Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!

Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.

Excited to announce that a new protocol to test potential PD-1/PD-L1 inhibitors was recently published by my former lab at URI. I’m happy to have contributed to this method to determine drug candidates’ ability to block this pathway, commonly exploited by cancer cells to hide from the immune system.

A new call to revise the limit to culture human embryos, currently not allowed beyond 14 days (start of gastrulation) to 28 days www.nature.com/articles/d41....
There is no new argument here to add to earlier calls but, as often in this argument, certain caveats are glossed over….. . 🧵

The decades-old limit on how long human embryos can be grown in culture is under debate

https://go.nature.com/448yuYw

In a follow-up to our recent coverage of the NIH, our latest piece talks about the NSF’s role in funding basic science in the U.S. and how that role is being threatened by restructuring, budget cuts, and cuts to training programs and fellowships like REUs and the GRFP. Read about it here: 🧪 #scicomm

What does real inclusion look like in biology? 🌈 Join Dr. Katelyn Cooper, Associate Professor at Arizona State University, on June 18 for a free webinar: Inclusive Illusions: LGBTQ+ Realities in the Biological Sciences 🔗 www.ascb.org/ascb.../incl...
#STEMdiversity #LGBTQinSTEM #ASCB #CellBiology

A great highlight of some really important research. It reminds me of another article I read a few months ago from @ascbiology.bsky.social about how open you should be with your identity when applying to academic jobs (www.ascb.org/diversity-eq...). All three works are definitely worth reading.

Who “belongs” in biology?

The first comprehensive analysis of the LGBTQ+ climate in the biological sciences! #LGBTinSTEM #preprint 🏳️‍🌈

#preLight prepared by @ryanharrison13.bsky.social, Stefan & @reinierprosee.bsky.social ⬇️👀
prelights.biologists.com/highlights/l...

Happy Pride Month, shoalmates! 🏳️‍🌈 🏳️‍⚧️🐟 Our own Danny-O the #zebrafish is rockin’ the rainbow guitar this month 💪 #NewProfilePic

Choking under pressure? 🥵

3D confinement in hydrogel-based culture inhibits muscle stem cell activation and differentiation.

“…this #preprint demonstrates the interconnectedness of different subfields of biology.”

#preLight of @justingutbio.bsky.social ⬇️👀
prelights.biologists.com/highlights/3...

Excited to announce I just posted a new preLight showcasing the work of @thegaaa.bsky.social in the lab of @thewooj.bsky.social on the effects of 3D confinement on muscle stem cell proliferation and differentiation using an asymmetric hydrogel bilayer model. Check out the post and their paper below:

In this very cool 1-2 punch from the Weinstein lab, start by reading Miranda & co’s awesome pre-print about a novel epigenetic reporter and follow it up with @jimmykjm.bsky.social’s pre-print using it to characterize epigenetic reprogramming during fin regeneration: www.biorxiv.org/content/10.1...

preLights in developmental biology (February 2025)

This article lists the recent posts @prelights.bsky.social that discuss #preprints in #DevBio and #StemCells. Featured #preLight by @justingutbio.bsky.social, covering a #preprint on germplasm stability from the lab of @reneketting.bsky.social.

Excited to announce I joined @prelights.bsky.social and wrote my first post for them! Looking forward to covering more cool science in the future.