Jorge Lázaro
@jorgelazaro.bsky.social
Postdoctoral fellow at The Francis Crick Institute. Turner and Briscoe labs. Interested in developmental biology and its temporal control. PhD at the Ebisuya lab. Boehringer Ingelheim Fonds (BIF) alumni.
Reposted by Jorge Lázaro
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Jorge Lázaro
🎙️En motiu del #DiaMundialDelsAnimals, al #PRBBPodcast #LaMareDeLaCiència parlem amb @jorgelazaro.bsky.social d' @embl.org, que ha creat un petit zoo de cèl·lules mare 🧬 per entendre com es desenvolupen els embrions en diferents espècies… inclosos els humans!
🎧Escolta’l aquí 👉https://tuit.cat/y31xe
🎧Escolta’l aquí 👉https://tuit.cat/y31xe
October 3, 2025 at 7:03 PM
🎙️En motiu del #DiaMundialDelsAnimals, al #PRBBPodcast #LaMareDeLaCiència parlem amb @jorgelazaro.bsky.social d' @embl.org, que ha creat un petit zoo de cèl·lules mare 🧬 per entendre com es desenvolupen els embrions en diferents espècies… inclosos els humans!
🎧Escolta’l aquí 👉https://tuit.cat/y31xe
🎧Escolta’l aquí 👉https://tuit.cat/y31xe
Reposted by Jorge Lázaro
Finally .. incredible much awaited wok on deriving avian naive ESCs
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
Derivation of embryonic stem cells across avian species - Nature Biotechnology
Embryonic stem cells for chicken and seven other avian species are derived.
www.nature.com
October 3, 2025 at 2:18 AM
Finally .. incredible much awaited wok on deriving avian naive ESCs
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
“Derivation of embryonic stem cells across avian species”
www.nature.com/articles/s41...
Reposted by Jorge Lázaro
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
September 9, 2025 at 4:05 PM
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
I'm happy to share that I recently started a postdoctoral position in the labs of @lab-turner.bsky.social and @jamesbriscoe.bsky.social at the Francis Crick Institute. Stay tuned for some marsupial development!
May 21, 2025 at 4:03 PM
I'm happy to share that I recently started a postdoctoral position in the labs of @lab-turner.bsky.social and @jamesbriscoe.bsky.social at the Francis Crick Institute. Stay tuned for some marsupial development!
Reposted by Jorge Lázaro
In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling
Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....
Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....
April 23, 2025 at 8:51 AM
In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling
Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....
Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....
Reposted by Jorge Lázaro
Jorge and I wrote an introductory article highlighting two HOT new preprints on the segmentation clock!
In this "In preprints" piece, we highlight recent work from the @sonnenlab.bsky.social and Kageyama labs exploring novel mechanisms and tools involved in cell- and tissue-level couplings during somitogenesis. Congrats to the authors! @dev-journal.bsky.social
doi.org/10.1242/dev....
doi.org/10.1242/dev....
In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling
The segmented body plan of vertebrates becomes apparent during development, when two bilaterally symmetrical rows of somites emerge along the body axis. This process, known as somitogenesis, occurs se...
doi.org
April 17, 2025 at 1:47 PM
Jorge and I wrote an introductory article highlighting two HOT new preprints on the segmentation clock!
In this "In preprints" piece, we highlight recent work from the @sonnenlab.bsky.social and Kageyama labs exploring novel mechanisms and tools involved in cell- and tissue-level couplings during somitogenesis. Congrats to the authors! @dev-journal.bsky.social
doi.org/10.1242/dev....
doi.org/10.1242/dev....
In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling
The segmented body plan of vertebrates becomes apparent during development, when two bilaterally symmetrical rows of somites emerge along the body axis. This process, known as somitogenesis, occurs se...
doi.org
April 17, 2025 at 11:28 AM
In this "In preprints" piece, we highlight recent work from the @sonnenlab.bsky.social and Kageyama labs exploring novel mechanisms and tools involved in cell- and tissue-level couplings during somitogenesis. Congrats to the authors! @dev-journal.bsky.social
doi.org/10.1242/dev....
doi.org/10.1242/dev....
Reposted by Jorge Lázaro
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
March 20, 2025 at 12:13 PM
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Great opportunity and amazing mentor. Do not think twice!
We’re looking for PhD students to join the lab! 🧫🧑🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
PhD Program
Empowering Curious Researchers at the Vienna BioCenter PhD Program
Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter P...
training.vbc.ac.at
April 1, 2025 at 1:30 PM
Great opportunity and amazing mentor. Do not think twice!
Reposted by Jorge Lázaro
We’re looking for PhD students to join the lab! 🧫🧑🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
PhD Program
Empowering Curious Researchers at the Vienna BioCenter PhD Program
Are you a curious and motivated student looking to launch a successful scientific career? Look no further than the Vienna BioCenter P...
training.vbc.ac.at
April 1, 2025 at 1:00 PM
We’re looking for PhD students to join the lab! 🧫🧑🔬
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! training.vbc.ac.at/phd-program/
‼️Deadline: April 15‼️
Reposted by Jorge Lázaro
Latest work:
Review on the evolvability of vertebral number, and the developmental processes underpinning it
Written by Callum Bucklow, @bertaverd.bsky.social, and myself
Check it out here: doi.org/10.32942/X2K...
Review on the evolvability of vertebral number, and the developmental processes underpinning it
Written by Callum Bucklow, @bertaverd.bsky.social, and myself
Check it out here: doi.org/10.32942/X2K...
March 24, 2025 at 9:26 PM
Latest work:
Review on the evolvability of vertebral number, and the developmental processes underpinning it
Written by Callum Bucklow, @bertaverd.bsky.social, and myself
Check it out here: doi.org/10.32942/X2K...
Review on the evolvability of vertebral number, and the developmental processes underpinning it
Written by Callum Bucklow, @bertaverd.bsky.social, and myself
Check it out here: doi.org/10.32942/X2K...
Reposted by Jorge Lázaro
Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!
March 5, 2025 at 10:30 AM
Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!
Incredible news! Congrats Kristina!
Amidst these troubling times, I have some positive personal news to share: I will be joining @imbavienna.bsky.social as a new group leader this fall! 🎉 I am excited for fun projects, surprising discoveries, and great discussions within the fantastic science community @vbcscitraining.bsky.social
Kristina Stapornwongkul is joining IMBA! The Stapornwongkul lab will study how the nutritional environment and metabolic processes influence embryonic development—an emerging research area with broad implications for both fundamental biology and biomedical applications. Welcome, Kristina!
March 5, 2025 at 11:45 AM
Incredible news! Congrats Kristina!
Very happy to see this out. We observed that different metabolic pathways act as selective modulators of developmental tempo instead of affecting it globally. Congrats to Mitsuhiro for all the hard work!
Latest from the lab!
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
Metabolic activities are selective modulators for individual segmentation clock processes - Nature Communications
Metabolism has been considered an attractive candidate as a global modulator of the tempo of multiple developmental processes, including somite segmentation timing. Here they demonstrate that metaboli...
www.nature.com
January 24, 2025 at 6:57 PM
Very happy to see this out. We observed that different metabolic pathways act as selective modulators of developmental tempo instead of affecting it globally. Congrats to Mitsuhiro for all the hard work!
Reposted by Jorge Lázaro
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
www.science.org
January 24, 2025 at 11:02 AM
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
Reposted by Jorge Lázaro
We wrote this for the #SpemannMangold organiser centennial meeting #Freiburg 🙏 It is about whether early embryos should be on top 👆or at the bottom👇of the #hourglass🤔(and other issues)🤓 #InHoxWeTrust 🤟https://pegasus.epfl.ch/?03a82edc91bc5cc1#EKvX77Spd79oMYaisF5hwHBkts6XcGcVnRRDhd5pHNrJ
November 25, 2024 at 10:19 AM
We wrote this for the #SpemannMangold organiser centennial meeting #Freiburg 🙏 It is about whether early embryos should be on top 👆or at the bottom👇of the #hourglass🤔(and other issues)🤓 #InHoxWeTrust 🤟https://pegasus.epfl.ch/?03a82edc91bc5cc1#EKvX77Spd79oMYaisF5hwHBkts6XcGcVnRRDhd5pHNrJ
Thorough study comparing the vertebral formula of more than 388 tetrapod species. The relationship between Hox expression and vertebral identity is not trivial, specially in birds. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 21, 2024 at 8:11 AM
Thorough study comparing the vertebral formula of more than 388 tetrapod species. The relationship between Hox expression and vertebral identity is not trivial, specially in birds. www.pnas.org/doi/10.1073/...
Reposted by Jorge Lázaro
Reposted by Jorge Lázaro
My first post on @bsky.app. So happy to announce that our work has been published in Development by @biologists.bsky.social
doi.org/10.1242/dev....
Also a big thanks for "The people behind the papers" article as well! doi.org/10.1242/dev....
doi.org/10.1242/dev....
Also a big thanks for "The people behind the papers" article as well! doi.org/10.1242/dev....
November 19, 2024 at 6:09 PM
My first post on @bsky.app. So happy to announce that our work has been published in Development by @biologists.bsky.social
doi.org/10.1242/dev....
Also a big thanks for "The people behind the papers" article as well! doi.org/10.1242/dev....
doi.org/10.1242/dev....
Also a big thanks for "The people behind the papers" article as well! doi.org/10.1242/dev....
Reposted by Jorge Lázaro
2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris.
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
November 14, 2024 at 8:32 PM
2nd edition of the EMBO Workshop on Dev timing & evolution will take place in Paris.
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
6-9 May 2025. Save the date!!!
coming-soon.embo.org/w25-105
Thanks to the Ebisuya lab for such a wonderful PhD defense celebration!
November 15, 2024 at 3:43 PM
Thanks to the Ebisuya lab for such a wonderful PhD defense celebration!