Joao Pedro Magalhaes
@jpsenescence.bsky.social
Scientist decoding the aging genome, professor, geek, entrepreneur, speaker, writer, keen footballer.
Reposted by Joao Pedro Magalhaes
Integrative transcriptomic identification of cellular senescence beyond marker limitations
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Integrative transcriptomic identification of cellular senescence beyond marker limitations
Cellular senescence lacks a universal marker and varies across cell types, tissues, and stressors, complicating identification. Using SPiDER SA-β-gal labeled single-cell RNA-seq from regenerating mous...
www.biorxiv.org
January 5, 2026 at 11:05 PM
Integrative transcriptomic identification of cellular senescence beyond marker limitations
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Wow, an accelerated aging syndrome in the long-lived naked mole-rat!
This was not on my bingo card for 2026 🤯
This was not on my bingo card for 2026 🤯
Progeroid Syndrome with Signs of Autophagy Dysfunction in the Naked Mole Rat (Heterocephalus glaber)
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Progeroid Syndrome with Signs of Autophagy Dysfunction in the Naked Mole Rat (Heterocephalus glaber) - Biochemistry (Moscow)
Abstract The naked mole rat is considered a unique non-aging mammalian species and is widely used in laboratories to study the biology of longevity. Previously, our group was the first to describe a n...
link.springer.com
January 3, 2026 at 5:37 PM
Wow, an accelerated aging syndrome in the long-lived naked mole-rat!
This was not on my bingo card for 2026 🤯
This was not on my bingo card for 2026 🤯
Northern Portugal is beautiful ❤️
January 2, 2026 at 9:50 PM
Northern Portugal is beautiful ❤️
Reposted by Joao Pedro Magalhaes
Codon bias coevolves with longevity
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Codon bias coevolves with longevity
Somatic mutations drive carcinogenesis and aging, shortening the lifespan of animals. Since the vulnerability of genes strongly depends on their size and the abundance of mutation hotspots, we have te...
www.biorxiv.org
January 1, 2026 at 7:58 PM
Codon bias coevolves with longevity
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Great study on the aging transcriptome.
Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging.
So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.
Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging.
So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.
The aging transcriptome: a condition-dependent response to a deteriorating soma
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
The aging transcriptome: a condition-dependent response to a deteriorating soma
Organismal function requires precise gene expression, as deviations reduce fitness and can cause disease. The widespread expression changes characteristic of old age therefore suggests that aging itse...
www.biorxiv.org
December 30, 2025 at 7:32 PM
Great study on the aging transcriptome.
Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging.
So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.
Their results suggest that, in flies, many age-related gene expression changes likely mitigate rather than accelerate aging.
So, many age-related epigenetic and transcriptional changes may be responses to aging and therefore protective.
Reposted by Joao Pedro Magalhaes
Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology
academic.oup.com/emph/advance...
academic.oup.com/emph/advance...
Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology
Abstract. Comparative phylogenetics provides a wealth of computational tools to understand evolutionary processes and their outcomes. Advances in these met
academic.oup.com
December 29, 2025 at 3:23 PM
Leveraging Comparative Phylogenetics for Evolutionary Medicine: Applications to Comparative Oncology
academic.oup.com/emph/advance...
academic.oup.com/emph/advance...
Reposted by Joao Pedro Magalhaes
Prediction and analysis of anti-aging peptides using data augmentation and machine learning algorithms
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Prediction and analysis of anti-aging peptides using data augmentation and machine learning algorithms - BMC Biology
Background For most species, Aging is an inevitable biological process that poses significant challenges to global healthcare due to age-related diseases. Recent advances in peptide therapy have highl...
link.springer.com
December 27, 2025 at 10:06 PM
Prediction and analysis of anti-aging peptides using data augmentation and machine learning algorithms
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Joao Pedro Magalhaes
Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila - npj Aging
npj Aging - Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila
www.nature.com
December 26, 2025 at 11:02 PM
Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joao Pedro Magalhaes
Blood aging: From definition and mechanisms to clinical practice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Blood aging: From definition and mechanisms to clinical practice
It is generally believed that hematopoietic aging is a major driver or contributor of human aging. The hematopoietic system undergoes physiological or…
www.sciencedirect.com
December 24, 2025 at 11:26 PM
Blood aging: From definition and mechanisms to clinical practice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Joao Pedro Magalhaes
Do we actually need aging clocks?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Do we actually need aging clocks? - npj Aging
npj Aging - Do we actually need aging clocks?
www.nature.com
December 23, 2025 at 3:51 PM
Do we actually need aging clocks?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joao Pedro Magalhaes
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies - Nature Communications
Accumulation of senescent cells is associated with age-related diseases. Here, the authors present a prodrug nanoplatform to trigger ferroptosis specifically and exclusively in senescent cells.
www.nature.com
December 21, 2025 at 10:55 PM
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Vadim was a wonderful colleague and scientist.
We collaborated on several projects, including on our aging-related databases GenAge and CellAge.
His passing is a great loss, both personally and to our scientific community.
He will be deeply missed.
We collaborated on several projects, including on our aging-related databases GenAge and CellAge.
His passing is a great loss, both personally and to our scientific community.
He will be deeply missed.
Vadim Fraifeld: Researcher, Philosopher, Dreamer
aging-longevity.org.ua/index.php/jo...
aging-longevity.org.ua/index.php/jo...
Vadim Fraifeld: Researcher, Philosopher, Dreamer
| Ageing and Longevity
aging-longevity.org.ua
December 20, 2025 at 7:27 PM
Vadim was a wonderful colleague and scientist.
We collaborated on several projects, including on our aging-related databases GenAge and CellAge.
His passing is a great loss, both personally and to our scientific community.
He will be deeply missed.
We collaborated on several projects, including on our aging-related databases GenAge and CellAge.
His passing is a great loss, both personally and to our scientific community.
He will be deeply missed.
I've just set up my out-of-office reply for the holidays.
Which means I can finally work on all the manuscripts and projects I've been postponing during the year.
Which means I can finally work on all the manuscripts and projects I've been postponing during the year.
December 19, 2025 at 7:04 PM
I've just set up my out-of-office reply for the holidays.
Which means I can finally work on all the manuscripts and projects I've been postponing during the year.
Which means I can finally work on all the manuscripts and projects I've been postponing during the year.
Reposted by Joao Pedro Magalhaes
More than one species of the naked mole-rat, a new biomedical model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
More than one species of the naked mole-rat, a new biomedical model - Communications Biology
Genomic and morphological data reveal that the naked mole-rat comprises three deeply diverged lineages, including the revalidated species Heterocephalus phillipsi, reshaping our understanding of its e...
www.nature.com
December 17, 2025 at 8:00 PM
More than one species of the naked mole-rat, a new biomedical model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Joao Pedro Magalhaes
Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers
Many biological processes, including cellular senescence, manifest as diverse phenotypes that vary across cell types and conditions. In the absence of single, definitive markers, researchers often rel...
www.biorxiv.org
December 16, 2025 at 4:12 PM
Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joao Pedro Magalhaes
A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility
Biological brain ageing is a major risk factor for neurodegenerative diseases, which are characterized by selective degeneration of particular neuron types. We analyzed the impact of ageing on the tra...
www.biorxiv.org
December 13, 2025 at 11:53 PM
A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Joao Pedro Magalhaes
RNA degradation modulates unique aging-related gene expression in naked mole-rats
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RNA degradation modulates unique aging-related gene expression in naked mole-rats
Gene expression is co-regulated by the rates of RNA synthesis and degradation, and recent evidence has linked their imbalance to the onset of aging. The naked mole-rat (NMR) is a small rodent with an ...
www.biorxiv.org
December 11, 2025 at 8:37 PM
RNA degradation modulates unique aging-related gene expression in naked mole-rats
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Aging As a Software Design Flaw
What if ageing is not an accumulation of molecular damage to the hardware, but a process driven by our developmental software program?
Great explainer video by Aleksey Belikov using NotebookLM.
www.youtube.com/watch?v=Hqxe...
What if ageing is not an accumulation of molecular damage to the hardware, but a process driven by our developmental software program?
Great explainer video by Aleksey Belikov using NotebookLM.
www.youtube.com/watch?v=Hqxe...
Aging As a Software Design Flaw
YouTube video by Joao Pedro Magalhaes
www.youtube.com
December 11, 2025 at 12:01 AM
Aging As a Software Design Flaw
What if ageing is not an accumulation of molecular damage to the hardware, but a process driven by our developmental software program?
Great explainer video by Aleksey Belikov using NotebookLM.
www.youtube.com/watch?v=Hqxe...
What if ageing is not an accumulation of molecular damage to the hardware, but a process driven by our developmental software program?
Great explainer video by Aleksey Belikov using NotebookLM.
www.youtube.com/watch?v=Hqxe...
Reposted by Joao Pedro Magalhaes
Atavistic Genetic Expression Dissociation (AGED) During Aging: Meta-Phylostratigraphic Evidence of Cellular and Tissue-Level Phylogenetic Dissociation
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Atavistic Genetic Expression Dissociation (AGED) During Aging: Meta‐Phylostratigraphic Evidence of Cellular and Tissue‐Level Phylogenetic Dissociation
Aging represents an atavistic over-representation of differential expression in the most ancient genes and under-representation in the evolutionary youngest genes for two multi-tissue aging databases....
onlinelibrary.wiley.com
December 9, 2025 at 10:02 PM
Atavistic Genetic Expression Dissociation (AGED) During Aging: Meta-Phylostratigraphic Evidence of Cellular and Tissue-Level Phylogenetic Dissociation
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Joao Pedro Magalhaes
Hematopoietic (stem) cells—The elixir of life?
febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the hear...
febs.onlinelibrary.wiley.com
December 8, 2025 at 3:24 PM
Hematopoietic (stem) cells—The elixir of life?
febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Joao Pedro Magalhaes
Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation - Mobile DNA
Nearly half of the human genome consists of transposable elements, among which endogenous retroviruses, remnants of ancient retroviral infections, represent some of the most evolutionarily intriguing ...
link.springer.com
December 6, 2025 at 6:51 PM
Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Wow, Retro Bio is raising $1B on a $5B valuation 🤯
Aging startup Retro Bio chases $5 billion valuation
www.statnews.com/2025/12/03/a...
www.statnews.com/2025/12/03/a...
Aging startup backed by Sam Altman chases $5 billion valuation
Retro Bio, a longevity startup backed by OpenAI CEO Sam Altman, is close to raising what could be one of the drug industry’s largest investment rounds.
www.statnews.com
December 5, 2025 at 12:42 AM
Wow, Retro Bio is raising $1B on a $5B valuation 🤯
Reposted by Joao Pedro Magalhaes
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects - Russian Journal of Genetics
Abstract The review examines modern advances in the genetics of aging and life span. The key molecular mechanisms regulating aging processes at the genetic level are analyzed, including signaling path...
link.springer.com
December 2, 2025 at 4:49 PM
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects
link.springer.com/article/10.1...
link.springer.com/article/10.1...
New methodological appraisal of the DrugAge database of longevity drugs 💊
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database - npj Aging
npj Aging - Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database
www.nature.com
November 29, 2025 at 6:45 PM
New methodological appraisal of the DrugAge database of longevity drugs 💊
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Our analysis of 667 anti-ageing studies shows poor reporting, big species differences, and limited translation to mammals.
Work led by Austin Parish with many great collaborators.
www.nature.com/articles/s41...
Reposted by Joao Pedro Magalhaes
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...
Why we age is still longevity’s biggest question
Aging researcher expands on how addressing 100 key problems can provide the field with a roadmap for future investigation.
longevity.technology
November 27, 2025 at 6:49 PM
Why we age is still longevity’s biggest question
longevity.technology/news/why-we-...
longevity.technology/news/why-we-...