Joel Selkrig
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jselkrig.bsky.social
Joel Selkrig
@jselkrig.bsky.social
Updates from the Selkrig Lab. Exploring the function of secreted bacterial proteins in the context of infection and the gut microbiome.

www.ukaachen.de/kliniken-institute/institut-fuer-medizinische-mikrobiologie/forschung/ag-selkrig/
Reposted by Joel Selkrig
This is such hard news to process. Such an amazing scientist and inspiration for so many of us.
www.embl.org/news/embl-an...
In remembrance of Peer Bork  | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
www.embl.org
January 16, 2026 at 6:01 PM
Reposted by Joel Selkrig
20 | Peer Bork and the scientific candy shop
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/17ux...
20 | Peer Bork and the scientific candy shop
Podcast Episode · Night Science · 09/02/2022 · 29m
podcasts.apple.com
January 18, 2026 at 12:52 AM
Reposted by Joel Selkrig
Peer Bork died yesterday 💔 which shocked me. In 2003 I did a short-term fellowship in Peer’s lab because I idolized him. I met Martin there & we wrote this paper together. Peer was great at bringing people together; a master collaborator with a rare ability to think up big ideas.
January 18, 2026 at 12:52 AM
Reposted by Joel Selkrig
Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.

It’s not a toxin. It’s metabolism.

The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.

doi.org/10.1126/sciadv.aeb5297
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.
doi.org
January 17, 2026 at 5:57 AM
Reposted by Joel Selkrig
📢 We are hiring 📢 1st round of recruiting for our ERC project BacImmune-Decode! @erc.europa.eu
We are looking for a postdoc for wet-lab work on regulation of phage defence systems in bacteria using high-throughput microbial genetics. Check it out: lnkd.in/es7AE968
#Hiring #Postdoc #Microbiology
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
January 14, 2026 at 8:55 AM
Reposted by Joel Selkrig
Mark your calendars for a new round of @globalimmuno.bsky.social !
Honored and excited to be part of the lineup this year!
2026 is here! We’re excited to share Global Immunotalks first semester poster, featuring an outstanding lineup!

Please share and help us spread the word!
January 12, 2026 at 9:54 PM
Reposted by Joel Selkrig
RIL-seq boosts the study of sRNAs. Here comes its first application to intracellular bacteria. Plus, 10 years after its characterization, we now present an RNA sponge of Salmonella PinT.
Congrats to @kooshapour.bsky.social & great collaboration w/ @jorg-vogel-lab.bsky.social!
doi.org/10.1093/nar/...
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT
Abstract. Salmonella virulence chiefly relies upon two major pathogenicity islands, SPI-1 and SPI-2, which enable host cell invasion and intracellular surv
doi.org
December 27, 2025 at 2:06 PM
Reposted by Joel Selkrig
We’re hiring 2 Postdocs (f/m/d) in Drug–Microbiome–Host Interactions 🦠💊

Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.

#PostdocJobs #Microbiome #AcademicJobs

Full job ad:
lisamaierlab.com/wp-content/u...
lisamaierlab.com
December 22, 2025 at 2:08 PM
Reposted by Joel Selkrig
New preprint from the lab is out! 🥳

We systematically profiled all pairwise growth interactions between 36 representative human gut microbiome strains, and delved deeper into the molecular mechanisms behind specific growth interactions.

www.biorxiv.org/content/10.6...

👇
Systematic profiling of growth interactions in human gut microbiome species
Microbial interactions shape the composition and stability of the human gut microbiome. Yet, the molecular mechanisms underlying these relationships remain poorly understood. Here, we systematically p...
www.biorxiv.org
December 22, 2025 at 11:21 AM
Reposted by Joel Selkrig
🚨PhD position alert🚨

🔬Cryo-EM? ✅ 🧫Membrane proteins? - we've got 165 TMs for you! ✅

Join me and the team👥 in beautiful Amsterdam🚴 to untangle the amazing mycobacterial protein secretion machinery!

📝Apply here: tinyurl.com/mmxnfpnw

📆Deadline: 23 January

#PhDstudent #T7SS #cryoEM #newPI
Vacature — PhD candidate; Mechanism and assembly of type VII secretion system machineries
We are looking for an enthusiastic and motivated PhD candidate to join Dr. Catalin Bunduc’s team in the Molecular Microbiology Section of the Amsterdam Institute for Life and Environment (A-LIFE).
tinyurl.com
December 12, 2025 at 3:06 PM
Reposted by Joel Selkrig
Congratulations, Julia Mahamid!

Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology!

#LeibnizPreis
Und hier sind sie – die 10 Preisträger*innen des Gottfried Wilhelm #LeibnizPreis' 2026 – ausgezeichnet für ihre exzellenten Forschungsarbeiten und Errungenschaften in der Wissenschaft! 🏆👏
Die Verleihung der Preise feiern wir am 18. März in Berlin.
Einzelheiten & Kurzprofile: sohub.io/1uv1
December 11, 2025 at 10:12 AM
Reposted by Joel Selkrig
🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
Reposted by Joel Selkrig
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
December 9, 2025 at 10:33 AM
Reposted by Joel Selkrig
I couldn’t be happier or more flattered to receive an ERC-CoG. I’m grateful for this opportunity and excited to take the next steps in our research!
Recruiting early next year! Reach out if you want find out how to use bacterial immunity to tackle infections! @erc.europa.eu @unituebingen.bsky.social
🎉 Congrats to @brochadolab.bsky.social @unituebingen.bsky.social on a €2M ERC Consolidator Grant for BacImmune-Decode, advancing our understanding of bacterial immunity to fight infections + AMR!!

More: www.cmfi.uni-tuebingen.de/en/news-even...

@erc.europa.eu
#ERC #AMR #Microbiology #ScienceNews
December 9, 2025 at 2:02 PM
Reposted by Joel Selkrig
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...
December 5, 2025 at 5:06 PM
Reposted by Joel Selkrig
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.

research.pasteur.fr/en/call/mid-...
Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...
research.pasteur.fr
November 27, 2025 at 1:38 PM
Reposted by Joel Selkrig
Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Reposted by Joel Selkrig
One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...
November 27, 2025 at 1:20 PM
Reposted by Joel Selkrig
Excited to share new work by Guli Agirman + co that identifies a direct mechanism linking gut microbial imidazole propionate to stress! 🧠🦠 Btw this image was made by Nano Banana Pro 🍌. First time I've gotten a model to accurately generate a science graphic 🤯 authors.elsevier.com/a/1mA5M6t8JE...
November 25, 2025 at 5:45 PM
Reposted by Joel Selkrig
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.

The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
Reposted by Joel Selkrig
Secreting bacteria undergo drastic changes.
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
November 24, 2025 at 10:56 PM
Reposted by Joel Selkrig
Many congratulations Teresa!

Teresa Thurston was awarded the 2025 Pettenkofer Prize, recognising her contributions to identifying how different bacterial effectors impact the outcome of infection.

www.path.ox.ac.uk/news-article...
2025 Pettenkofer Prize awarded to Teresa Thurston - Dunn School
The award by the Pettenkofer Foundation recognised Teresa’s contributions to identifying how different bacterial effectors impact the outcome of infection.
www.path.ox.ac.uk
November 21, 2025 at 3:04 PM
Reposted by Joel Selkrig
#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky 🦠💊

www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:07 PM
Reposted by Joel Selkrig
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
November 15, 2025 at 4:02 AM
Reposted by Joel Selkrig
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social

www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM