Joris Deelen
@jorisdeelen.bsky.social
Associate professor at the section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center working on the genetics of human longevity and biomarkers of healthy ageing
#genetics #biomarkers #ageing
#genetics #biomarkers #ageing
Pinned
Joris Deelen
@jorisdeelen.bsky.social
· Dec 17
I am very excited to officially announce that I will be starting my new position as associate professor ("Universitair Hoofddocent") in the section of Molecular Epidemiology, Department of Biomedical Data Sciences at the Leiden University Medical Center on the 1st of January! (1/4)
Reposted by Joris Deelen
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 9, 2025 at 11:46 PM
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Reposted by Joris Deelen
📰Weekend read!
BSRA & Dutch Society for Research on Ageing sign collaboration agreement of
1. Mutural speaker exchange
2. Reciprocal meeting benefits
3. Joint policy work
4. Joint initiatives
5. Future plans, watch this space...
Read more - bsra.org.uk/dusra-collab...
BSRA & Dutch Society for Research on Ageing sign collaboration agreement of
1. Mutural speaker exchange
2. Reciprocal meeting benefits
3. Joint policy work
4. Joint initiatives
5. Future plans, watch this space...
Read more - bsra.org.uk/dusra-collab...
Dutch Society for Research on Ageing and BSRA sign collaboration agreement - BSRA
Speaking at the launch of this collaboration between the British Society for Research on Ageing (BSRA) and the Dutch Society for Research on Ageing (DuSRA), leaders from both societies outlined their ...
bsra.org.uk
November 8, 2025 at 11:23 AM
📰Weekend read!
BSRA & Dutch Society for Research on Ageing sign collaboration agreement of
1. Mutural speaker exchange
2. Reciprocal meeting benefits
3. Joint policy work
4. Joint initiatives
5. Future plans, watch this space...
Read more - bsra.org.uk/dusra-collab...
BSRA & Dutch Society for Research on Ageing sign collaboration agreement of
1. Mutural speaker exchange
2. Reciprocal meeting benefits
3. Joint policy work
4. Joint initiatives
5. Future plans, watch this space...
Read more - bsra.org.uk/dusra-collab...
Back again after some inspiring trips to both the TWIN4EarLiStAge HorizonEU Twinning Project summer school in Heraklion and the Biomarkers of Aging Consortium meeting in Boston. Great to see so many young scientists getting interested in ageing research!
October 23, 2025 at 6:40 PM
Back again after some inspiring trips to both the TWIN4EarLiStAge HorizonEU Twinning Project summer school in Heraklion and the Biomarkers of Aging Consortium meeting in Boston. Great to see so many young scientists getting interested in ageing research!
Reposted by Joris Deelen
PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI.
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham on FindAPhD.com
PhD Project - Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
October 19, 2025 at 7:00 PM
PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI.
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
Applications are open to UK and international students.
Deadline: 27 November 2025.
www.findaphd.com/phds/project...
And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!
Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!
September 27, 2025 at 6:07 PM
And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!
Reposted by Joris Deelen
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
September 24, 2025 at 12:23 PM
Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
Reposted by Joris Deelen
🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.
tinyurl.com
September 19, 2025 at 10:53 AM
🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.
Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins.
🧪
immunityageing.biomedcentral.com/articles/10....
🧪
immunityageing.biomedcentral.com/articles/10....
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport - Immunity & Ageing
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth...
immunityageing.biomedcentral.com
September 13, 2025 at 7:37 AM
Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins.
🧪
immunityageing.biomedcentral.com/articles/10....
🧪
immunityageing.biomedcentral.com/articles/10....
Reposted by Joris Deelen
My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:
🚨 Job alert! The Fernandes Lab is looking for a postdoc (m/f/d)! Apply now!
mpi-age.de.umantis.com/Vacancies/49...
@stephalcantara.bsky.social @cecad.bsky.social
mpi-age.de.umantis.com/Vacancies/49...
@stephalcantara.bsky.social @cecad.bsky.social
September 11, 2025 at 11:19 AM
My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:
Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!
September 8, 2025 at 5:35 AM
Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!
Reposted by Joris Deelen
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Reposted by Joris Deelen
Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting!
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands
Annual meeting 2025
Welcome message from the organizing committee
In 2025, the Dutch Society for Aging Research (DuSRA) is proud to host its Annual Scientific Meeting on 10–11 November 2025 in Amsterdam.
Over two days, ...
dusra.nl
August 19, 2025 at 9:08 AM
Registration is now open! As one of the organizers, I am looking forward to meeting all the aging researchers in the Netherlands at our annual meeting!
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands
dusra.nl/annual-meeti...
#DuSRA #AmsterdamUMC #Agingresearch #Netherlands
Reposted by Joris Deelen
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
August 1, 2025 at 10:36 AM
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Reposted by Joris Deelen
Grateful to @maxplanck.de for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄
Yummy, das riecht gut! 🥘 Essensduft aktiviert bestimmte Nervenzellen in #Gehirn, die das Hungergefühl verringern. Deshalb haben wir nach dem Kochen, oft keinen #Appetit mehr. Der erste #Heißhunger ist verflogen: youtu.be/HTPll7fLl3c #Ernährung
Sättigungsgefühl durch Gerüche: Kann man sich satt riechen und Heißhunger einfach wegriechen?
YouTube video by MaxPlanckSociety
youtu.be
July 29, 2025 at 6:54 PM
Grateful to @maxplanck.de for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄
Reposted by Joris Deelen
New preprint with our list of 100 open problems in ageing science.
Our curated list captures both long-standing fundamental questions and emerging research frontiers.
A massive team effort by >30 researchers from many disciplines in biogerontology.
arxiv.org/abs/2507.18602
Our curated list captures both long-standing fundamental questions and emerging research frontiers.
A massive team effort by >30 researchers from many disciplines in biogerontology.
arxiv.org/abs/2507.18602
Open problems in ageing science: A roadmap for biogerontology
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
arxiv.org
July 28, 2025 at 7:07 PM
New preprint with our list of 100 open problems in ageing science.
Our curated list captures both long-standing fundamental questions and emerging research frontiers.
A massive team effort by >30 researchers from many disciplines in biogerontology.
arxiv.org/abs/2507.18602
Our curated list captures both long-standing fundamental questions and emerging research frontiers.
A massive team effort by >30 researchers from many disciplines in biogerontology.
arxiv.org/abs/2507.18602
Very proud of Niels van den Berg who managed to secure a prestigious Veni grant from NWO! It is really great that he can now expand his research line on socioeconomic factors influencing health within families as part of our Ageing group within @molepi.bsky.social @bds-lumc.bsky.social!
📢 Niels van den Berg has been awarded a €320,000 Veni grant from NWO for his research on how socioeconomic resources, behaviour, and genes affect health within families. Proud of Niels! 👏🥂
More info👇
www.nwo.nl/en/news/200-...
#NWO #veni #Causality #BDS-MOLEPI #LUMC #HealthCampustheHague
More info👇
www.nwo.nl/en/news/200-...
#NWO #veni #Causality #BDS-MOLEPI #LUMC #HealthCampustheHague
200 onderzoekers ontvangen Veni-beurs | NWO
Binnen jeugdbeschermingstrajecten identificeren wanneer de kans op uithuisplaatsingen van kinderen het grootst is. De kwaliteit van operaties verbeteren met videoanalyse. De wisselwerking tussen wind en vegetatie voor het optimaliseren van de weerbaarheid van kustduinen. Betrouwbare algoritmes ontwikkelen voor statistisch leren met interactieve besliskunde. Dit zijn vier van de tweehonderd onderzoeksprojecten van wetenschappers die een Veni-beurs hebben gekregen. Elke onderzoeker krijgt maximaal 320.000 euro toegewezen. De beurs is een stimulans voor avontuurlijke, talentvolle en baanbrekende onderzoekers om de komende drie jaar hun eigen onderzoeksideeën verder te ontwikkelen.
www.nwo.nl
July 17, 2025 at 8:30 PM
Very proud of Niels van den Berg who managed to secure a prestigious Veni grant from NWO! It is really great that he can now expand his research line on socioeconomic factors influencing health within families as part of our Ageing group within @molepi.bsky.social @bds-lumc.bsky.social!
Reposted by Joris Deelen
The MolEpi group congratulates Niels van den Berg with his Veni grant! 👏🥂
📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME)
👉 www.nwo.nl/en/news/200-...
#NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague
📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME)
👉 www.nwo.nl/en/news/200-...
#NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague
July 17, 2025 at 9:26 AM
The MolEpi group congratulates Niels van den Berg with his Veni grant! 👏🥂
📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME)
👉 www.nwo.nl/en/news/200-...
#NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague
📝 Title of the project: Spousal survival Advantage by Marrying into longevity Enriched families (SAME)
👉 www.nwo.nl/en/news/200-...
#NWO #veni #grant #Causality #BDS-MOLEPI #LUMC #ODDISEI #DataScience #HealthCampustheHague
Reposted by Joris Deelen
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
hireful.
tinyurl.com
July 4, 2025 at 9:51 AM
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
Reposted by Joris Deelen
One week left until the abstract submission deadline. Excellent line-up of speakers discussing diverse topics on aging and longevity and 20+ slots for short talks selected from the abstracts. Don't miss your chance to join us in Jena in September!
Interested in healthy aging - from fundamental mechanisms to advanced interventions? Join us September 24-26 for the Groningen-Jena Aging Meeting, featuring talks by leading experts and 20+ short talk slots selected from abstracts. Early bird registration ends on 30.06.25
June 22, 2025 at 5:45 PM
One week left until the abstract submission deadline. Excellent line-up of speakers discussing diverse topics on aging and longevity and 20+ slots for short talks selected from the abstracts. Don't miss your chance to join us in Jena in September!
Reposted by Joris Deelen
Online now!✨RESEARCH: Gkioni et al @mpiage.bsky.social show that trametinib and rapamycin treatment combine additively to extend lifespan and healthspan in female and male mice, reducing tumor growth and inflammation www.nature.com/articles/s43... rdcu.be/eo3gS
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan - Nature Aging
Gkioni et al. show that trametinib, which targets the Ras–Mek–Erk pathway, extends lifespan in male and female mice and that co-treatment with the known geroprotector rapamycin additively extends life...
www.nature.com
June 2, 2025 at 10:24 AM
Online now!✨RESEARCH: Gkioni et al @mpiage.bsky.social show that trametinib and rapamycin treatment combine additively to extend lifespan and healthspan in female and male mice, reducing tumor growth and inflammation www.nature.com/articles/s43... rdcu.be/eo3gS
Reposted by Joris Deelen
We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).
June 1, 2025 at 3:26 PM
We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).
Reposted by Joris Deelen
Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...
www.legacy.com/us/obituarie...
THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe
View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.
www.legacy.com
May 30, 2025 at 1:09 PM
Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...
www.legacy.com/us/obituarie...
Reposted by Joris Deelen
New publication from the Deelen Lab—don't miss out! 👇
I am very proud to present you the first paper from the main research line of my group at the @mpiage.bsky.social in collaboration with my current group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC, which is now published in @geroscience.bsky.social!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants - GeroScience
Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-spe...
link.springer.com
May 30, 2025 at 6:56 AM
New publication from the Deelen Lab—don't miss out! 👇
I am very proud to present you the first paper from the main research line of my group at the @mpiage.bsky.social in collaboration with my current group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC, which is now published in @geroscience.bsky.social!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants - GeroScience
Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-spe...
link.springer.com
May 29, 2025 at 7:50 PM
I am very proud to present you the first paper from the main research line of my group at the @mpiage.bsky.social in collaboration with my current group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC, which is now published in @geroscience.bsky.social!
link.springer.com/article/10.1...
link.springer.com/article/10.1...