Jorge Lázaro
@jorgelazaro.bsky.social
Postdoctoral fellow at The Francis Crick Institute. Turner and Briscoe labs. Interested in developmental biology and its temporal control. PhD at the Ebisuya lab. Boehringer Ingelheim Fonds (BIF) alumni.
Thank you for this extensive review! I really enjoyed reading it.
March 25, 2025 at 9:29 AM
Thank you for this extensive review! I really enjoyed reading it.
The difference in the number of caudal vertebrae (tail length) is most likely controlled by the time it takes until trunk extension stops. This has been nicely addressed here: www.pnas.org/doi/10.1073/...
CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length | PNAS
Mammalian tail length is controlled by several genetic determinants, among which are
Hox13 genes, whose function is to terminate the body axis. Acc...
www.pnas.org
November 21, 2024 at 8:21 AM
The difference in the number of caudal vertebrae (tail length) is most likely controlled by the time it takes until trunk extension stops. This has been nicely addressed here: www.pnas.org/doi/10.1073/...
I like to think that the conserved number of pre-caudal vertebrae in mammals is connected to the scaling between the segmentation clock period and the overall developmental tempo. Allochronic scaling produces similar number of segments.
November 21, 2024 at 8:16 AM
I like to think that the conserved number of pre-caudal vertebrae in mammals is connected to the scaling between the segmentation clock period and the overall developmental tempo. Allochronic scaling produces similar number of segments.