PBP4 is essential for sperm competition by mediating sperm motility in moths @PNAS.org
Reposted by Krish Sanghvi
How do insect wings change as bodies shrink? In this new #ProcB paper, researchers analysed wing design in 39 bark beetle species spanning a wide size range and used evolutionary models to test which features adapt quickly and which evolve slowly royalsocietypublishing.org/doi/10.1098/... #Evolution
November 10, 2025 at 11:01 AM
How do insect wings change as bodies shrink? In this new #ProcB paper, researchers analysed wing design in 39 bark beetle species spanning a wide size range and used evolutionary models to test which features adapt quickly and which evolve slowly royalsocietypublishing.org/doi/10.1098/... #Evolution
Reposted by Krish Sanghvi
A week before his defence @rug.nl, the publication of @euantheyoung.bsky.social's chapter on the lifespan cost of reproduction in @science.org Advances - with @hannahdugdale.bsky.social, @lummaalab.bsky.social and myself - couldn't have been better timed! 👍 🥳 🥂https://doi.org/10.1126/sciadv.adz6422
November 10, 2025 at 12:39 PM
A week before his defence @rug.nl, the publication of @euantheyoung.bsky.social's chapter on the lifespan cost of reproduction in @science.org Advances - with @hannahdugdale.bsky.social, @lummaalab.bsky.social and myself - couldn't have been better timed! 👍 🥳 🥂https://doi.org/10.1126/sciadv.adz6422
Reposted by Krish Sanghvi
Excited to see this huge experiment finally published!! 🪰
Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments url: academic.oup.com/evlett/artic...
Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments
Abstract. Females and males typically differ in lifespan, patterns of ageing, and reproduction. General explanations for variation in the magnitude of this
academic.oup.com
November 9, 2025 at 10:38 PM
Excited to see this huge experiment finally published!! 🪰
Reposted by Krish Sanghvi
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 9, 2025 at 11:46 PM
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Reposted by Krish Sanghvi
In a stunning display of coordinated movement, male Swallow-tailed Manakins dance together in groups of up to five to attract females. Researchers studied display consistency, group size effects and implications for female choice: royalsocietypublishing.org/doi/10.1098/... #RSOS #AnimalBehaviour
November 9, 2025 at 10:00 AM
In a stunning display of coordinated movement, male Swallow-tailed Manakins dance together in groups of up to five to attract females. Researchers studied display consistency, group size effects and implications for female choice: royalsocietypublishing.org/doi/10.1098/... #RSOS #AnimalBehaviour
Reposted by Krish Sanghvi
A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern of Drosophila melanogaster @PNAS.org
A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern of Drosophila melanogaster
Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025.
SignificanceCircadian clocks orchestrate animal behavior and physiology to anticipate and adapt to recurring events. During development, circadian clock networks increase in complexity to meet the increasing demands for signal integration and modulation ...
dlvr.it
November 8, 2025 at 9:21 PM
A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern of Drosophila melanogaster @PNAS.org
Reposted by Krish Sanghvi
Sexual selection driven by direct benefits leads to the erosion of direct benefits https://www.biorxiv.org/content/10.1101/2025.11.07.687154v1
November 8, 2025 at 2:33 AM
Sexual selection driven by direct benefits leads to the erosion of direct benefits https://www.biorxiv.org/content/10.1101/2025.11.07.687154v1
Reposted by Krish Sanghvi
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Krish Sanghvi
📖Published📖
Check out MEE's new review article 👉 Full decomposition of phenotypic variance in dichotomous traits: New methods and key implications for behaviour, demography and evolutionary ecology 🌍 🧪
buff.ly/IMsl7eL
Check out MEE's new review article 👉 Full decomposition of phenotypic variance in dichotomous traits: New methods and key implications for behaviour, demography and evolutionary ecology 🌍 🧪
buff.ly/IMsl7eL
November 7, 2025 at 12:01 PM
📖Published📖
Check out MEE's new review article 👉 Full decomposition of phenotypic variance in dichotomous traits: New methods and key implications for behaviour, demography and evolutionary ecology 🌍 🧪
buff.ly/IMsl7eL
Check out MEE's new review article 👉 Full decomposition of phenotypic variance in dichotomous traits: New methods and key implications for behaviour, demography and evolutionary ecology 🌍 🧪
buff.ly/IMsl7eL
Reposted by Krish Sanghvi
Older mice tend to have smaller offspring, with placental changes and increased oxidative stress observed primarily in male fetuses, suggesting sex-specific mechanisms may influence fetal growth. doi.org/g99c8k
Why older mice have smaller offspring—and how sex may play a role
A study by University of Manchester scientists has revealed some of the mechanisms which may explain why older mice are more likely to give birth to offspring that have not grown to their full potential in the womb.
medicalxpress.com
November 6, 2025 at 2:34 PM
Older mice tend to have smaller offspring, with placental changes and increased oxidative stress observed primarily in male fetuses, suggesting sex-specific mechanisms may influence fetal growth. doi.org/g99c8k
Reposted by Krish Sanghvi
The genetic basis of #flight capacity is more strongly linked to nervous system processes than to #wingmorphology:
doi.org/10.1093/jeb/...
Flaibani et al. #Evolution Lab (IEGEBA-CONICET) #drosophila
doi.org/10.1093/jeb/...
Flaibani et al. #Evolution Lab (IEGEBA-CONICET) #drosophila
The relationship between morphology and flight in Drosophila: a first approach to its genetic basis
Abstract. Flight is a crucial activity for winged insects, involving diverse behaviours, and wing morphology has often been proposed as a key factor influe
doi.org
November 6, 2025 at 6:01 PM
The genetic basis of #flight capacity is more strongly linked to nervous system processes than to #wingmorphology:
doi.org/10.1093/jeb/...
Flaibani et al. #Evolution Lab (IEGEBA-CONICET) #drosophila
doi.org/10.1093/jeb/...
Flaibani et al. #Evolution Lab (IEGEBA-CONICET) #drosophila
Reposted by Krish Sanghvi
Gestation length both shapes and is shaped by other life history traits in terrestrial eutherian mammals
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Thodoris Danis et al.
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Thodoris Danis et al.
Gestation length both shapes and is shaped by other life history traits in terrestrial eutherian mammals
Abstract. The length of gestation in eutherian mammals, which is key to their reproductive success, is closely connected to other life history traits, body
doi.org
November 5, 2025 at 6:47 PM
Gestation length both shapes and is shaped by other life history traits in terrestrial eutherian mammals
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Thodoris Danis et al.
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Thodoris Danis et al.
Reposted by Krish Sanghvi
New findings in worms show that sensory cues like touch can reduce the longevity benefits of dietary restriction by altering gene expression, offering insights into potential pathways for healthy aging. doi.org/g989s6
Insights from worms could help scientists harness the power of dietary restriction for longevity
The pursuit of a longer life may currently be trending for tech bros, but the notion of a fountain of youth, or even immortality, has intrigued people for millennia.
medicalxpress.com
November 5, 2025 at 8:45 PM
New findings in worms show that sensory cues like touch can reduce the longevity benefits of dietary restriction by altering gene expression, offering insights into potential pathways for healthy aging. doi.org/g989s6
Reposted by Krish Sanghvi
High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation https://www.biorxiv.org/content/10.1101/2025.11.04.686622v1
November 5, 2025 at 8:32 AM
High-resolution mapping of a rapidly evolving complex trait reveals genotype-phenotype stability and an unpredictable genetic architecture of adaptation https://www.biorxiv.org/content/10.1101/2025.11.04.686622v1
Reposted by Krish Sanghvi
Parental care, and more complex cooperative systems of care, have independently evolved in hundreds of animal lineages. In an article published today, we explore how these behaviors evolve 𝘢𝘵 𝘢 𝘮𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘭𝘦𝘷𝘦𝘭l shorturl.at/g5OPw /1
Convergent evolution of a conserved molecular network underlies parenting and sociality - Nature Reviews Genetics
Kay et al. review evidence that parental care, and more complex social behaviour based on parental care, evolved in multiple species through the repeated co-option of members of a pleiotropic molecula...
shorturl.at
November 4, 2025 at 3:57 PM
Parental care, and more complex cooperative systems of care, have independently evolved in hundreds of animal lineages. In an article published today, we explore how these behaviors evolve 𝘢𝘵 𝘢 𝘮𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘭𝘦𝘷𝘦𝘭l shorturl.at/g5OPw /1
Reposted by Krish Sanghvi
How does a single cuckoo species evolve eggs that mimic those of many different hosts?
In a new Science study, researchers report genomic data that reveal a complex geographic mosaic of cuckoo-host coevolution.
Learn more in a new #SciencePerspective: https://scim.ag/4nEZIfY
In a new Science study, researchers report genomic data that reveal a complex geographic mosaic of cuckoo-host coevolution.
Learn more in a new #SciencePerspective: https://scim.ag/4nEZIfY
November 5, 2025 at 2:26 PM
How does a single cuckoo species evolve eggs that mimic those of many different hosts?
In a new Science study, researchers report genomic data that reveal a complex geographic mosaic of cuckoo-host coevolution.
Learn more in a new #SciencePerspective: https://scim.ag/4nEZIfY
In a new Science study, researchers report genomic data that reveal a complex geographic mosaic of cuckoo-host coevolution.
Learn more in a new #SciencePerspective: https://scim.ag/4nEZIfY
Reposted by Krish Sanghvi
Temperature effects on reproductive and life-history traits in Drosophila (Diptera: Drosophilidae): a systematic map https://www.biorxiv.org/content/10.1101/2025.11.03.686415v1
November 5, 2025 at 2:32 PM
Temperature effects on reproductive and life-history traits in Drosophila (Diptera: Drosophilidae): a systematic map https://www.biorxiv.org/content/10.1101/2025.11.03.686415v1
Reposted by Krish Sanghvi
Super cool new use of single gamete (single molecule!) genome sequencing - catching de novo mobile element insertions! www.biorxiv.org/content/10.1...
Direct identification of de novo mobile element insertions from single molecule sequencing of human sperm
Mobile element insertions (MEIs) are a significant source of human genetic variation, yet the rates and properties of de novo MEIs are poorly characterized due to technical limitations in sequencing t...
www.biorxiv.org
November 5, 2025 at 4:42 PM
Super cool new use of single gamete (single molecule!) genome sequencing - catching de novo mobile element insertions! www.biorxiv.org/content/10.1...
Reposted by Krish Sanghvi
Sexually antagonistic co-evolution at the molecular level predicts phenotypic outcomes of mating interactions. https://www.biorxiv.org/content/10.1101/2025.11.04.686516v1
November 5, 2025 at 3:32 PM
Sexually antagonistic co-evolution at the molecular level predicts phenotypic outcomes of mating interactions. https://www.biorxiv.org/content/10.1101/2025.11.04.686516v1
Reposted by Krish Sanghvi
A mammals-wide study found no support for Rensch’s rule, a commonly-tested ecological rule that posits that sexual size dimorphism is greater in larger species if males are larger, and in smaller species if females are larger.
Read now ahead of print!
www.journals.uchicago.edu/doi/10.1086/...
Read now ahead of print!
www.journals.uchicago.edu/doi/10.1086/...
University of Chicago Press Journals: Cookie absent
www.journals.uchicago.edu
November 5, 2025 at 5:59 PM
A mammals-wide study found no support for Rensch’s rule, a commonly-tested ecological rule that posits that sexual size dimorphism is greater in larger species if males are larger, and in smaller species if females are larger.
Read now ahead of print!
www.journals.uchicago.edu/doi/10.1086/...
Read now ahead of print!
www.journals.uchicago.edu/doi/10.1086/...
Reposted by Krish Sanghvi
1/ Evolutionary trade-offs between intergenerational and transgenerational fitness effects
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
November 5, 2025 at 12:18 PM
1/ Evolutionary trade-offs between intergenerational and transgenerational fitness effects
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Transgenerational / intergeneration fitness effects can be adaptive, but they can also trade-off with each other:
New work led by Isaac Harris, preprint:
tinyurl.com/yp2b6tjm
Reposted by Krish Sanghvi
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutati...
www.biorxiv.org
November 4, 2025 at 6:17 PM
Transposon Regulation in the Caenorhabditis elegans Germline and Soma
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...