Jonathan G. Stine, MD MSc, FACP
@jonathanstinemd.bsky.social
Global Clinical Program Lead – Late CVRM @AstraZeneca | Clinical Professor of Medicine @PennState | #MASH researcher | Tackling liver health through science & lifestyle | #LiverSky #MASLD #run #lift #yoga #snowboard #read #garden | views my own
Reposted by Jonathan G. Stine, MD MSc, FACP
🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation.
A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.
Rest in peace, Jaime
A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.
Rest in peace, Jaime
July 16, 2025 at 7:11 AM
🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation.
A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.
Rest in peace, Jaime
A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.
Rest in peace, Jaime
The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD.
Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.
Its time to standardize definitions and intervene early:
link.springer.com/article/10.1...
Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.
Its time to standardize definitions and intervene early:
link.springer.com/article/10.1...
June 1, 2025 at 8:57 PM
The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD.
Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.
Its time to standardize definitions and intervene early:
link.springer.com/article/10.1...
Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.
Its time to standardize definitions and intervene early:
link.springer.com/article/10.1...
Reposted by Jonathan G. Stine, MD MSc, FACP
📢Great to write this review for Hep Comms with Matt Armstrong & @jonathanstinemd.bsky.social
💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise
🔗 shorturl.at/aFO1Q
#LiverSky
💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise
🔗 shorturl.at/aFO1Q
#LiverSky
May 25, 2025 at 12:02 PM
📢Great to write this review for Hep Comms with Matt Armstrong & @jonathanstinemd.bsky.social
💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise
🔗 shorturl.at/aFO1Q
#LiverSky
💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise
🔗 shorturl.at/aFO1Q
#LiverSky
It was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle!
If you're looking for holiday weekend reading, look no further:
journals.lww.com/hepcomm/page...
@ebtapper.bsky.social
If you're looking for holiday weekend reading, look no further:
journals.lww.com/hepcomm/page...
@ebtapper.bsky.social
Skeletal muscle and MASLD: Mechanistic and clinical insights : Hepatology Communications
, which all converge on the liver to drive disease progression and adverse patient outcomes. This review explores the mechanistic links between skeletal muscle and MASLD, including the role of abnorma...
journals.lww.com
May 23, 2025 at 8:42 PM
It was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle!
If you're looking for holiday weekend reading, look no further:
journals.lww.com/hepcomm/page...
@ebtapper.bsky.social
If you're looking for holiday weekend reading, look no further:
journals.lww.com/hepcomm/page...
@ebtapper.bsky.social
Reposted by Jonathan G. Stine, MD MSc, FACP
Choose to walk 🚶♂️ or cycle 🚲 whenever possible.
It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.
Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive
It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.
Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive
May 16, 2025 at 10:01 AM
Choose to walk 🚶♂️ or cycle 🚲 whenever possible.
It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.
Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive
It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.
Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive
New review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke
Read here: sciencedirect.com/science/arti...
Read here: sciencedirect.com/science/arti...
Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease
Autophagy, a highly conserved cellular degradation pathway promotes cell survival via lysosomal degradation of aberrant cellular proteins and recyclin…
sciencedirect.com
May 12, 2025 at 9:45 PM
New review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke
Read here: sciencedirect.com/science/arti...
Read here: sciencedirect.com/science/arti...
Heading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth
May 12, 2025 at 9:27 PM
Heading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth
#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃♀️🧬
New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence
pubmed.ncbi.nlm.nih.gov/40206477/
New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence
pubmed.ncbi.nlm.nih.gov/40206477/
April 16, 2025 at 12:32 PM
#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃♀️🧬
New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence
pubmed.ncbi.nlm.nih.gov/40206477/
New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence
pubmed.ncbi.nlm.nih.gov/40206477/
Reposted by Jonathan G. Stine, MD MSc, FACP
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
April 14, 2025 at 1:48 PM
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...
Ok, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂
April 14, 2025 at 4:17 PM
Ok, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂
Reposted by Jonathan G. Stine, MD MSc, FACP
🚨Steatotic liver disease driven by senescent hepatocytes
🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage
www.nature.com/articles/s41...
🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage
www.nature.com/articles/s41...
Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction - Nature Communications
MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively e...
www.nature.com
April 7, 2025 at 6:34 PM
🚨Steatotic liver disease driven by senescent hepatocytes
🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage
www.nature.com/articles/s41...
🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage
www.nature.com/articles/s41...
Reposted by Jonathan G. Stine, MD MSc, FACP
I join >1900 members of US National Academies of Science, Engineering, and Medicine signing this letter, as individuals, decrying the present thoughtless assault on science, which is against our national interests. docs.google.com/document/d/1... Our health, wealth, and security depend on science.
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
docs.google.com
March 31, 2025 at 9:47 PM
I join >1900 members of US National Academies of Science, Engineering, and Medicine signing this letter, as individuals, decrying the present thoughtless assault on science, which is against our national interests. docs.google.com/document/d/1... Our health, wealth, and security depend on science.
Reposted by Jonathan G. Stine, MD MSc, FACP
How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
HHS starts layoffs of thousands of workers across its agencies
Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.
www.statnews.com
April 1, 2025 at 2:44 PM
How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...
🔥🆙 to publish alongside my pre-doc #HannahMohrMS in
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study
Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study
Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...
Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)!
Click on the article title to read more.
onlinelibrary.wiley.com
March 28, 2025 at 3:05 PM
🔥🆙 to publish alongside my pre-doc #HannahMohrMS in
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study
Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study
Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Jonathan G. Stine, MD MSc, FACP
THIS: The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
www.amfar.org/news/how-nih...
www.amfar.org/news/how-nih...
The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
Continued investment in the NIH is essential to fighting current and emerging health threats and to ensuring the U.S. remains a global leader in medical innovation.
www.amfar.org
March 18, 2025 at 3:15 AM
THIS: The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
www.amfar.org/news/how-nih...
www.amfar.org/news/how-nih...
Reposted by Jonathan G. Stine, MD MSc, FACP
Reposted by Jonathan G. Stine, MD MSc, FACP
New paper from us in @jhepatology.bsky.social: www.journal-of-hepatology.eu/article/S016...
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!
Cause-specific mortality in 13,099 patients with metabolic dysfunction-associated steatotic liver disease in Sweden
Data on cause-specific mortality in metabolic dysfunction-associated steatotic liver
disease (MASLD) are limited. We aimed to determine the rate and risk of death from
different causes in patients wit...
www.journal-of-hepatology.eu
March 24, 2025 at 7:51 PM
New paper from us in @jhepatology.bsky.social: www.journal-of-hepatology.eu/article/S016...
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!
Reposted by Jonathan G. Stine, MD MSc, FACP
Our March member spotlight is Dr. Pooja Singhal! She discusses the critical role women #GI docs play in assisting the unique needs of female patients, her involvement in the @amergastroassn.bsky.social Women in GI Workshop & more: buff.ly/dFGqZ2d
March 18, 2025 at 12:00 PM
Our March member spotlight is Dr. Pooja Singhal! She discusses the critical role women #GI docs play in assisting the unique needs of female patients, her involvement in the @amergastroassn.bsky.social Women in GI Workshop & more: buff.ly/dFGqZ2d
Reposted by Jonathan G. Stine, MD MSc, FACP
In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.
March 6, 2025 at 9:34 PM
In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.
Join us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways!
Register here: ce.med.psu.edu/mash/
It’s free!
Register here: ce.med.psu.edu/mash/
It’s free!
Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day - Penn State College of Medicine Continuing Education
Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day is a continuing education program of Penn State College of Medicine taking place in Hershey, Pa.
ce.med.psu.edu
March 18, 2025 at 2:28 PM
Join us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways!
Register here: ce.med.psu.edu/mash/
It’s free!
Register here: ce.med.psu.edu/mash/
It’s free!
Reposted by Jonathan G. Stine, MD MSc, FACP
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Jonathan G. Stine, MD MSc, FACP
Pretty big turnout at Stand Up for Science, talked with scientists and non-scientists who came to DC from all over.
March 7, 2025 at 8:31 PM
Pretty big turnout at Stand Up for Science, talked with scientists and non-scientists who came to DC from all over.
Today is #WorldObesityDay and a good reminder that obesity is a major driver of #MASLD affecting billions worldwide.
The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health.
Let’s turn awareness into action! #ExerciseIsMedicine
The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health.
Let’s turn awareness into action! #ExerciseIsMedicine
March 4, 2025 at 5:59 PM
Today is #WorldObesityDay and a good reminder that obesity is a major driver of #MASLD affecting billions worldwide.
The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health.
Let’s turn awareness into action! #ExerciseIsMedicine
The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health.
Let’s turn awareness into action! #ExerciseIsMedicine