Corey
@kh0rish.bsky.social
Biologist, just fed up at this point because *gestures everywhere*
Pinned
Corey
@kh0rish.bsky.social
· Aug 29
So first, we gotta start digging into biochemistry, BUT, we have to treat biochemistry like the finite-state machinery that it is. And not the abstract mathematical concept, but the simple machines of physics (lever, pulley, screw, etc) to form active mechanisms like this lock:
![An example of a simple mechanism that can be modeled by a state machine is a turnstile.[4][5] A turnstile, used to control access to subways and amusement park rides, is a gate with three rotating arms at waist height, one across the entryway. Initially the arms are locked, blocking the entry, preventing patrons from passing through. Depositing a coin or token in a slot on the turnstile unlocks the arms, allowing a single customer to push through. After the customer passes through, the arms are locked again until another coin is inserted.
Considered as a state machine, the turnstile has two possible states: Locked and Unlocked.[4] There are two possible inputs that affect its state: putting a coin in the slot (coin) and pushing the arm (push). In the locked state, pushing on the arm has no effect; no matter how many times the input push is given, it stays in the locked state. Putting a coin in – that is, giving the machine a coin input – shifts the state from Locked to Unlocked. In the unlocked state, putting additional coins in has no effect; that is, giving additional coin inputs does not change the state. A customer pushing through the arms gives a push input and resets the state to Locked.
The turnstile state machine can be represented by a state-transition table, showing for each possible state, the transitions between them (based upon the inputs given to the machine) and the outputs resulting from each input:
The turnstile state machine can also be represented by a directed graph called a state diagram (above). Each state is represented by a node (circle). Edges (arrows) show the transitions from one state to another. Each arrow is labeled with the input that triggers that transition. An input that doesn't cause a change of state (such as a coin input in the Unlocked state) is represented by a circular arrow returning to the original state. The arrow into the Locked node from the black dot indicates it is the initial state.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:v2ro4utbnjevjbvwhxz3mmyb/bafkreicdj6pzxhfq7hy64myavnbs6bgm3metwjk3o74no4w4cq3cb2qygy@jpeg)
Blows my mind how much people are still trying to use a statistical model of word proximity to do things they would NEVER try to do with something explicitly stated to be a statistical model of proximity.
February 10, 2026 at 4:22 PM
Blows my mind how much people are still trying to use a statistical model of word proximity to do things they would NEVER try to do with something explicitly stated to be a statistical model of proximity.
He can't be serious.
Embarrassing.
Embarrassing.
February 10, 2026 at 4:15 PM
He can't be serious.
Embarrassing.
Embarrassing.
Reposted by Corey
It took me longer than it should have to realize that tech companies hire people with advanced degrees in part to give a patina of scientistic rigor to their shady practices. Many of these same companies donated to Trump's inauguration fund, donating to the admin's attack on education and research
“She compares her work to the efforts of a parent raising a child. She’s training Claude to detect the difference between right and wrong while imbuing it with unique personality traits.”
This Philosopher Is Teaching AI to Have Morals
The tech company has entrusted the philosopher to endow its chatbot with a sense of right and wrong.
www.wsj.com
February 9, 2026 at 6:42 PM
It took me longer than it should have to realize that tech companies hire people with advanced degrees in part to give a patina of scientistic rigor to their shady practices. Many of these same companies donated to Trump's inauguration fund, donating to the admin's attack on education and research
Reposted by Corey
AI "impedes [theory because we're] interested in human-understandable theory and theory-based models, not statistical models which provide only a representation of the data. Scientific theories and models are only useful if [we understand them and] they connect transparently to research questions."
Not directly relevant but medicalisation is also a strategy, perhaps useful see bsky.app/profile/oliv...
February 8, 2026 at 7:33 AM
AI "impedes [theory because we're] interested in human-understandable theory and theory-based models, not statistical models which provide only a representation of the data. Scientific theories and models are only useful if [we understand them and] they connect transparently to research questions."
Reposted by Corey
No, brain is nothing like a computer, or to put it other way, a computer is nothing like a brain.
A lot to #Unlearn from 20th-century thinking.
"Smuggles confidence into biology, where change is slower, messier and often incomplete"
aeon.co/essays/what-...
A lot to #Unlearn from 20th-century thinking.
"Smuggles confidence into biology, where change is slower, messier and often incomplete"
aeon.co/essays/what-...
What the metaphor of ‘rewiring’ gets wrong about neuroplasticity | Aeon Essays
The metaphor of rewiring offers an ideal of engineered precision. But the brain is more like a forest than a circuit board
aeon.co
February 7, 2026 at 3:04 PM
No, brain is nothing like a computer, or to put it other way, a computer is nothing like a brain.
A lot to #Unlearn from 20th-century thinking.
"Smuggles confidence into biology, where change is slower, messier and often incomplete"
aeon.co/essays/what-...
A lot to #Unlearn from 20th-century thinking.
"Smuggles confidence into biology, where change is slower, messier and often incomplete"
aeon.co/essays/what-...
It says everything really
Yes, but it is kind of saying something that a human on the other side of the world, with absolutely no additional input but the same sensors and data the AI has access to on a screen, solves problem the AI does not.
February 6, 2026 at 4:08 PM
It says everything really
“Why do you want to play an MMO if you just want to play solo all the time”
Because parallel play is a thing dummy. I like having yall around but Im not getting caught up in your ultra competitive minmaxxing nonsense I dont have time for that shit
Because parallel play is a thing dummy. I like having yall around but Im not getting caught up in your ultra competitive minmaxxing nonsense I dont have time for that shit
February 5, 2026 at 10:52 PM
“Why do you want to play an MMO if you just want to play solo all the time”
Because parallel play is a thing dummy. I like having yall around but Im not getting caught up in your ultra competitive minmaxxing nonsense I dont have time for that shit
Because parallel play is a thing dummy. I like having yall around but Im not getting caught up in your ultra competitive minmaxxing nonsense I dont have time for that shit
The breaking of brains sometimes when people find out Im married and childfree by (permanent) choice but also great with kids and actually like them.
February 5, 2026 at 10:10 PM
The breaking of brains sometimes when people find out Im married and childfree by (permanent) choice but also great with kids and actually like them.
Reposted by Corey
Is it the same circle of people who say Musk stole the election via voting machines because they can’t admit that America is very racist and sexist and that people not voting because Bernie was better made a difference?
February 5, 2026 at 7:21 AM
Is it the same circle of people who say Musk stole the election via voting machines because they can’t admit that America is very racist and sexist and that people not voting because Bernie was better made a difference?
Reposted by Corey
For those who wonder:
We see the assembly of a cell's skeleton, a dynamic structure that gives cells their shape, like a sticks would do inside a plastic bag.
The fluorescence in the video is emitted at the tips of microtubules where & when elementar bricks are being added onto the growing fibers.
We see the assembly of a cell's skeleton, a dynamic structure that gives cells their shape, like a sticks would do inside a plastic bag.
The fluorescence in the video is emitted at the tips of microtubules where & when elementar bricks are being added onto the growing fibers.
February 5, 2026 at 12:10 PM
For those who wonder:
We see the assembly of a cell's skeleton, a dynamic structure that gives cells their shape, like a sticks would do inside a plastic bag.
The fluorescence in the video is emitted at the tips of microtubules where & when elementar bricks are being added onto the growing fibers.
We see the assembly of a cell's skeleton, a dynamic structure that gives cells their shape, like a sticks would do inside a plastic bag.
The fluorescence in the video is emitted at the tips of microtubules where & when elementar bricks are being added onto the growing fibers.
Reposted by Corey
An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.
February 5, 2026 at 5:27 AM
An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.
Reposted by Corey
Also the kind of work above always assumes "artificial cognition" exists and then they keep going in circles claiming they found evidence for the thing they assumed. Not how any of this works...
February 5, 2026 at 4:36 AM
Also the kind of work above always assumes "artificial cognition" exists and then they keep going in circles claiming they found evidence for the thing they assumed. Not how any of this works...
My elders and *recent* ancestors went through far worse. Dooming dishonors their sacrifices. They didnt die for this.
Some peoples privilege really reeks of babyshit. Stand the fuck up
Some peoples privilege really reeks of babyshit. Stand the fuck up
Too many people on Bluesky think that relentless expressions of despair are a sign of intellectual sophistication.
February 5, 2026 at 3:00 AM
My elders and *recent* ancestors went through far worse. Dooming dishonors their sacrifices. They didnt die for this.
Some peoples privilege really reeks of babyshit. Stand the fuck up
Some peoples privilege really reeks of babyshit. Stand the fuck up
NEVER BACK DOWN, NEVER WHAT?
Not enough. Every single ICE and CBP agent should be out of Minnesota. The terror campaign must stop.
ICE must be abolished.
ICE must be abolished.
February 5, 2026 at 2:17 AM
NEVER BACK DOWN, NEVER WHAT?
Ayo what the fuck?
February 2, 2026 at 5:22 AM
Ayo what the fuck?
My friend had the best baby reveal of all time. All us guys (friends since high school) got together for some korean bbq and ordered soju. It had been a while since we all got to hang out so we loaded up some shots. He snuck the sonogram onto the spot we were setting the glasses down. Core memory
February 1, 2026 at 11:39 PM
My friend had the best baby reveal of all time. All us guys (friends since high school) got together for some korean bbq and ordered soju. It had been a while since we all got to hang out so we loaded up some shots. He snuck the sonogram onto the spot we were setting the glasses down. Core memory
Reposted by Corey
So many people - even Google engineers - were saying that if Google was doing this, surely some engineers would leak it. No, turns out an L3 salary is enough to pay most people off.
February 1, 2026 at 10:32 PM
So many people - even Google engineers - were saying that if Google was doing this, surely some engineers would leak it. No, turns out an L3 salary is enough to pay most people off.
Im still geekin from “suffer-oth” 😂😂
suffer-oth maybe
sephiroth was interesting and played an important character roll
this is just failing at masturbation with extra steps
sephiroth was interesting and played an important character roll
this is just failing at masturbation with extra steps
February 1, 2026 at 9:40 PM
Im still geekin from “suffer-oth” 😂😂
Wondering if dog licks are less “kisses” and more “i dont have hands so this is how i pet you back”
February 1, 2026 at 6:49 PM
Wondering if dog licks are less “kisses” and more “i dont have hands so this is how i pet you back”
Reposted by Corey
“Emergence” = Something happened I dont fully understand so instead of properly investigating Im going to use a catchall term for “and then *MAGIC* happens”
February 1, 2026 at 5:24 PM
“Emergence” = Something happened I dont fully understand so instead of properly investigating Im going to use a catchall term for “and then *MAGIC* happens”
Reposted by Corey
What *has* happened somewhat more recently is that we have come to understand that even more of the noncoding DNA is important than we thought. Some of it gets transcribed into non-coding RNA that isn’t then translated into proteins. /6
January 30, 2026 at 9:50 AM
What *has* happened somewhat more recently is that we have come to understand that even more of the noncoding DNA is important than we thought. Some of it gets transcribed into non-coding RNA that isn’t then translated into proteins. /6
Reposted by Corey
Epstein’s economic power among academics was made possible by a capitalist system that makes higher education dependent on the charity economy rather than a public good supported by taxing the rich
February 1, 2026 at 2:33 PM
Epstein’s economic power among academics was made possible by a capitalist system that makes higher education dependent on the charity economy rather than a public good supported by taxing the rich
Yo fuck all the way off with this one because this is some of the most ghoulish bullshit i have ever seen. “Tech” is just glorified advertising delivery and thats truly a pathetic waste of resources and human effort/minds
Folks have joked about this, but some people making these bots have actually considered it—targeted ads from your dead relative or loved one.
February 1, 2026 at 3:59 PM
Yo fuck all the way off with this one because this is some of the most ghoulish bullshit i have ever seen. “Tech” is just glorified advertising delivery and thats truly a pathetic waste of resources and human effort/minds